Vitamin D status including 3-epi-25(OH)D3 among adult patients with thyroid disorders during summer months

Kmieć, Piotr; Minkiewicz, Ilona; Rola, Rafał; Sworczak, Krzysztof; Żmijewski, Michał A.; Kowalski, Konrad

doi:10.5603/ep.a2018.0065

Cited by 20 publications

(17 citation statements)

References 27 publications

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“…A total of 35 studies (42 arms), including 28 case-control [ 17 , 25 – 51 ] and 7 cross-sectional studies [ 52 – 58 ] with sample sizes varying from 38 to 6685 subjects were included in our systematic review. The selected studies were published between 1980 and 2018.…”

Section: Resultsmentioning

confidence: 99%

“…The selected studies were published between 1980 and 2018. Among these, 9 studies were from Turkey [ 26 , 34 , 36 , 37 , 39 , 42 , 43 , 48 , 49 ], 3 each from Saudi Arabia [ 17 , 32 , 35 ], Poland [ 38 , 52 , 59 ], China [ 27 , 28 , 51 ] and Korea [ 54 , 55 , 58 ], 2 each from Egypt [ 50 , 60 ] and Italy [ 40 , 57 ] and one each from Belgium [ 25 ], Canada [ 33 ], Brazil [ 44 ], Japan [ 47 ], India [ 45 ], Sweden [ 46 ], Thailand [ 53 ], Greece, United States [ 56 ], and Ukraine [ 31 ]. Among the 35 studies, 29 recruited both genders [ 25 , 27 – 32 , 34 – 41 , 43 – 46 , 48 – 56 , 58 ], 4 only women [ 17 , 42 , 47 , 57 ], and 2 studies did not report the gender [ 26 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among the 35 studies, 29 recruited both genders [ 25 , 27 – 32 , 34 – 41 , 43 – 46 , 48 – 56 , 58 ], 4 only women [ 17 , 42 , 47 , 57 ], and 2 studies did not report the gender [ 26 , 33 ]. Eighteen studies mentioned BMI [ 27 , 28 , 30 , 31 , 33 , 35 , 36 , 40 , 45 , 47 , 50 – 53 , 55 – 58 ] and 26 studies pointed to the time of year when samples were collected [ 17 , 27 – 30 , 32 , 33 , 36 , 38 – 47 , 49 , 51 , 53 – 55 , 58 , 61 , 62 ]. All the included studies assessed the serum levels of 25(OH) D and none of them examined the dietary intake of vitamin D in participants.…”

Section: Resultsmentioning

confidence: 99%

“…All the included studies assessed the serum levels of 25(OH) D and none of them examined the dietary intake of vitamin D in participants. Additionally, among the selected studies, 6 [ 52 – 54 , 56 – 58 ] were considered as high quality and the rest [ 17 , 25 – 51 , 55 ] had moderate quality. Table 1 gives an outline of the characteristics of the included studies.…”

Section: Resultsmentioning

confidence: 99%

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Vitamin D and thyroid disorders: a systematic review and Meta-analysis of observational studies

et al. 2021

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Background The contribution of vitamin D to thyroid disorders has received paramount attention; however, results are mixed. Hence, we designed a systematic review and meta-analysis to obtain a definitive conclusion. Methods The search included PubMed, ISI Web of Science, Scopus, and Google Scholar databases up to March 2021 to collect available papers reporting the relationship between serum levels of vitamin D and thyroid disorders. The pooled effect was reported as weighted mean difference (WMD) and 95% confidence interval (CI). Results Out of 6123 datasets, 42 were eligible to get into this systematic review and meta-analysis. Serum vitamin D was markedly lower in autoimmune thyroid diseases (AITD) (WMD − 3.1 ng/dl; 95% CI, − 5.57 to − 0.66; P = 0.013; I2 = 99.9%), Hashimoto’s thyroiditis (HT) (WMD − 6.05 ng/dl; 95% CI, − 8.35 to − 3.75; P < 0.001; I2 = 91.0%) and hypothyroidism patients (WMD − 13.43 ng/dl; 95% CI, − 26.04 to − 0.81; P = 0.03; I2 = 99.5%), but not in subjects with Graves’ disease (GD) (WMD − 4.14 ng/dl; 95% CI, − 8.46 to 0.17; P = 0.06; I2 = 97.5%). Conclusions Our findings suggested lower vitamin D levels in patients with hypothyroidism, AITD, and HT compared to healthy subjects. However, the link between serum vitamin D and GD was only significant among subjects ≥40 years old.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Vitamin D and thyroid disorders: a systematic review and Meta-analysis of observational studies

et al. 2021

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“…There are several HPLC-MS/MS methods for analysis of vitamin D in human serum, plasma, dry blood spots and milk [16,19,[39][40][41][42][43][44][45][46][47][48][49][50][51][52]. Moreover, application of supercritical fluid chromatography (SFC) with MS/MS detection was reported [13,53].…”

Section: Hplc-ms/msmentioning

confidence: 99%

Clinical Significance of Analysis of Vitamin D Status in Various Diseases

et al. 2020

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Vitamin D plays a role not only in the proper functioning of the skeletal system and the calcium-phosphate equilibrium, but also in the immune system, the cardiovascular system and the growth and division of cells. Although numerous studies have reported on the analysis of vitamin D status in various groups of patients, the clinical significance of measurements of vitamin D forms and metabolites remains ambiguous. This article reviews the reports analyzing the status of vitamin D in various chronic states. Particular attention is given to factors affecting measurement of vitamin D forms and metabolites. Relevant papers published during recent years were identified by an extensive PubMed search using appropriate keywords. Measurement of vitamin D status proved to be a useful tool in diagnosis and progression of metabolic syndrome, neurological disorders and cancer. High performance liquid chromatography coupled with tandem mass spectrometry has become the preferred method for analyzing the various forms and metabolites of vitamin D in biological fluids. Factors influencing vitamin D concentration, including socio-demographic and biochemical factors as well as the genetic polymorphism of the vitamin D receptor, along with vitamin D transporters and enzymes participating in vitamin D metabolism should be considered as potential confounders of the interpretation of plasma total 25(OH)D concentrations.

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Vitamin D deficiency and thyroid autoantibody fluctuations in patients with Graves’ disease – A mere coincidence or a real relationship?

Płazińska

Czarnywojtek

Sawicka‐Gutaj

et al. 2020

Advances in Medical Sciences

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Vitamin D status including 3-epi-25(OH)D3 among adult patients with thyroid disorders during summer months

Cited by 20 publications

References 27 publications

Vitamin D and thyroid disorders: a systematic review and Meta-analysis of observational studies

Vitamin D and thyroid disorders: a systematic review and Meta-analysis of observational studies

Clinical Significance of Analysis of Vitamin D Status in Various Diseases

Vitamin D deficiency and thyroid autoantibody fluctuations in patients with Graves’ disease – A mere coincidence or a real relationship?

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