PPh3-catalyzed Mannich reaction: a facile one-pot synthesis of β-amino carbonyl compounds under solvent-free conditions at room temperature

Novel Phenolic 1-aryl-3-arylamino-1-propanones: Synthesis and Characterization

“…In contrast to 1,2-diaryl-3-arylamino-1-propanones, which are conveniently obtained through the direct condensation of a aryl methyl ketone, an aromatic aldehyde and an arylamine in the presence of various catalysts, [16][17][18] β-arylamino ketones lacking any substituent at position 2 of the oxopropylidene linker are usually prepared by replacing the quaternized, easily leaving dialkylamino group in ketonic Mannich base hydrochlorides with an arylamino moiety. 19 Using the latter synthetic approach, two different types of phenolic 1-aryl-3-arylamino-1-propanones can be prepared.…”

Microwave-Assisted Synthesis of Mono- and Disubstituted 4-Hydroxyacetophenone Derivatives via Mannich Reaction: Synthesis, XRD and HS-Analysis

“…The conventional multicomponent Mannich reactions are found to have drawbacks such as a long reaction time, harsh reaction conditions, and toxic vapor and byproducts [15]. As a consequence, different reaction conditions have been widely described for Mannich reaction in the presence of a variety of catalysts [16,17]. Additionally, a continuous search for the synthetic methodologies of cleaner Mannich reactions seeking green chemistry principles includes the use of protocols in water [14], biodegradable and reusable catalysts [18,19], ionic liquids [12,19,20], and solvent-free and/or catalyst-free media reaction conditions under microwave (MW) and ultrasound irradiation [21,22,23,24,25,26,27].…”