Pp021-Mon Preoperative Systemic Inflammatory Response Is Associated With Perioperative Central Venous Catheter-Related Bloodstream Infection in Colorectal Cancer Patients Receiving Parental Nutrition

Ishizuka, Mitsuru; Nagata, Hitoshi; Takagi, Korehiko; Iwasaki, Youichi; Kubota, Keiichi

doi:10.1016/s1744-1161(11)70313-1

Cited by 4 publications

(7 citation statements)

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“…We grouped the published studies into three groups (Table 1) [34567891011121314151617181920212223242526272829303132333435363738394041424344454647484950515253545556575859606263646566676869707172737475767778798081]. The first group included studies that identified the characteristics of hosts exhibiting inflammation, the second group included studies that measured the effect of treatment interventions, and the third group included studies that predicted the outcomes of interventions.…”

Section: Factors Associated With Inflammation In Patients With Cancermentioning

confidence: 99%

“…The most classical clinical outcomes measured following therapeutic interventions, such as surgery, chemotherapy, or radiotherapy are complication rates and recovery time in short-term [61], and survival without unfavorable events in long-term [71]. Additionally, some inflammation parameters including tumor-infiltrating lymphocytes or composite scores can be used for predicting the inflammation response following neoadjuvant chemo-radiation therapy [6465] or for anticipating an infection [66] following an intervention.…”

Section: Factors Associated With Inflammation In Patients With Cancermentioning

confidence: 99%

“…Historically, laboratory values are used to assess the inflammatory status of the patients (Table 2) [317232634353839424450596266697173747576777879848687888990919293949596979899100101102103104105106]. Laboratory parameters are economical to evaluate, easily measurable, repeatable, and ready to use in daily clinical practice.…”

Section: Approaches For Evaluating Inflammatory Parametersmentioning

confidence: 99%

“…The combination of CRP and albumin has been extensively studied for the prediction of survival [106111], tumor recurrence [7071], peri-operative mortality [58], and specific outcomes, such as central venous catheter-related bloodstream infection [66]. The predictive value of CRP and albumin combination is not conclusive due to the heterogeneity in results reported by different studies.…”

Section: Approaches For Evaluating Inflammatory Parametersmentioning

confidence: 99%

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Biomarkers for Evaluating the Inflammation Status in Patients with Cancer

Güner

Kim

2019

J Gastric Cancer

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Inflammation can be a causative factor for carcinogenesis or can result from a consequence of cancer progression. Moreover, cancer therapeutic interventions can also induce an inflammatory response. Various inflammatory parameters are used to assess the inflammatory status during cancer treatment. It is important to select the most optimal biomarker among these parameters. Additionally, suitable biomarkers must be examined if there are no known parameters. We briefly reviewed the published literature for the use of inflammatory parameters in the treatment of patients with cancer. Most studies on inflammation evaluated the correlation between host characteristics, effect of interventions, and clinical outcomes. Additionally, the levels of C-reactive protein, albumin, lymphocytes, and platelets were the most commonly used laboratory parameters, either independently or in combination with other laboratory parameters and clinical characteristics. Furthermore, the immune parameters are classically examined using flow cytometry, immunohistochemical staining, and enzymelinked immunosorbent assay techniques. However, gene expression profiling can aid in assessing the overall peri-interventional immune status. The checklists of guidelines, such as STAndards for Reporting of Diagnostic accuracy and REporting recommendations for tumor MARKer prognostic studies should be considered when designing studies to investigate the inflammatory parameters. Finally, the data should be interpreted after adjusting for clinically important variables, such as age and cancer stage.

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Section: Factors Associated With Inflammation In Patients With Cancermentioning

confidence: 99%

Section: Factors Associated With Inflammation In Patients With Cancermentioning

confidence: 99%

Section: Approaches For Evaluating Inflammatory Parametersmentioning

confidence: 99%

Section: Approaches For Evaluating Inflammatory Parametersmentioning

confidence: 99%

See 2 more Smart Citations

Biomarkers for Evaluating the Inflammation Status in Patients with Cancer

Güner

Kim

2019

J Gastric Cancer

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“…In particular, a CRP value of more than 150 mg/L on day 2 and a rising CRP level on day 3 were found to be significant factors. Using the Glasgow Prognostic Score (GPS), based on CRP and albumin, Ishizuka et al 17 found that the systemic inflammatory response predicts perioperative central venous catheter-related bloodstream infection in patients undergoing colorectal surgery who have been administered parenteral nutrition. Furthermore, the metabolic response to surgery may lead to complications.…”

Section: Markers Of Surgical Stressmentioning

confidence: 99%

Surgical Stress Response After Colorectal Resection

Andersson

Ansari

Nordén

et al. 2013

International Surgery

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The human body's response to surgery is correlated with the extent of tissue damage. The aim of the present study was to, over time, map out parameters concerning inflammation, metabolism, nutrition, breathing function, muscle strength, and well-being in elective colorectal surgery. Eighteen patients were prospectively included: colon resection (n ¼ 9) and rectum resection/amputation (n ¼ 9). Postoperative interleukin 10 (IL-10) rose more in the rectum surgery group on day 0 (P ¼ 0.007) and day 3 (P ¼ 0.025). Furthermore, significant differences between groups were detected regarding albumin, prealbumin, and total iron-binding capacity (TIBC). For albumin and TIBC, this difference was seen even on day 7. C-reactive protein, IL-6, IL-8, glucose, cortisol, insulin, pain, fatigue, nausea, grip strength, and forced expiratory volume in 1 second did not show any differences. No correlation was revealed between measured parameters and postoperative complications. Postoperative levels of IL-10, albumin, prealbumin, and TIBC may be used as determinants of surgical stress after colorectal surgery.

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Effects of lipid emulsion on the formation of Escherichia coli –Candida albicans mixed species biofilm on PVC

Duan

Lei

et al. 2021

Preprint

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Patients receiving lipid emulsion have an increased risk of central venous catheter-related bloodstream infections (CRSBI) in the clinic. More than 15% of CRBSI are found to be polymicrobial. The objective of the study was to explore the mechanism and effects of lipid emulsion on the formation of Escherichia coli-Candida albicans mixed species biofilm (BF) on the surface of polyvinylchloride (PVC) materials. Mixed BFs were achieved by co-culturing Escherichia coli (E.coli) and Candida albicans (Ca) with PVC in various concentrations of lipid emulsion respectively. Crystal violet (CV) staining and XTT assay were performed to test the formation of BFs and the viability of bacteria in BFs. The microstructures of BFs were observed by a combined approach of fluorescence in situ hybridization (FISH), confocal laser scanning microscopy (CLSM), and scanning electron microscopy (SEM). The study found that lipid emulsion promoted the formation of Escherichia coli-Candida albicans mixed biofilm, especially 10% lipid emulsion. The mechnism of lipid emulsion prompting mixed biofilm formation may be significantly up-regulating the expression of flhDC, iha, HTA1, and HWP1 genes associated with bacterial motility, adhesion and biofilm formation. For prevention of central venous catheter-associated infections, medical professionals should maintain strict aseptic precautions when handling lipid emulsion and avoid using high concentrations of lipid emulsion for a long time as much as possible. The study provides interesting information for future research in biomaterial related infection.

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Pp021-Mon Preoperative Systemic Inflammatory Response Is Associated With Perioperative Central Venous Catheter-Related Bloodstream Infection in Colorectal Cancer Patients Receiving Parental Nutrition

Cited by 4 publications

References 0 publications

Biomarkers for Evaluating the Inflammation Status in Patients with Cancer

Biomarkers for Evaluating the Inflammation Status in Patients with Cancer

Surgical Stress Response After Colorectal Resection

Effects of lipid emulsion on the formation of Escherichia coli –Candida albicans mixed species biofilm on PVC

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