Practical Aspects and Applications of Preparative Supercritical Fluid Chromatography

Francotte, Eric

doi:10.1016/b978-0-12-809207-1.00010-0

Cited by 6 publications

(4 citation statements)

References 90 publications

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“…310 The advantages and applications of supercritical fluid chromatography for enantioseparation are described in the following reviews. [311][312][313][314][315][316][317][318][319][320] When merging simulated moving bed with supercritical fluid chromatography technologies it leads to a purification procedure with unique characteristics with advantages of both techniques, named Supercritical fluid simulated moving bed (SFC-SMB). In 1996, Clavier et al 321 described for the first time the fusion between the two chromatography methods.…”

Section: Supercritical Fluid Simulated Moving Bedmentioning

confidence: 99%

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Semi-continuous and continuous processes for enantiomeric separation

2022

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Section: Supercritical Fluid Simulated Moving Bedmentioning

confidence: 99%

“…310 The advantages and applications of supercritical fluid chromatography for enantioseparation are described in the following reviews. 311–320…”

Section: Continuous Chromatographymentioning

confidence: 99%

Semi-continuous and continuous processes for enantiomeric separation

2022

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“…However, the high cost for optimization in the fermentation process is one of the critical issues in the research and development process because the chemicals, materials, and machinery to conduct the fermentation process are costly due to the specificity [15,16]. This high cost ensures that the results obtained from the study are more accurate and increase the success of the experiment.…”

Section: Introductionmentioning

confidence: 99%

“…This high cost ensures that the results obtained from the study are more accurate and increase the success of the experiment. In the fermentation process, a typical modelbased optimization approach, such as optimal control, provides an alternative to find the optimal feed flow rate, which helps reduce the research cost since the optimal control problem is solved numerically [16].…”

Section: Introductionmentioning

confidence: 99%

Optimal Feeding Strategy in Fermentation of Docosahexaenoic Acid Production by Schizochytrium sp.

et al. 2022

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Fed-batch fermentation has the potential to increase the production of docosahexaenoic acid (DHA) in Schizochytrium sp. which can provide additional nutrients. The feeding strategy in fed-batch fermentation is one of the important aspects that could help in improving the DHA yield. An enhanced scatter search (eSS) method and the control vector parametrization (CVP) approach were applied to generate the optimal feeding trajectory numerically. Three objective functions were considered, namely, maximizing the DHA concentration, minimizing the final time, and maximizing the economic function. The shortest time and maximum DHA could be determined simultaneously from the optimal feeding trajectory in maximizing the economic function.

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Supercritical Fluid Chromatography

Yuan¹,

Olesik²,

West³

2019

Encyclopedia of Analytical Chemistry

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Supercritical fluid chromatography (SFC) employs fluids that are raised above their critical pressure ( P c ) and critical temperature ( T c ) as mobile phases. Carbon dioxide is the fluid most commonly used as a mobile phase for SFC. It is capable of solvating nonpolar and moderately polar analytes. Cosolvents and additives are combined to CO 2 to increase the polarity range of analytes. SFC has a wide versatility in terms of retention mechanisms as all stationary phases employed in normal‐phase or reversed‐phase chromatography can be used. The advantages of SFC over liquid chromatography (LC) include higher efficiency separations and faster speed of analysis and method development. The advantage of SFC over gas chromatography (GC) is that SFC can efficiently separate thermally labile and nonvolatile compounds without the need for derivatization. Capillary SFC is commonly used to separate petroleum distillates and by‐products. The most employed packed‐column SFC is mostly used to analyze achiral and chiral pharmaceuticals, natural products, food products, agrochemicals, and other contaminants in food products or in the environment, and more recently for the analysis of biological samples (lipidomics, metabolomics, and pharmacokinetic studies for instance). Preparative packed column supercritical fluid chromatography (pSFC) is principally employed not only for the purification of pharmaceuticals but also for natural products.

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Practical Aspects and Applications of Preparative Supercritical Fluid Chromatography

Cited by 6 publications

References 90 publications

Semi-continuous and continuous processes for enantiomeric separation

Semi-continuous and continuous processes for enantiomeric separation

Optimal Feeding Strategy in Fermentation of Docosahexaenoic Acid Production by Schizochytrium sp.

Supercritical Fluid Chromatography

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