PP-16 Does a wound healing environment and the inflammation associated with it promote melanoma invasion?

Katerinaki, E; Zhu, Ning; Lalla, Ravindra; Eves, Paula; Haycock, JW; Evans, Glenn F.; Ghanem, G.; Lorigan, Paul; Brown, Toby D.; MacNeil, S

doi:10.1034/j.1600-0749.2003.08381.x

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2004

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“…Because the epidermis is devoid of lymphatics and blood vessels, tumor invasion of the dermis is required for the dissemination of malignant cells. Thus, interaction between the melanoma cells and subcutaneous tissues modulates the metastization (1,2). Invasion of the subcutaneous tissues by melanoma cause local inflammatory reactions; when massive inflammatory infiltration occurs, melanoma growth may be inhibited (3).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Granulocytes Decrease Subcutaneous Growth of Melanoma in Mice

Costa

Águas

2004

Inflammation

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Growing melanomas invade the subcutaneous tissues. We have compared the size of tumors implanted in the subcutaneous cavities of C57BL/6 mice where inflammatory reactions were induced before the injection of 5 x 10(5) melanoma cells (B16F10 cell line). Granulocytic inflammation of the subcutaneous cavities resulted in a significant decrease in the growth of the implanted melanomas, whereas monocytic inflammation had no effect on tumor growth. We conclude that granulocytes, but not monocytes/macrophages, have anti-tumor action on melanoma that invade the subcutaneous tissues.

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Section: Introductionmentioning

confidence: 99%