PPARα Is Regulated by miR-21 and miR-27b in Human Liver

Kida, Katsuhiko; Nakajima, Miki; Mohri, Takuya; Oda, Yoshiko; Takagi, Shingo; Fukami, Tatsuki; Yokoi, Tsuyoshi

doi:10.1007/s11095-011-0473-y

Cited by 119 publications

(97 citation statements)

References 32 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following the discovery of developmental and sexual CYP3A4 transgene expression in CYP3A4-transgenic mouse models (Yu et al, 2005), we demonstrated the involvement of miR-27b and murine miR-298 (mmu-miR-298) in regulation of CYP3A4 through targeting of its 39UTR as well as the vitamin D receptor transcription factor (Pan et al, 2009a). Other studies also revealed the importance of miR-27b in regulation of P450 enzyme CYP1B1 (Tsuchiya et al, 2006) and nuclear receptors retinoid X receptor alpha and peroxisome proliferator-activated receptor alpha (Ji et al, 2009;Kida et al, 2011). These findings indicate that miRNAs may modulate drug metabolism through "direct" and "indirect" regulation of drug-metabolizing enzymes.…”

Section: Noncoding Micrornas In the Control Of Drug Metabolism And Trmentioning

confidence: 72%

Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport

et al. 2013

View full text Add to dashboard Cite

This is a report of a symposium on the potential role of epigenetic mechanisms in the control of drug disposition sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 2013 meeting in Boston, MA, April 21, 2013. Epigenetics is a rapidly evolving area, and recent studies have revealed that expression of drug-metabolizing enzymes and transporters is regulated by epigenetic factors, including histone modification, DNA methylation, and noncoding RNAs. The symposium speakers provided an overview of genetic and epigenetic mechanisms underlying variable drug metabolism and drug response, as well as the implications for personalized medicine. Considerable insight into the epigenetic mechanisms in differential regulation of the dioxininducible drug and carcinogen-metabolizing enzymes CYP1A1 and 1B1 was provided. The role of noncoding microRNAs in the control of drug metabolism and disposition through targeting of cytochrome P450 (P450) enzymes and ATP-binding cassette membrane transporters was discussed. In addition, potential effects of xenobiotics on chromatin interactions and epigenomics, as well as the possible role of long noncoding RNAs in regulation of P450s during liver maturation were presented.

show abstract

Section: Noncoding Micrornas In the Control Of Drug Metabolism And Trmentioning

confidence: 72%

Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport

et al. 2013

View full text Add to dashboard Cite

show abstract

“…In addition to direct targeting of CYP3A4 (Pan et al, 2009a), CYP1B1 (Tsuchiya et al, 2006), and ABCB1 (Zhu et al, 2008), miR27b/a was able to act on a number of xenobiotic receptors and transcription factors including NR1I1/ (Pan et al, 2009a), NR1C1/ PPARa (Kida et al, 2011), ERa/NR3A1 (Li et al, 2010a), NFE2L2/ Nrf2 (Narasimhan et al, 2012), and RXRa/NR2B1 (Ji et al, 2009). Therefore, alteration of enzyme/transporter protein outcome by miR27b/a could be an accumulative effect from direct targeting of the enzyme/transporter and "indirect" targeting of regulatory factors including xenobiotic receptors and transcription factors (Yu, 2009;Yu and Pan, 2012).…”

Section: Micrornas In Posttranscriptional Gene Regulationmentioning

confidence: 99%

MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy

Tian

et al. 2015

Drug Metabolism and Disposition

View full text Add to dashboard Cite

Knowledge of drug absorption, distribution, metabolism, and excretion (ADME) or pharmacokinetics properties is essential for drug development and safe use of medicine. Varied or altered ADME may lead to a loss of efficacy or adverse drug effects. Understanding the causes of variations in drug disposition and response has proven critical for the practice of personalized or precision medicine. The rise of noncoding microRNA (miRNA) pharmacoepigenetics and pharmacoepigenomics has come with accumulating evidence supporting the role of miRNAs in the modulation of ADME gene expression and then drug disposition and response. In this article, we review the advances in miRNA pharmacoepigenetics including the mechanistic actions of miRNAs in the modulation of Phase I and II drug-metabolizing enzymes, efflux and uptake transporters, and xenobiotic receptors or transcription factors after briefly introducing the characteristics of miRNA-mediated posttranscriptional gene regulation. Consequently, miRNAs may have significant influence on drug disposition and response. Therefore, research on miRNA pharmacoepigenetics shall not only improve mechanistic understanding of variations in pharmacotherapy but also provide novel insights into developing more effective therapeutic strategies.

show abstract

“…It has been reported that miR-27 enhances differentiation of osteoblasts and strongly inhibits adipogenesis (Lin et al, 2009;Wang and Xu, 2010). MiR-27b is a regulatory hub in lipid metabolism through repressing critical regulators of lipid homeostasis, such as PPARα, HMGCR (Kida et al, 2011, Vickers et al, 2013. In a recent study, miR-27b was reported to specifically target to bovine myostatin (Miretti et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression

Yang

Chen

Huang

et al. 2014

Animal

View full text Add to dashboard Cite

MicroRNAs are endogenous~22nt RNAs that negatively regulate gene expression at the posttranscriptional level via binding to the 3′-untranslated region (3′UTR) of target mRNAs. The microRNA miR-27a was reported to depress the expression of myostatin, a critical inhibitor of skeletal myogenesis, by binding to its 3′UTR in mouse. In this study, we cloned the full-length 3′UTR of porcine myostatin by rapid amplification of 3′-cDNA ends (3′-RACE) and demonstrated that the 3′UTR of porcine myostatin is targeted by miR-27a. The phenomenon that the level of myostatin inversely correlated with miR-27a was observed in fat and heart of pigs and also in proliferating porcine myoblasts. Besides, overexpression of miR-27a in porcine myoblasts promoted cell proliferation by reducing the expression of myostatin. Our data suggest that miR-27a positive regulates porcine myoblast proliferation via targeting myostatin.

show abstract

PPARα Is Regulated by miR-21 and miR-27b in Human Liver

Abstract: We found that PPARα in human liver is regulated by miRNAs.

Cited by 119 publications

References 32 publications

Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport

Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport

MicroRNA Pharmacoepigenetics: Posttranscriptional Regulation Mechanisms behind Variable Drug Disposition and Strategy to Develop More Effective Therapy

MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression

Contact Info

Product

Resources

About