Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease

Lok, Christianne; Trommel, Nienke E. van; Massuger, Leon; Golfier, François; Seckl, Michael J.; Abreu, Miguel; Attia, Jocelyne; Balanchandran, Kirsty; Bergamini, Alice; Bolze, Pierre Adrien; Boog, Lotte; Bowman, Leigh; Casado, Antonio; Chien, Patrick; Cioffi, Raffaella; Coulter, J. B. S.; Delcominette, Sarah; Elmalik, Hind Hamad; Eysbouts, Y.K.; Finci, Vildana; Frijstein, Minke; Fülöp, Vilmos; Goffin, Frédéric; Gomes, Francisco Carrasquinho; Grazia, Cantù Maria; Grischke, Eva‐Maria; Han, Sileny; Harma, Mehmet; Harma, Müge; Harma, Su; Hills, Anne; Ireson, Jane; Joneborg, Ulrika; Kadija, Saša; Kærn, J.; Kenneally, C.; Kesić, Vesna; Korach, Jacob; Korbeľ, M; Lotz, Jean Pierre; Mangili, G.; Marquina, Gloria; Massardier, Jérôme; Mayer, Amit; Meyer-Hamme, Ulrike; Miedzińska, Magdalena; Niemann, Isa; Ottevanger, Nelleke; Özalp, Sinan; Patrier, Sophie; Roes, Eva Maria; Rosseel, Ginette; Salerno, Angela; Sarwar, Naveed; Siegenthaler, Franziska; Singh, Kamaljit; Skupin, Luisa; Solheim, Olesya; Sunde, Lone; Szewczyk, Grzegorz; Tidy, John; Tsip, N; Turowski, G; Undurraga, Manuela; Utracka, Erika; Wallin, Emelie; Westermann, Anneke M.; Winter, M.C.; You, Benoît

doi:10.1016/j.ejca.2020.02.011

Cited by 67 publications

(97 citation statements)

References 27 publications

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“…Treatment of hydatidiform mole consists of uterine evacuation by suction and curettage. US control isrecommended to ensure a thorough evacuation and to minimize the risk of uterine perforation (48). When gestational age is higher than 16 weeks and the uterus is particularly enlarged, the procedure carries a significant risk of bleeding and embolization of molar tissue to the lungs but the treatment must always be done (3).…”

Section: Hydatidiform Molementioning

confidence: 99%

“…When gestational age is higher than 16 weeks and the uterus is particularly enlarged, the procedure carries a significant risk of bleeding and embolization of molar tissue to the lungs but the treatment must always be done (3). Ergometrine or other sustained uterotonic must be started at the onset of suction curettage and continued postoperatively to enhance uterine contractility (48). In women with no childbearing desire, hysterectomy is a valid alternative to uterine curettage, but it requires careful hCG surveillance because these women could still develop GTN (49).…”

Section: Hydatidiform Molementioning

confidence: 99%

“…Subsequently, a single confirmatory hCG measurement is recommended for a PHM over 1 month, and monthly measurements are recommended for a CHM for 6 months. Oral contraceptives may be useful in this timeframe to avoid interferences with hCG measurements due to a new pregnancy or elevated levels of luteinizing hormone (LH) (48). Figure 1 reports the diagnostic pathway for HM.…”

Section: Hydatidiform Molementioning

confidence: 99%

“…GTN should be staged by transvaginal US, chest X-ray and body CT scan (48). These exams allow the definition of FIGO 2000 staging and scoring system (see tables II and III).…”

Section: Stagingmentioning

confidence: 99%

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Gestational trophoblastic disease: an update on pathology, diagnosis and stateof- the-art management

et al. 2021

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Gestational trophoblastic disease (GTD) is a spectrum of disorders originating from the placenta, including premalignant forms, such as complete and partial hydatidiform mole, and the malignant invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. The incidence of GTD varies between countries and the prevalence depends on maternal age, previous GTD history, socioeconomic factors. Histology and molecular genetic studies can help in the diagnostic pathway. Diagnosis of GTD is based on a multifactorial approach consisting of clinical features, serial human chorionic gonadotropin titers, and imaging findings. GTD can result in significant morbidity and mortality if left untreated; early diagnosis of GTD is essential for prompt and successful management while preserving fertility. SOMMARIOLa malattia trofoblastica gestazionale (GTD) rappresenta uno spettro di patologie derivanti dalla placenta, che include forme premaligne, come mola idatidiforme completa e parziale, e forme maligne quali mola invasiva, coriocarcinoma, tumore trofoblastico del sito placentare e tumore trofoblastico epitelioide. L'incidenza di GTD varia, la prevalenza dipende dall'età materna, dalla precedente storia di GTD e dai fattori socio-economici. Istologia e genetica molecolare possono aiutare nel percorso diagnostico. La diagnosi di GTD si basa su un approccio multifattoriale costituito dalla clinica, valutazioni di gonadotropina corionica umana e di diagnostica per immagini. GTD se non trattata può provocare morbilità e mortalità significative; la diagnosi precoce di GTD è essenziale per una gestione ottimale che preservi la fertilità.

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Section: Hydatidiform Molementioning

confidence: 99%

Section: Hydatidiform Molementioning

confidence: 99%

Section: Hydatidiform Molementioning

confidence: 99%

“…GTN should be staged by transvaginal US, chest X-ray and body CT scan (48). These exams allow the definition of FIGO 2000 staging and scoring system (see tables II and III).…”

Section: Stagingmentioning

confidence: 99%

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Gestational trophoblastic disease: an update on pathology, diagnosis and stateof- the-art management

et al. 2021

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“…Gestational trophoblastic neoplasia is a rare disease and is difficult to treat. 73 However, by knocking down Malat1 and inhibiting miR-218 in JEG-3 and JAR cells, Shi et al proved that Malat1 might be able to regulate the expression of Fbxw8 protein, an oncogene, and therefore promote cell growth. 54 In addition, certain studies have identified correlations between Malat1 expression and the onset and development of precancerous cervical lesions, 74 and vulvar squamous cell carcinoma.…”

Section: Gestational Trophoblastic Neoplasiamentioning

confidence: 99%