No abstract

Effects of magnesium (Mg) supplementation on nine mild type 2 diabetic patients with stable glycemic control were investigated. Water from a salt lake with a high natural Mg content (7.1%) (MAG21) was used for supplementation after dilution with distilled water to 100mg/100mL; 300mL/day was given for 30 days. Fasting serum immunoreactive insulin level decreased significantly, as did HOMA squareR (both p < 0.05). There was also a marked decrease of the mean triglyceride level after supplementation. The patients with hypertension showed significant reduction of systolic (p < 0.01), diastolic (p = 0.0038), and mean (p < 0.01) blood pressure. The salt lake water supplement, MAG21, exerted clinical benefit as a Mg supplement in patients with mild type 2 diabetes mellitus.

U ntil recently, the importance of aldosterone in the development of hypertension has been underestimated and the assumption made that aldosterone-mediated effects could be adequately controlled with angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs). However, long-term ACE inhibitor or ARB therapy may not adequately protect patients from the effects of aldosterone escape [1][2][3] -an effect that can be minimized by blocking aldosterone at the mineralocorticoid receptor. 4A growing body of clinical evidence has linked aldosterone to the development of hypertension, cardiac hypertrophy, cardiac and vascular fibrosis,