Practical induction heating coil designs for clinical hyperthermia with ferromagnetic implants

Stauffer, Paul R.; Sneed, Penny K.; Hashemi, H.; Phillips, T.L.

doi:10.1109/10.277267

Cited by 60 publications

(45 citation statements)

References 34 publications

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“…These have been summarized in a recent review 25 and include the initial temperature of the colloidal suspension and the sample holder itself (e.g., shape and thermal properties). 26 Besides these parameters, another rarely addressed source of disparity is the stimulus itself: AMFs are usually only homogeneous over small spatial regions, 42,43 implying that such measurements are position-dependent, and therefore can be setup-and/or operator-specific.…”

Section: 39mentioning

confidence: 99%

Lock-In Thermography as an Analytical Tool for Magnetic Nanoparticles: Measuring Heating Power and Magnetic Fields

et al. 2017

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Magnetic nanoparticles and their ability to convert electromagnetic energy into heat are of explicit interest for various applications. However, precise quantification of their heating efficiency is not always upfront, and several parameters render comparative studies challenging. This paper describes the theory behind lock-in thermography, a new technique for quantifying the heating properties of magnetic nanoparticles. This technique allows the investigation of some of the potential sources of variability: key factors such as magnetic field inhomogeneity and its effects on the heating power are explored in detail. The presented results, obtained from various nanoparticle batches of different origins, highlight the importance of pursuing a standardized and systematic approach when quantifying the heating efficiency of magnetic nanoparticles.

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Section: 39mentioning

confidence: 99%

Lock-In Thermography as an Analytical Tool for Magnetic Nanoparticles: Measuring Heating Power and Magnetic Fields

et al. 2017

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“…An often overlooked fact related to solenoids is the presence of an almost homogeneous electric field oriented parallel to the magnetic field [Ellinger et al, 1989] unless adequate electric shielding is used [Stauffer et al, 1994]. An approximate estimate of this field may be obtained from the voltage across the extremes of the inner of the six layers and its length.…”

Section: Exposure Solenoidmentioning

confidence: 99%

Low electromagnetic field (50 Hz) induces differentiation on primary human oral keratinocytes (HOK)

Manni

Lisi

Rieti

et al. 2004

Bioelectromagnetics

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This work concerns the effect of low frequency electromagnetic fields (ELF) on biochemical properties of human oral keratinocytes (HOK). Cells exposed to a 2 mT, 50 Hz, magnetic field, showed by scanning electron microscopy (SEM) modification in shape and morphology; these modifications were also associated with different actin distribution, revealed by phalloidin fluorescence analysis. Moreover, exposed cells had a smaller clonogenic capacity, and decreased cellular growth. Indirect immunofluorescence with fluorescent antibodies against involucrin and beta-catenin, both differentiation and adhesion markers, revealed an increase in involucrin and beta-catenin expression. The advance in differentiation was confirmed by a decrease of expression of epidermal growth factor (EGF) receptor in exposed cells, supporting the idea that exposure to electromagnetic field carries keratinocytes to higher differentiation level. These observations support the hypothesis that 50 Hz electromagnetic fields may modify cell morphology and interfere in differentiation and cellular adhesion of normal keratinocytes.

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“…As has been reported previously, this field is well tolerated clinically even in large patients, effectively coupling energy into implanted ferromagnetic seeds while minimizing undesired heating of normal tissues (Mack et al, 1993, Stauffer et al, 1994. In practice, the field strength should be determined for the worst case high perfusion scenario while using ferroseed materials that undergo their Curie point transition from magnetic to non-magnetic at the desired treatment temperature , Cetas et al, 1998, Kobayashi et al, 1986.…”

Section: Discussionmentioning

confidence: 89%

Tumor bed brachytherapy for locally advanced laryngeal cancer: a feasibility assessment of combination with ferromagnetic hyperthermia

Stauffer¹,

Vasilchenko²,

Osintsev³

et al. 2016

Biomed. Phys. Eng. Express

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Purpose. To assess the feasibility of adding hyperthermia to an original method of organ-preserving brachytherapy treatment for locally advanced head and neck tumors. Methods and materials. The method involves organ-preserving tumor resection and adjunctive high-dose-rate (HDR) brachytherapy delivered via afterloading catheters. These catheters are embedded in a polymeric implant prepared intraoperatively to fill the resection cavity, allowing precise computer planning of dose distribution in the surrounding at-risk tumor bed tissue. Theoretical and experimental analyzes address the feasibility of heating the tumor bed implant by coupling energy from a 100 kHz magnetic field applied externally into ferromagnetic particles, which are uniformly distributed within the implant. The goal is to combine adjuvant hyperthermia (40 °C-45 °C) to at-risk tissue within 5 mm of the resection cavity for thermal enhancement of radiation and chemotherapy response. Results. A fiveyear relapse free survival rate of 95.8% was obtained for a select group of 48 male patients with T3N0M0 larynx tumors, when combining organ-preserving surgery with HDR brachytherapy from a tumor bed implant. Anticipating the need for additional treatment in patients with more advanced disease, a theoretical analysis demonstrates the ability to heat at-risk tissue up to 10 mm from the surface of an implant filled with magnetically coupled ferromagnetic balls. Using a laboratory induction heating system, it takes just over 2 min to increase the target tissue temperature by 10 °C using a 19% volume fraction of ferromagnetic spheres in a 2 cm diameter silicone implant. Conclusion. The promising clinical results of a 48 patient pilot study demonstrate the feasibility of a new organ sparing treatment for laryngeal cancer. Anticipating the need for additional therapy, theoretical estimations of potential implant heating are confirmed with laboratory experiments, preparing the way for future implementation of a thermobrachytherapy implant approach for organ-sparing treatment of locally advanced laryngeal cancer.

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Practical induction heating coil designs for clinical hyperthermia with ferromagnetic implants

Cited by 60 publications

References 34 publications

Lock-In Thermography as an Analytical Tool for Magnetic Nanoparticles: Measuring Heating Power and Magnetic Fields

Lock-In Thermography as an Analytical Tool for Magnetic Nanoparticles: Measuring Heating Power and Magnetic Fields

Low electromagnetic field (50 Hz) induces differentiation on primary human oral keratinocytes (HOK)

Tumor bed brachytherapy for locally advanced laryngeal cancer: a feasibility assessment of combination with ferromagnetic hyperthermia

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