[PP.02.43]

Molchanova, O. V; Андреева, Г.; Britov, A. N.; Grishenkov, E A

doi:10.1097/01.hjh.0000467783.24788.32

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, results indicated that other factors may be associated with the findings in the studies, such as duration of follow-up and measures adjusted for, such as calcium, sodium, potassium, fiber, exercise, cholesterol, saturated fat intake and smoking, and the combination of several ions supplementation [48]. In our meta-analysis, subgroup analysis showed that after adjusting separately for these factors, the inverse association presents a little lower than that without adjustment (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies

Han

Fang

Wei³

et al. 2017

Nutr J

115

View full text Add to dashboard Cite

BackgroundThe findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum magnesium concentration and the risk of hypertension. We aimed to review the evidence from prospective cohort studies and perform a dose-response meta-analysis to investigate the relationship between dietary magnesium intake and serum magnesium concentrations and the risk of hypertension.MethodsWe searched systematically PubMed, EMBASE and the Cochrane Library databases from October 1951 through June 2016. Prospective cohort studies reporting effect estimates with 95% confidence intervals (CIs) for hypertension in more than two categories of dietary magnesium intake and/or serum magnesium concentrations were included. Random-effects models were used to combine the estimated effects.ResultsNine articles (six on dietary magnesium intake, two on serum magnesium concentration and one on both) of ten cohort studies, including 20,119 cases of hypertension and 180,566 participates, were eligible for inclusion in the meta-analysis. We found an inverse association between dietary magnesium intake and the risk of hypertension [relative risk (RR) = 0.92; 95% CI: 0.86, 0.98] comparing the highest intake group with the lowest. A 100 mg/day increment in magnesium intake was associated with a 5% reduction in the risk of hypertension (RR = 0.95; 95% CI: 0.90, 1.00). The association of serum magnesium concentration with the risk of hypertension was marginally significant (RR = 0.91; 95% CI: 0.80, 1.02).ConclusionsCurrent evidence supports the inverse dose-response relationship between dietary magnesium intake and the risk of hypertension. However, the evidence about the relationship between serum magnesium concentration and hypertension is limited.Electronic supplementary materialThe online version of this article (doi:10.1186/s12937-017-0247-4) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%