PPARγ2 Pro12Ala Polymorphism and Insulin Resistance in Japanese Hypertensive Patients

Abstract

We investigated the relationship between peroxisome proliferator-activated receptor (PPAR ) Pro12Alasubstitution and insulin resistance in subjects with normal insulin secretory capacity, since it has been reported that PPAR may affect not only insulin resistance but also insulin secretion. We examined 81 Japanese male patients with untreated essential hypertension using the glucose clamp technique. We found 77 subjects with Pro/Pro and 4 subjects with Pro/Ala genotype, and the glucose disposal rate was not signifi-

No Association of Pro12Ala Polymorphism of PPAR-.GAMMA. Gene With Coronary Artery Disease in Korean Subjects

“…26,31,32 Similar results were observed in other studies performed in other Asian populations, with rare frequency of the Ala12Ala genotype. 33,34 In the present study the allele frequency of alanine was 0.043, similar to the previous studies.…”

Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes

“…11 The following pair of primers was used for DNA amplification by PCR: 5 0 -CAAGCCCAGTCCTTTCTGTG-3 0 as a sense primer (PPAR-f) and 5 0 -AGTGAAGGAATC GCTTTCCG-3 0 as an antisense primer (PPAR-r) (GenBank accession AB005520). These primers yielded PCR product of 236 bp in length.…”

Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design

“…12,13,23 However, only a few studies have successfully shown that a mutation is associated with phenotypes that are related to insulin resistance and associated with hypertension. [24][25][26][27] This study indicates that the CA16 microsatellite polymorphism in the TNFR2 gene is a potential marker for severe hypertension associated with insulin resistance.…”