Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis

Sobhonslidsuk, Abhasnee; Jongjirasiri, Sutipong; Thakkinstian, Ammarin; Wisedopas, Naruemon; Bunnag, Pongamorn; Puavilai, G

doi:10.3748/wjg.v13.i26.3614

Cited by 44 publications

(38 citation statements)

References 26 publications

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“…It is also closely linked to non-alcoholic hepatic steatosis and CV diseases (9)(10)(11)(12). Here, a novel association between truncal obesity and fetuin A concentrations is demonstrated in the HD population, many of whom are prone to be thinner and have lower BMI.…”

Section: Discussionmentioning

confidence: 74%

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Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Chen¹,

Chiu²,

Hsu³

et al. 2009

European Journal of Endocrinology

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Background: Fetuin A, a predictor of cardio-vascular (CV) mortality in dialysis patients has been associated with dyslipidemia in non-diabetic coronary artery disease. Truncal obesity is linked to dyslipidemia and also predicts CV mortality. This study had aimed to investigate the associations among fetuin A, truncal obesity, and dyslipidemia in hemodialysis (HD) patients. Methods: One hundred and nine non-diabetic HD patients were evaluated. Waist circumference, highly sensitive C-reactive protein (hs-CRP), fetuin A, and lipoprotein levels (i.e. total cholesterol (T-CHO), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), non-HDL-C, and triglyceride (TG)) were measured for analysis of correlations. The patients were divided into tertiles by fetuin A concentrations. Results: Data from 63 women and 46 men aged 60G13 years were analyzed. Patients in the highest tertile of fetuin A (0.33-0.51 g/l) had higher serum creatinine, albumin, T-CHO, LDL-C, non-HDL-C, and TG, more truncal obesity and lower hs-CRP than patients in the lowest tertile (all P!0.05). In multi-variable linear regression analysis, fetuin A was independently associated with TG level and total iron binding capacity after adjustments for age, hemoglobin, albumin, calcium, body mass index, and hs-CRP. Patients in the highest fetuin A tertile had 3.2-and 4.4-fold higher incidence of truncal obesity (PZ0.038) and hyper-triglyceridemia (PZ0.015) independent of nutritional status and inflammation. Conclusion: Fetuin A is positively associated with truncal obesity and dyslipidemia, which are independent of malnutrition and inflammation. It may predict visceral adiposity and dyslipidemia, especially TG and TG-rich lipoproteins, in HD patients.

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Section: Discussionmentioning

confidence: 74%

“…It is closely related to non-alcoholic hepatic steatosis, epicardial fat deposition, and insulin resistance (IR), and predicts the occurrence of type 2 diabetes mellitus (DM) in the general population (9)(10)(11)(12). Furthermore, deranged visceral adiposity consequently leads to inflammation, dyslipidemia (13), and higher CV mortality.…”

Section: Introductionmentioning

confidence: 99%

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Chen¹,

Chiu²,

Hsu³

et al. 2009

European Journal of Endocrinology

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“…Advanced obesity was stated as a risk factor for the development of liver fibrosis by Sobhonslidsuk et al [11] , Ong et al [12] and Ratziu et al [13] . Recent studies revealed that the people with normal body weight but high visceral fat ratio (central obesity) could have NAFLD, metabolic syndrome and insulin resistance [2,3] .…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies revealed that the people with normal body weight but high visceral fat ratio (central obesity) could have NAFLD, metabolic syndrome and insulin resistance [2,3] . Sobhonslidsuk et al [11] and Cheung et al [14] stated that abdominal obesity correlated only with liver inflammation and so waist circumference predicts metabolic risk condition with the most significance. Angelico et al [15] and Marchesini et al [16] found a correlation between various degrees of liver steatosis and BMI but we did not detect any relationship between steatosis and BMI ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies claimed that metabolic risk factors and insulin resistance could influence liver histology [52] . Sobhonslidsuk et al [11] represented that insulin resistance and elevated visceral fat are risk factors for the presence of NASH. Gholam et al [18] said that individuals with NASH had a high level of insulin resistance when compared to those with simple fatty liver.…”

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confidence: 99%

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Noninvasive predictors for liver fibrosis in patients with nonalcoholic steatohepatitis

Uslusoy¹

2011

WJH

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AIM:To evaluate certain anthropometric, clinical and laboratory features indicating liver fibrosis in nonalcoholic steatohepatitis and to establish the noninvasive markers for liver fibrosis. METHODS:Eighty-one patients (40 male, 41 female) who were diagnosed with fatty liver by ultrasonographic examination and fulfilled the inclusion criteria participated in the study. Anamnesis, anthropometric, clinical and laboratory features of all cases were recorded and then liver biopsy was performed after obtaining patient consent. Steatosis, necroinflammation and liver fibrosis were examined according to age ≥ 45, gender, body mass index, central obesity, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 1, γ-glutamyltransferase (GGT)/ALT > 1, platelet count, insulin, c-peptide levels and the presence of hypertension, diabetes, hypertriglyceridemia and insulin resistance. RESULTS:Eighty-one patients with non-alcoholic steatohepatitis (NASH) enrolled in the study. 69 of 81 patients were diagnosed with NASH, 11 were diagnosed with simple fatty liver and 1 was diagnosed with cirrhosis. AST/ALT > 1, GGT/ALT > 11, high serum ferritin and fasting insulin levels, the presence of diabetes, hypertension, hypertriglyceridemia and insulin resistance seemed to enhance the severity of steatosis, necroinflammation and fibrosis but these results were not statistically significant. CONCLUSION:Liver steatosis and fibrosis can occur in individuals with normal weight. There was no significant concordance between severity of liver histology and the presence of predictors for liver fibrosis including metabolic risk factors.

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“Bioelectrical impedance analysis in managing sarcopenic obesity in NAFLD”

Hanna

Jamieson

Lee

et al. 2021

Obesity Science & Practice

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Introduction: Sarcopenic obesity and its association with nonalcoholic fatty liver disease (NAFLD) is under-recognized by many healthcare providers in Western medicine due to the lack of awareness and diagnostic guidelines. The result is delayed recognition and treatment, which leads to further health deterioration and increased healthcare costs. Sarcopenic obesity is characterized by the presence of increased fat mass in combination with muscle catabolism related to chronic inflammation and/or inactivity. Previous research has recommended evaluating body composition and physical function performance to adequately diagnose sarcopenic obesity. Body composition analysis can be performed by imaging applications through magnetic resonance imaging, computed tomography, and dual-energy x-ray absorptiometry. Due to the cost of each device and radiation exposure for patients as evidenced in all three modalities, bioelectrical impedance analysis offers a noninvasive approach capable of providing quick and reliable estimates of lean body and fat mass. Methods and Results: This review analyzes the current evidence-based literature, indicating a lower skeletal muscle mass and increased visceral adipose tissue correlation to the advancement of fibrosis in fatty liver disease. Conclusion: Given the substantial promising research conducted in predominantlyAsian populations regarding body tissue distribution and NAFLD, additional prospective research is needed to extend these findings in Western populations.

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Visceral fat and insulin resistance as predictors of non-alcoholic steatohepatitis

Cited by 44 publications

References 26 publications

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients

Noninvasive predictors for liver fibrosis in patients with nonalcoholic steatohepatitis

“Bioelectrical impedance analysis in managing sarcopenic obesity in NAFLD”

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