PPARα signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle

Qin, Wenyi; Liang, Chunnian; Guo, Xian; Chen, Min; Pei, Jie; Bao, Pengjia; Wu, Xiaoyun; Li, T K; Yan, Ping

doi:10.4238/2015.november.18.9

Cited by 14 publications

(12 citation statements)

References 24 publications

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“…Previous studies have shown that PLTP was expressed in a wide variety of tissues (e.g., muscle) to mediate a net transfer of phospholipids between vesicles and plasma (Jauhiainen and Ehnholm, 2005). Additionally, PLTP played a role in cholesterol and fatty acid metabolism (Beyer et al, 2004), and was involved in the variations of muscle lipid composition and flavor in beef (Dunner et al, 2013;Qin et al, 2015). Another highly significant gene, CDKN1A, is known to play an important part in cell cycle regulation.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic changes in bovine skeletal muscle cells after resveratrol treatment

Hao

Wang

et al. 2020

Gene

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic changes in bovine skeletal muscle cells after resveratrol treatment

Hao

Wang

et al. 2020

Gene

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“…54 Previous research has found that the expression level of PLTP is positively correlated with SFA (P < 0.05) in muscle and has large effects on the ratio of n-6:n-3. 55 In addition, PCYT1A is the rate-limiting enzyme of phosphatidylcholine synthesis 56 and single nucleotide polymorphisms in this gene are involved in the FA profile in muscle. 57 Therefore, these results suggest that the regulation of phospholipid metabolism is an important factor that affects the IMF deposition in chickens.…”

Section: Discussionmentioning

confidence: 99%

Weighted gene coexpression network analysis identifies specific transcriptional modules and hub genes related to intramuscular fat traits in chicken breast muscle

Zhao

et al. 2019

J of Cellular Biochemistry

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Intramuscular fat (IMF) traits are important factors that influence meat quality. However, the molecular regulatory mechanisms that underlie this trait in chickens are still poorly understood at the gene coexpression level.Here, we performed a weighted gene coexpression network analysis between IMF traits and transcriptome profile in breast muscle in the Chinese domestic Gushi chicken breed at 6, 14, 22, and 30 weeks. A total of 26 coexpressed gene modules were identified. Six modules, which included the dark gray, purple, cyan, pink, light cyan, and blue modules, showed a significant positive correlation (P < 0.05) with IMF traits. The strongest correlation was observed between the dark gray module and IMF content (r = 0.85; P = 4e-04) and between the blue module and different fatty acid content (r = 0.87~0.91; P = 5e-05~2e-04). Enrichment analysis showed that the enrichment of biological processes, such as fatty acid metabolic process, fat cell differentiation, acylglycerol metabolic process, and glycerolipid metabolism were significantly different in the six modules. In addition, the 32, 24, 4, 7, 6, and 25 hub genes were identified from the blue, pink, light cyan, cyan, dark gray, and purple modules, respectively. These hub genes are involved in multiple links to fatty acid metabolism, phospholipid metabolism, cholesterol metabolism, diverse cellular behaviors, and cell events. These results provide novel insights into the molecular regulatory mechanisms for IMF-related traits in chicken and may also help to uncover the formation mechanism for excellent meat quality traits in local breeds of Chinese chicken. K E Y W O R D S chicken, gene module, hub gene, intramuscular fat traits, weighted gene coexpression network analysis

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“…PPARA is a key determinant of metabolic adaptation to increases in fatty acid concentrations (Monsalve et al 2013). The expression of genes in the PPARα signaling pathway is also associated with the fatty acid content in yak and cattle longissimus dorsi muscles (Qin et al 2015). Changes in the fat composition within muscle tissues affect meat quality.…”

Section: Discussionmentioning

confidence: 99%

Chinese yellow cattle PPARA gene: Analyses of expression, polymorphism and trait association

Chen¹,

Zhang²,

ZHI³

et al. 2018

CZECH J ANIM SCI

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Peroxisome proliferator-activated receptor alpha (PPARA) is a member of the nuclear receptor superfamily that regulates key proteins involved in fatty acid oxidation and extracellular lipid metabolism. Given the importance of PPARA in modulating energy metabolism, PPARA may be a suitable candidate gene for assessing economic traits in cattle. In the present study, the genetic diversity of the PPARA gene in Chinese cattle breeds and its effects on growth traits in the Nanyang and Jiaxian breeds were investigated. First, the transcript profiles for PPARA were determined in eight adult cattle tissue types. Next, polymorphisms were identified in the coding and predicted promoter regions of the bovine PPARA gene in 424 animals. Finally, an association study was carried out to evaluate the relationship between PPARA and the development of cattle. Based on quantitative real-time polymerase chain reaction, PPARA was mainly expressed in the kidney and liver. Nine single nucleotide polymorphisms (SNPs) were identified in Chinese domestic cattle, including one novel SNP. Haplotype frequencies and linkage disequilibrium were also investigated. Four SNPs (g.17148558A>T, g.117195348A>G, g.117228160T>C, and g.117233248A>G) showed significant associations with growth traits in NY and JX cattle, including body weight, average daily gain, and hipbone width. These results confirmed the importance of PPARA as a candidate gene for marker-assisted selection for growth traits in cattle.

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PPARα signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle

Cited by 14 publications

References 24 publications

Transcriptomic changes in bovine skeletal muscle cells after resveratrol treatment

Transcriptomic changes in bovine skeletal muscle cells after resveratrol treatment

Weighted gene coexpression network analysis identifies specific transcriptional modules and hub genes related to intramuscular fat traits in chicken breast muscle

Chinese yellow cattle PPARA gene: Analyses of expression, polymorphism and trait association

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