2022
DOI: 10.1039/d1gc03668h
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Abstract: This review covers continuous preferential crystallization, membrane separation, chromatography, and other techniques identifying the environmental impact and highlighting what should be considered in future development.

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Cited by 7 publications
(3 citation statements)
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“…Among the general methods of chiral resolution, crystallization-based enantioseparation, including classical resolution, preferential crystallization, and so on, is the most flexible and productive way that is easy to be applied on an industrial scale . In classical resolution, a racemic compound (∼90% racemates) is usually resolved by a chiral enantiomerical resolving agent to form diastereomeric salts. , However, only conglomerates (5–10% racemates) and some of the low-component eutectic point racemic compounds (to avoid excessive consumption of pure enantiomers) can be separated into enantiopure components by directly adding the seeds of preferential crystallization …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Among the general methods of chiral resolution, crystallization-based enantioseparation, including classical resolution, preferential crystallization, and so on, is the most flexible and productive way that is easy to be applied on an industrial scale . In classical resolution, a racemic compound (∼90% racemates) is usually resolved by a chiral enantiomerical resolving agent to form diastereomeric salts. , However, only conglomerates (5–10% racemates) and some of the low-component eutectic point racemic compounds (to avoid excessive consumption of pure enantiomers) can be separated into enantiopure components by directly adding the seeds of preferential crystallization …”
Section: Introductionmentioning
confidence: 99%
“…7,8 However, only conglomerates (5−10% racemates) and some of the low-component eutectic point racemic compounds (to avoid excessive consumption of pure enantiomers) can be separated into enantiopure components by directly adding the seeds of preferential crystallization. 9 Fortunately, in recent years it has been found that a crystalline supramolecular assembly with two or more molecules, i.e., multicomponent crystals (salts, cocrystals, or solvates), has the potential to accomplish the chiral separation of two racemic compounds simultaneously. 10,11 Assuming that a couple of racemic compounds can interact with each other (Scheme 1), there are three possible distinct solid-phase compositions in heterogeneous equilibria.…”
Section: Introductionmentioning
confidence: 99%
“…Chirality plays a fundamental role in life. There have been signicant efforts made to develop technologies to separate racemic mixtures to create enantiomerically pure samples [1][2][3] and to perform asymmetric synthesis 4 to provide enantiomerically pure product. Biological channels [5][6][7] and articial nanopores 8,9 have been used to create systems that can distinguish between enantiomeric analytes and to prepare ltration systems capable of transporting a single enantiomer with high selectivity.…”
Section: Introductionmentioning
confidence: 99%