Practical Approach to the Diagnosis and Management of People With Fatty Liver Diseases

George, Jacob; Farrell, Geoffrey C.

doi:10.1002/9780470987438.ch15

Cited by 13 publications

(19 citation statements)

References 67 publications

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“…In accord with international experience, most patients with NAFLD have no symptoms specific to liver disease, the full range of histological manifestations of NAFLD has been demonstrated in Chinese patients, from simple steatosis, through NASH to cirrhosis [28,[46][47][48]. As in North America, Australia and Europe, T2DM is the most important predictor of severe histological disease, and of more frequently abnormal liver function tests among patients with NAFLD [6,27,34,47,49].…”

Section: Clinical Settings Of Chinese Patients With Nafldmentioning

confidence: 74%

“…As in North America, Australia and Europe, T2DM is the most important predictor of severe histological disease, and of more frequently abnormal liver function tests among patients with NAFLD [6,27,34,47,49]. However, the histological severity of steatohepatitis and fibrosis are generally mild in most Chinese patients with biopsy-proven NAFLD, and bridging fibrosis or cirrhosis have seldom been found in Chinese liver biopsy samples [13,28,[45][46][47][48][49][50]. This phenomenon might be partly due to the relatively short duration and possibly mild degree of the underlying obesity and related metabolic disorders in Chinese patients with NAFLD at initial liver biopsy.…”

Section: Clinical Settings Of Chinese Patients With Nafldmentioning

confidence: 99%

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Epidemiology of non-alcoholic fatty liver disease in China

Fan

Farrell

2009

Journal of Hepatology

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468

371

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Fatty liver (steatosis) is highly prevalent in China and is more often linked to obesity than to alcoholism. Among more affluent regions of China, the community prevalence of non-alcoholic fatty liver disease (NAFLD) is approximately 15%. With the increasing pandemic of obesity, the prevalence of NAFLD has approximately doubled in the past decade. The risk factors resemble those in other ethnic populations, but it is important to note that ethnic-specific definitions of central obesity, obesity and metabolic syndrome are more useful in assessment of Chinese people. The full range of histological manifestations of NAFLD has been demonstrated in Chinese patients, but to date hepatic severity is generally mild. In contrast to chronic hepatitis C, steatosis is less common in patients with chronic hepatitis B; it is associated with metabolic, and not viral factors and does not appear to affect disease severity. Although long-term outcomes of NAFLD in Chinese populations remain unclear, it may be a predictor of metabolic disorders, diabetes and cardiovascular disease. Public health interventions are therefore indicated to halt or reverse the national trend of obesity in China so as to improve liver as well as metabolic health.

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Section: Clinical Settings Of Chinese Patients With Nafldmentioning

confidence: 74%

Section: Clinical Settings Of Chinese Patients With Nafldmentioning

confidence: 99%

Epidemiology of non-alcoholic fatty liver disease in China

Fan

Farrell

2009

Journal of Hepatology

Self Cite

468

371

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“…The natural history of young people with elevated ALT is unknown, but fatty liver is a serious condition that compromises liver function and can ultimately lead to liver failure and cirrhosis (23). Lifestyle interventions such as improving diet and increasing physical activity have been effective in reducing severity of fatty liver in adults (24).…”

Section: Discussionmentioning

confidence: 99%

Associations between overweight and obesity and risk factors for cardiovascular disease and fatty liver in young offenders serving community orders

Denney‐Wilson

Kenny

Hardy

et al. 2007

Vulnerable Children and Youth Studies

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Purpose: The health of young offenders supervised in the community has not been previously studied. This paper describes the prevalence of overweight, obesity and obesity associated cardiovascular and hepatic risk factors in a sample of young offenders supervised in the community in New South Wales, Australia. Results: The prevalence of combined overweight and obesity was 33.7% in boys and 35.3% in girls; both rates were higher than those of a comparable community sample. Cardiovascular risk factor prevalence was extremely high compared with other published studies, with over 90% of boys and almost 80% of girls having low levels of HDL cholesterol, and over 40% of both boys and girls having elevated LDL cholesterol. Risk factors for fatty liver disease were also prevalent with almost 15% of boys, and 30% of girls having raised ALT suggesting hepatic cell injury. Cardiovascular and fatty liver disease risk factors were significantly associated with overweight and obesity among boys, but not girls in this sample. Young people of Aboriginal or Torres Strait Islander decent were at no greater risk than the rest of the population.Conclusions: Young offenders are among the most disadvantaged people in Australian society and are particularly vulnerable to a range of health problems. * C. Full Manuscript, inc. Abstract (without Author identifiers)The high prevalence of risk factors represents a substantial health burden for these young people in early adulthood. Timely intervention is required to address the complex health needs of this under-served population.

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“…BMI was calculated by the Quetlet index: weight in kilograms/height in meters squared (kg/m 2 ) [18] . According to modified criteria from the Asia-Pacific guideline, obesity and overweight were defined as follows: obese, BMI ≥ 25 kg/m 2 ; overweight, BMI 23 to 24.9 kg/m 2 , increased WC was defined as ≥ 90 cm in men and ≥ 80 cm in women, and increased WHR was defined as ≥ 0.90 in men and ≥ 0.85 in women [4,19] .…”

Section: Anthropometric and Body Fat Assessmentmentioning

confidence: 99%

Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis

Sobhonslidsuk

Jongjirasiri²,

Thakkinstian³

et al. 2007

WJG

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A m m a r i n T h a k k i n s t i a n , Clinical Epidermiology unit, Ramathibodi Hospital, Mahidol University, Thailand Naruemon Wisedopas, Abstract AIM: To examine whether visceral fat is associated with non-alcoholic steatohepatitis (NASH), to assess for parameters associated with visceral adiposity and to investigate for factors associated with fibrotic severity in NASH. METHODS:Thirty NASH and 30 control subjects u n d e r w e n t b i o c h e m i c a l t e s t s , a n t h r o p o m e t r i c assessment, bioelectrical impedance, dual energy X-ray absorptiometry and abdominal fat study by CT scan. Liver biopsies were graded according to the Brunt criteria. RESULTS:

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Practical Approach to the Diagnosis and Management of People With Fatty Liver Diseases

Cited by 13 publications

References 67 publications

Epidemiology of non-alcoholic fatty liver disease in China

Epidemiology of non-alcoholic fatty liver disease in China

Associations between overweight and obesity and risk factors for cardiovascular disease and fatty liver in young offenders serving community orders

Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis

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