PRAM-1 Is a Novel Adaptor Protein Regulated by Retinoic Acid (RA) and Promyelocytic Leukemia (PML)-RA Receptor α in Acute Promyelocytic Leukemia Cells

Moog-Lutz, Christel; Peterson, Erik; Lutz, Pierre G.; Eliason, Steve; Cavé-Riant, Florence; Singer, Andrew L.; Gioia, Yolande Di; Dmowski, Sally A.; Kamens, Joanne; Cayre, Yvon E.; Koretzky, Gary A.

doi:10.1074/jbc.m011683200

Cited by 52 publications

(51 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Expressed only in monocytes is PRAM1, an adaptor protein that appears to be involved in the differentation of monocytes. 44 The second and most common pattern is transient expression in monocytes differentiated after 1 day, and lost after 7 days. Chemokines CCL24, CXCL1 and CXCL3, and chemokine receptor CCRL2, 45 are expressed in the same pattern.…”

Section: Nk Cellsmentioning

confidence: 99%

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

Abbas¹,

Baldwin²,

Ma³

et al. 2005

Genes Immun

360

356

View full text Add to dashboard Cite

Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. We have compiled a compendium of microarray expression data for virtually all human genes from six key immune cell types and their activated and differentiated states. Immune Response In Silico (IRIS) is a collection of genes that have been selected for specific expression in immune cells. The expression pattern of IRIS genes recapitulates the phylogeny of immune cells in terms of the lineages of their differentiation. Gene Ontology assignments for IRIS genes reveal significant involvement in inflammation and immunity. Genes encoding CD antigens, cytokines, integrins and many other gene families playing key roles in the immune response are highly represented. IRIS also includes proteins of unknown function and expressed sequence tags that may not represent genes. The predicted cellular localization of IRIS proteins is evenly distributed between cell surface and intracellular compartments, indicating that immune specificity is important at many points in the signaling pathways of the immune response. IRIS provides a resource for further investigation into the function of the immune system and immune diseases.

show abstract

Section: Nk Cellsmentioning

confidence: 99%

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

Abbas¹,

Baldwin²,

Ma³

et al. 2005

Genes Immun

360

356

View full text Add to dashboard Cite

show abstract

“…U937-PR9 and U937-MT cells were generously provided by P. G. Pelicci (20). Cells were grown and used as described (21,22). PLB-985/MT-ASB-2 and PLB-985/MT cell lines were used for induction of ASB-2 expression or as control respectively.…”

Section: Methodsmentioning

confidence: 99%

ASB-2 Inhibits Growth and Promotes Commitment in Myeloid Leukemia Cells

Guibal¹,

Moog-Lutz²,

Smolewski³

et al. 2002

Journal of Biological Chemistry

Self Cite

View full text Add to dashboard Cite

“…1) with the T cell adaptor protein, ADAP (∼50%), and also with promyelocytic leukemiaretinoic acid receptor a-regulated adaptor molecule-1 (∼40%) that is mainly expressed in myeloid cells (38,39). Following TCR stimulation, ADAP is well known to mediate specific signaling pathways for inside-out activation of the integrin molecule LFA-1 (24,25).…”

Section: Discussionmentioning

confidence: 99%

ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion

Jung

Yoo

et al. 2016

The Journal of Immunology

View full text Add to dashboard Cite

A novel adaptor protein was identified by analyzing phosphotyrosine proteomes from membrane rafts of activated T cells. This protein showed sequence similarity to a well-known T cell adaptor protein, adhesion and degranulation-promoting adaptor protein (ADAP); therefore, the novel protein was designated activation-dependent, raft-recruited ADAP-like phosphoprotein (ARAP). Suppression of ARAP impaired the major signaling pathways downstream of the TCR. ARAP associated with the Src homology 2 domain of Src homology 2–containing leukocyte protein of 76 kDa via the phosphorylation of two YDDV motifs in response to TCR stimulation. ARAP also mediated integrin activation but was not involved in actin polymerization. The results of this study indicate that a novel T cell adaptor protein, ARAP, plays a unique role in T cells as a part of both the proximal activation signaling and inside–out signaling pathways that result in integrin activation and T cell adhesion.

show abstract

PRAM-1 Is a Novel Adaptor Protein Regulated by Retinoic Acid (RA) and Promyelocytic Leukemia (PML)-RA Receptor α in Acute Promyelocytic Leukemia Cells

Cited by 52 publications

References 48 publications

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

ASB-2 Inhibits Growth and Promotes Commitment in Myeloid Leukemia Cells

ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion

Contact Info

Product

Resources

About