Epithelioid trophoblastic tumor with antecedent molar pregnancy in an <scp>HIV</scp>‐positive patient

Black, Louisa; Bowes, Alexandra; Seckl, Michael J.; Maher, Geoffrey J.; Kaur, Baljeet; Arumainayagam, Joseph; Acharya, Sashi

doi:10.1002/ccr3.7114

Clinical Case Reports

2023

DOI: 10.1002/ccr3.7114

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Epithelioid trophoblastic tumor with antecedent molar pregnancy in an HIV‐positive patient

Louisa Black

Alexandra Bowes

Michael J. Seckl

et al.

Abstract: Epithelioid trophoblastic tumor (ETT) is a rare malignancy arising from neoplastic proliferation of chorionic‐type intermediate trophoblasts. ETT poses significant challenges to clinicians in the diagnosis and treatment and can hence lead to a poor prognosis. We report a unique case of metastatic ETT in a HIV‐positive patient.

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2024

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References 13 publications

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Epithelioid trophoblastic tumor with lung metastasis: A case report and literature review

Li,

Du,

et al. 2024

Medicine

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Rationale: Epithelioid trophoblastic tumor (ETT) is an extremely rare variant of gestational trophoblastic neoplasms (GTNs). The biological behavior and therapeutic schedule of ETT remains to be defined which frequently poses diagnostic and therapeutic challenges. Although ETT is a relatively indolent malignancy tumor, the therapeutic efficacy and survival rate decrease significantly when presented with metastases. The lung is the most common site of ETT metastasis. Patient concerns: A 39-year-old female patient presented with irregular vaginal bleeding and slight distention pain in lower abdomen. Diagnoses: The patient was diagnosed ETT with lung metastasis after surgery and immunohistochemical staining. Interventions: A total abdominal hysterectomy plus bilateral salpingectomy and histopathology were performed. The patient received 3 cycles of etoposide, methotrexate, actinomycin-D/etoposide, cisplatin (EMA/EP) regimen chemotherapy after surgery. Due to the presence of lung metastasis, she received pulmonary lesion resection and another cycle of postoperative chemotherapy. Outcomes: The patients showed a good response to treatment initially. However, the patient did not complete the full initial treatment for family reasons and had signs of recurrence after 2.5 months. The serum β-hCG level gradually elevated and the lung imaging showed that the lesion area gradually expanded. After 15 months of follow-up, the patient declined further treatment due to a lack of presenting symptoms. Lessons: The diagnosis of ETT should be taken into consideration in patients with abnormal vaginal bleeding and low levels of β-hCG. Patients with metastatic disease should be treated with complete surgical resection and intensive combination chemotherapy to maximize the opportunity for cure. Targeted biological agents might be potential therapeutic strategies for chemotherapy-resistant or recurrent patients.

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Epithelioid trophoblastic tumor with lung metastasis: A case report and literature review

Li,

Du,

et al. 2024

Medicine

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Epithelioid trophoblastic tumor with antecedent molar pregnancy in an HIV‐positive patient

Cited by 1 publication

References 13 publications

Epithelioid trophoblastic tumor with lung metastasis: A case report and literature review

Epithelioid trophoblastic tumor with lung metastasis: A case report and literature review

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