Synthesis and substrate-controlled modification of β-aminocarbonyl using α-amylase enzyme and Pd-catalyst in one-pot

Experimental and computational investigation of the α-amylase catalyzed Friedel–Crafts reaction of isatin to access symmetrical and unsymmetrical 3,3′,3′′-trisindoles

“…12 Previously, we have also reported a number of novel enzymatic transformations using lipase and α-amylase as a catalyst. 13,14 Recently, we reported the application of the α-amylase enzyme in the gram-scale synthesis of bis-indole containing bioactive molecules. 15 Keeping in view the diverse applications of 3,3′,3′′-trisindoles and limitations of the previously reported methods, herein, we report the highly selective and efficient synthesis of symmetrical and unsymmetrical 3,3′,3′′-trisindoles using the α-amylase enzyme catalysed Friedel–Crafts type reaction of isatin and indoles.…”