Powder metallurgical low-modulus Ti–Mg alloys for biomedical applications

Liu, Yong; Li, Kaiyang; Luo, Tao; Song, Min; Wu, Hong; Xiao, Jian; Tan, Yun; Cheng, Ming; Chen, Bing; Niu, Xinrui; Hu, Rong; Li, Xiaohui; Tang, Huiping

doi:10.1016/j.msec.2015.06.010

Cited by 82 publications

(30 citation statements)

References 45 publications

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“…To improve the bioactivity of Ti, the further modification of Ti is one of the most active research areas [ 13 ]. Several techniques have been developed to fabricate Ti—Mg composites through the combination of Ti and Mg, such as infiltration, extrusion and spark plasma sintering (SPS) [ [14] , [15] , [16] ]. The SPS technique utilizes a pulsed direct current simultaneously with an uni-axial pressure to sinter powders [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application

Ouyang

Huang

Liu

et al. 2019

Bioactive Materials

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In this work, Ti—Mg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to Ti—Mg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was employed, and Ti—Mg MMCs implants were embedded into the femur condyles. Results showed that Ti—Mg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure Ti. The micro-computed tomography (Micro-CT) results showed that the volume of bone trabecula was significantly more abundant around Ti—Mg implants than around Ti implants, indicating that more active new-bone formed around Ti—Mg MMCs implants. Hematoxylin-eosin (H&E) staining analysis revealed significantly greater osteointegration around Ti—Mg implants than that around Ti implants.

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Section: Introductionmentioning

confidence: 99%

Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application

Ouyang

Huang

Liu

et al. 2019

Bioactive Materials

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“…In addition, the Ti-Mg alloy is also a biodegradable implant material, and the Mg in Ti-Mg alloys is biodegradable in the human body. The degradation process generates numerous pores, which facilitate the growth of cells and improve the bonding between the bones and implant materials [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, Ti-Mg alloys cannot be synthesized by conventional casting methods. Several techniques, including severe plastic deformation [12,13], infiltration [6], and sintering [5,14], have been developed to fabricate Ti-Mg composite materials using blended Ti and Mg powders. However, large Mg particles are always present in these ex-situ Ti-Mg composite materials, which results in extremely high Mg degradation rate in physiological conditions.…”

Section: Introductionmentioning

confidence: 99%

Effect of Deposition Parameters on Microstructure of the Ti-Mg Immiscible Alloy Thin Film Deposited by Multi-Arc Ion Plating

Wei

Dong

et al. 2019

Metals

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Ti-Mg immiscible alloy thin films were prepared using a multi-arc ion plating technique with various deposition parameters. The surface and cross-section morphologies, crystal structures, and chemical compositions of the Ti-Mg films were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), and transmission electron microscopy (TEM). The influence of the substrate negative bias voltage and Ar gas pressure on the microstructure of the Ti-Mg films was systematically studied. Mg atoms were incorporated into the Ti lattice to form an FCC immiscible supersaturated solid solution phase in the thin film. Microparticles were observed on the film surface, and the number of microparticles could be significantly reduced by decreasing the substrate bias voltage and increasing the Ar gas pressure. The appropriate substrate bias voltage and Ar gas pressure increased the deposition rate. The TEM results indicated that columnar, nanolayer, and equiaxed nanocrystals were present in the thin films. Ti and Mg fluctuations were still evident in the nanoscale structures.

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“…13) As Al and V are toxic and allergy-causing elements, the Ti6Al4V extra-low interstitial (ELI, mass%), which is a typical material for implant applications, was considered to cause damage to the body. 4,5) Recently, a series of ¢-type titanium alloys have been developed by adding Nb, Zr, Mo, Ta, and Sn. These elements are nontoxic and thus do not cause adverse reactions in the human body.…”

Section: Introductionmentioning

confidence: 99%

Effects of Fe on Microstructures and Mechanical Properties of Ti–15Nb–25Zr–(0, 2, 4, 8)Fe Alloys Prepared by Spark Plasma Sintering

Yuan

et al. 2019

Mater. Trans.

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Biomedical Ti15Nb25Zr(0, 2, 4, 8)Fe (mol%) alloys are prepared by mixing pure element powders and spark plasma sintering (SPS). Specimens with diameters of 20 mm and thicknesses of 3 mm are obtained by sintering at 1000°C for 10 min followed by cooling in the furnace. Some of the specimens are then heat-treated at 900°C for 1 h followed by water quenching. Zr and Fe are dissolved in Ti; however, segregation of Nb is observed in all of the alloys. The ¢ and ¡AA phases are observed in the as-sintered and heat-treated specimens owing to the insufficient diffusion of the alloying elements. Fe stabilizes the ¢ phase and provides a solution-strengthening effect. With the increase in the Fe content in the as-sintered specimen, the compressive strength and micro-Vickers hardness are improved in the Ti15Nb25Zr(0, 2, 4)Fe alloys and slightly decreased in Ti15Nb25Zr8Fe. The as-sintered Ti15Nb25Zr4Fe alloy exhibits the maximum compressive strength of 1740 MPa. Although the plasticity is decreased by the Fe addition, a fracture strain of approximately 17% is obtained for Ti15Nb25Zr4Fe, indicating a good plasticity. The heat treatment cannot eliminate the segregation of Nb, but can improve the plasticity and slightly increase the strengths of Ti 15Nb25Zr(0, 2, 4)Fe. Moreover, the heat-treated Ti15Nb25Zr8Fe exhibits a high strength of approximately 1780 MPa and fracture strain of approximately 19%. Therefore, good comprehensive mechanical properties, including high strengths, high hardnesses, and good plasticities, can be obtained in Fe-added ¢-Ti alloys prepared by SPS and subsequent optional short heat treatment.

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Powder metallurgical low-modulus Ti–Mg alloys for biomedical applications

Cited by 82 publications

References 45 publications

Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application

Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application

Effect of Deposition Parameters on Microstructure of the Ti-Mg Immiscible Alloy Thin Film Deposited by Multi-Arc Ion Plating

Effects of Fe on Microstructures and Mechanical Properties of Ti–15Nb–25Zr–(0, 2, 4, 8)Fe Alloys Prepared by Spark Plasma Sintering

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