PP095 [Extracorporeal Support » Renal replacement therapies]: CLINICAL CHARACTERISTICS AND OUTCOMES OF CRRT PERFORMED INFANTS AND NEWBORNS WEIGHING UP TO 10 KILOGRAMS

Abstract

BACKGROUND AND AIM:The aim of this study is to determine the clinical course and investigate the factors related to survival in children weighted up to 10 kg treated with continuous renal replacement therapy (CRRT). METHOD:This study is retrospective observational cohort study. We included children up to 10 kg, treated with CRRT between January 2015 and March 2021 in five PICUs. RESULTS:One-hundred-forty-one children treated with CRRT were enrolled during the study period. The children comprised 74 male (52.5%) with a median age of 6 (2-12) months. The median weight of patients was 6 (4-8.35) kg. The median PRISM III score of all patients was 17(IQR 10-27). The fifty-two patient (36.9%) weighted less than 5 kg. Fluid overload (53.2%) was the most common indication for CRRT followed by sepsis with multiorgan failure (44%). The median PICU length of stay was 10 days (IQR 4-25). The overall mortality was 48.2%. Survivors and non survivors showed significant differences age, weight, PRISM III score, pediatric PELOD score, number of multiorgan failure, organ failure (respiratory, heart, hematologic, renal, hepatology), fluid overload, acute kidney injury, sepsis with organ failure, mechanic support therapy including invasive mechanic ventilation, extracorporeal membrane oxygenation. The most common CRRT modality was continuous venovenous hemodiafiltration (55.3%). The survival time showed significant differences hepatic failure, circulation failure (p:0.042, p=0.010, respectively). CONCLUSIONS:Despite the technical difficulties of using modified equipment in critically ill children with a bodyweight of less than 10 kg, CRRT is a safe, sustainable, and beneficial extracorporeal treatment modality.