Power Consumption in Gas-Liquid Contactors Agitated by Double-Stage Rushton Turbines

Markopoulos, Joannis; Pantuflas, Emmanuel

doi:10.1002/1521-4125(200111)24:11<1147::aid-ceat1147>3.0.co;2-9

Cited by 20 publications

(13 citation statements)

References 6 publications

(8 reference statements)

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“…The calculation was carried out as follows: [5,12,24], and presented as a function of impeller interspacing, H, and d i /d T [24]. Although torque measurement is a more reliable method for power input determination, this was not considered within our study.…”

Section: Methodsmentioning

confidence: 99%

“…According to Henzler [5] and Markopoulos [12], a correction on Np due to impeller spacing is needed for both bioreactors since h/d T < 0.75 [5] and h < 1.65 d i [12]. This correction was calculated according to Hudcova et al [24], who showed a relationship for power number ratio Np 2 /Np 1 and the ratio of impeller interspacing to tank diameter h/d T in two impeller systems.…”

Section: Bioreactor Characterizationmentioning

confidence: 99%

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Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture

Barradas

Jandt

Phan

et al. 2012

Engineering in Life Sciences

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Development of bioprocesses with mammalian cell culture deals with different bioreactor types and scales. The bioreactors might be intended for generation of cell inoculum and production, research, process development, validation, or transfer purposes. During these activities, not only the difficulty of up and downscaling might lead to failure of consistency in cell growth, but also the use of different bioreactor geometries and operation conditions. In such cases, criteria for bioreactor design and process transfer should be carefully evaluated in order to select appropriate cultivation parameters. In this work, power input, mixing time, impeller tip speed, and Reynolds number have been compared systematically for the cultivation of the human cell line AGE1.HN within three partner laboratories using five different bioreactor systems. Proper operation ranges for the bioreactors were identified using the maximal cell‐specific growth rate (μmax) as indicator. Common optimum values for process transfer criteria were found in these geometrically different bioreactors, in which deviations of μmax between cultivation systems can be importantly reduced. The data obtained in this work are used for process standardization and comparability of results obtained in different bioreactor systems, i.e. to guarantee lab‐to‐lab consistency for systems biology approaches using mammalian cells.

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Section: Methodsmentioning

confidence: 99%

Section: Bioreactor Characterizationmentioning

confidence: 99%

Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture

Barradas

Jandt

Phan

et al. 2012

Engineering in Life Sciences

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“…At an impeller spacing of DH ³ 2 d, for impeller diameters d = 0.06 and d = 0.08 m, and DH ³ 1.54 d, for impeller diameter d = 0.10 m, the double-stage Rushton turbines give a slightly better gas dispersion than the single turbines at the same rotational speed. However, as reported in the literature [16,17], for these impeller spacing, the two impellers are acting independently and the power drawn by the double impellers is approximately twice that of the single impeller systems. So the slightly better dispersion conditions, observed in the double impeller systems, cannot be regarded from first sight as advantageous.…”

Section: Resultsmentioning

confidence: 99%

“…The accuracy of the method used was estimated to be better than 10 %. A detailed presentation of the experimental set-up is given in previous work [16].…”

Section: Methodsmentioning

confidence: 96%

Dispersion Characteristics of Gas-Liquid Contactors Agitated by Single and Double-Stage Rushton Turbines

Babalona¹,

Paras

Markopoulos

2002

Chem. Eng. Technol.

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“…These aerated agitated tanks can be equipped with a number of different or identical impellers. These multi‐impeller mixing systems can provide a higher bubble surface area per unit volume, more uniform distribution of the shear rate within the tank, and a higher gas utilization rate . Nonetheless, previous studies demonstrated that traditional mixers which were equipped with multiple agitators located on the same shaft still show some failures to distribute the gas evenly throughout tanks containing viscous Newtonian and non‐Newtonian fluids.…”

Section: Introductionmentioning

confidence: 99%

Hydrodynamic characteristics of an aerated coaxial mixing vessel equipped with a pitched blade turbine and an anchor

Hashemi

Ein‐Mozaffari

Upreti

et al. 2017

J of Chemical Tech & Biotech

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Background In this work, computational fluid dynamics (CFD) simulation of an aerated coaxial mixing vessel composed of a centered impeller and a wall scraping anchor was conducted to investigate the effects of speed ratio, rotation modes (co‐rotating and counter‐rotating), and fluid viscosity on the local and global gas holdup values, flow pattern within the vessel, and turbulent kinetic energy. To validate the developed model, simulated gas holdup and gassed power uptake were compared with the measured experimental values. To gather experimental gas holdup values, an electrical resistance tomography technique was utilized. Results The results demonstrated that the co‐rotating coaxial mixer with a speed ratio higher than 10 provided a higher gas volume fraction within the vessel. It was also shown that the turbulent kinetic energy attained in the counter‐rotating mode was lower than those for the co‐rotating coaxial mixer in most regions within the mixing tank, especially near the vessel walls. The size and the number of circulation loops developed within the coaxial mixer were affected by the speed ratio. Conclusion It was demonstrated that speed ratio and rotation mode of the impellers affected the hydrodynamics developed within the aerated coaxial mixer. © 2017 Society of Chemical Industry

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Power Consumption in Gas-Liquid Contactors Agitated by Double-Stage Rushton Turbines

Cited by 20 publications

References 6 publications

Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture

Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture

Dispersion Characteristics of Gas-Liquid Contactors Agitated by Single and Double-Stage Rushton Turbines

Hydrodynamic characteristics of an aerated coaxial mixing vessel equipped with a pitched blade turbine and an anchor

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