Pr�fung extrakardialer wirkungen an der digitalisunterempfindlichen ratte

Lendle, L.; Oldenburg, Dirk

doi:10.1007/bf00245315

Cited by 13 publications

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“…The animals were used in four groups: 45 rats received digoxin (Digoxin@, Orion, Finland) 1 mg/kg (Lendle & Oldenburg 1950), subcutaneously in ethanol : glycerol: water (1 : 1 : 1) (Turto & Lindy 1973) 0.5 mg/ml daily for 1-8 days; 30 rats were injected with the solvent 2 ml/kg for 1-8 days; 15 rats were used to determine dry/wet weight ratio of hearts after 1 and 2 digoxin injections; 12 rats were used to measure the effect of 1 mg/kg digoxin on heart rate during four days treatment. The rats were killed by a blow on the head and a piece of each left ventricle was cut out, cooled in isopenthane in liquid nitrogen and stored in isopenthane at -80" until homogenization.…”

Section: Methodsmentioning

confidence: 99%

Enzyme Activities of Myocardial Energy Metabolism during Prolonged Digoxin Treatment in Rats

Pelkonen

1978

Acta Pharmacologica et Toxicologica

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The effect of prolonged digoxin treatment ( I mg/kg day for 8 days) on the activity levels of some enzymes of energy metabolism (phosphofructokinase, lactate dehydrogenase, citrate synthase, succinate dehydrogenase) in rat myocardium was studied. In the control animals receiving the solvent mixture (glycerol : ethano1:water in 1 : 1 : 1) a transient decrease in the lactate dehydrogenase and citrate synthase activity levels was observed. In the hearts ofdigoxin treated rats the level of activity of phosphofructokinase was permanently lowered by the fourth day and the level of activity of citrate synthase permanently increased after the first day of treatment. A transient increase in the activity level of succinate dehydrogenase in the myocardium of digoxin treated animals was seen between days 1 and 6. In this study a permanent decrease in phosphofructokinase and an increase in citrate synthase activity levels in rat heart muscle was noted during prolonged digoxin treatment.

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Section: Methodsmentioning

confidence: 99%