Powszechny niedobór witaminy D u dorosłych z województwa pomorskiego po miesiącach niskiego i wysokiego promieniowania UVB

Kmieć, Piotr; Żmijewski, Michał A.; Lizakowska-Kmieć, Maria; Sworczak, Krzysztof

doi:10.5603/ep.2015.0006

Cited by 18 publications

(14 citation statements)

References 23 publications

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“…Although the beneficial effect of vitamin D on human health is already well established, vitamin D deficiencies have become a global problem (Holick, 2006;Hosseinnezhad & Holick, 2013). Recent studies conducted in Poland also underlined this issue (Kmieć et al, 2014;Pludowski et al, 2014, Kmieć et al, 2015. Furthermore, seasonal changes in vitamin D level that were observed, pointed out the necessity of its proper supplementation, especially in the winter season (Pludowski et al, 2013, Kmieć et al, 2015.…”

Section: Introductionmentioning

confidence: 92%

Vitamin D in the skin physiology and pathology.

2016

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Vitamin D plays important, pleiotropic role in the maintenance of global homeostasis. Its influence goes far beyond the regulation of calcium and phosphorus balance, as diverse activities of vitamin D and its natural metabolites assure proper functioning of major human organs, including skin. Recently, we reviewed the current understanding of vitamin D impact on human health from historical perspective (Wierzbicka et al. (2014) The renaissance of vitamin D. Acta Biochim Pol 61: 679-686). This article focuses on its functions in the skin. The skin and its appendages, creates a platform connecting and protecting internal organs against, usually harmful, external environment. It uppermost layer - epidermis in order to maintain a protective barrier undergoes a constant exchange of cornified keratinocytes layer. Its disturbance leads to development of serious skin disorders including psoriasis, vitiligo, atopic dermatitis and skin cancer. All of those dermatopathologies have a huge impact on modern societies, affecting not only the physical, but also mental state of patients as well as their social status. Furthermore, multiple human systemic diseases (autoimmune, blood and digestive diseases) have skin manifestation, thus "condition of the skin" often reflects the condition and pathological changes within the internal organs. In humans, the skin is the natural source of vitamin D, which is produced locally from 7-dehydrocholesterol in photoreaction induced by ultraviolet B (UVB) radiation from the sun. It is also well established, that the process of proliferation and differentiation of keratinocytes is tightly regulated by calcium and the active form of vitamin D (1,25(OH)2D3). Thus, the skin physiology is inseparably connected with vitamin D production and activity. Unfortunately, UVB, which is required for vitamin D production, is also known as the main cause of a skin cancer, including melanoma. Here, we are going to review benefits of vitamin D and its analogues in the maintenance of epidermal barrier and its potential use in the treatment of common skin diseases.

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Section: Introductionmentioning

confidence: 92%

Vitamin D in the skin physiology and pathology.

2016

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“…The Institute of Medicine supports the key role of calcium and vitamin D in the maintenance of skeletal health and recommended a daily intake of 1.2 g of calcium and 800 IU of vitamin D for women in older age [5]. In Poland, 90% of people have insufficiency of vitamin D [23,24,38].…”

Section: Rycina 4 Zmiany Stężenia Całkowitej Witaminy D W Grupie 2 Pmentioning

confidence: 99%

“…In Europe, the mean serum 25(OH)D levels, reported in population-based studies, vary from 18 ng/mL (29 nmol/L) in Italy to 30 ng/mL (75 nmol/L) in Norway [20]. It has been observed that more than 40% of U.S. and European men and women, and more than 50% of postmenopausal women, are affected by vitamin D deficiency [7,21], including Poland, where it is found in approximately 90% of the general population [22][23][24]. In some populations, the deficit is ever stronger, e.g.…”

Section: Introductionmentioning

confidence: 99%

Ocena stężenia witaminy D u młodych zdrowych kobiet: skuteczność suplementacji witaminą D

Sewerynek¹,

Cieślak

Janik

et al. 2015

Endokrynologia Polska

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“…Vitamin D deficiency has been shown to be prevalent in Northern Poland [6], and summer sun exposure was not sufficient to fully eliminate it [7,8]. Furthermore, vitamin D deficiency was stated in up to 90% of Poland's adult population [9].…”

Section: Introductionmentioning

confidence: 99%