Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application

Ouyang, Sheng; Huang, Qianli; Liu, Yong; Ouyang, Zhengxiao; Liang, Luxin

doi:10.1016/j.bioactmat.2018.12.001

Cited by 33 publications

(23 citation statements)

References 22 publications

(26 reference statements)

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“…As orthopedic and spinal implants for PAEK, concerns raised regarding the new bone formation and osseointegration, which has been one of the critical issues for long-term success rates of orthopedic implants [ 13 ]. Good osteointegration performance is necessary for a permanent orthopedic device, because the osteointegration will directly impact the initial and long-term stability of the implant [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Mei

Qian

et al. 2021

Bioactive Materials

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Polyetherketoneketone (PEKK) exhibits admirable biocompatibility and mechanical performances but bioinert while tantalum (Ta) possesses excellent osteogenesis and osseointegration but high elastic modulus and density, and processing is too difficult and expensive. In the present study, combining of the advantages of both PEKK and Ta, implantable composites of PEKK/Ta were fabricated by blending PEKK with Ta microparticles of 20 v% (PT20) and 40 v% (PT40) content. In comparison with PT20 and PEKK, the surface hydrophilicity, surface energy, roughness and proteins adsorption as well as mechanical performances of PT40 significantly increased because of the higher Ta particles content in PEKK. Furthermore, PT40 exhibited the mechanical performances (e.g., compressive strength and modulus of elasticity) close to the cortical bone of human. Compared with PT20 and PEKK, PT40 with higher Ta content remarkably enhanced the responses (including adhesion, proliferation and osteogenic differentiation) of MC3T3-E1 cells in vitro . Moreover, PT40 markedly improved bone formation as well as osseointegration in vivo . In short, incorporation of Ta microparticles into PEKK created implantable composites with improved surface performances, which played key roles in stimulating cell responses/bone formation as well as promoting osseointegration. PT40 might have great potential for bear-loading bone substitute.

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Section: Introductionmentioning

confidence: 99%

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Mei

Qian

et al. 2021

Bioactive Materials

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“…Mg is also biodegradable, and thus, this composite is ideal for orthopedic implants. Not only does its addition adjust pure titanium's properties to approach that of bone but it also allows for Mg degradation over time with the resulting structure having good osteointegration [73][74][75][76][77]. Thus, the increased corrosion rate of the Ti + Mg composite is advantageous for such applications.…”

Section: Titaniummentioning

confidence: 99%

A Review on Corrosion and Wear of Additively Manufactured Alloys

Renner

Jha

Chen

et al. 2021

Journal of Tribology

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Products made from additive manufacturing processes have attracted great attention in engineering, health care, and society at large. However, there is little knowledge about the failure of additively manufactured alloys, in particular, corrosion and wear seen in most engineering applications. The haphazard and inefficient usage of such alloys raised concerns about safety, compatibility, reliability, cost, and consumer satisfaction. To address those concerns, we studied the mechanisms of the most common failure modes, corrosion and wear, of alloys fabricated through additive manufacturing based on published literature. It was found that the processing conditions have profound influence on microstructure and thus corrosion and wear resistance of alloys. Because of the layered structure, the initiation and growth of both corrosion and wear exhibited anisotropic behavior. The insights from this review could be used as a reference of the state-of-the art and to help in the development of future additively manufactured alloys with improved corrosion and wear properties.

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“…Titanium added to iron, aluminium, vanadium, molybdenum, tantalum and other metals forms lightweight and strong alloys, commonly used in aerospace (jet engines, spacecraft and missiles), metallurgy processes, dental/medical applications (prostheses, orthopedic implants, dental and endodontic instruments and files, dental implants), the car industry, agriculture, the military, sporting goods, mobile phones, jewellery and other applications [3][4][5], as shown in Figure 1. For example, Ouyang et al, (2019) have shown that Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration (significantly higher around Ti-Mg than that around Ti implants) for orthopedic application [6]. Similarly, increased osseointegration has been observed on Ti 35 Zr 28 Nb alloy than that on pure titanium [7].…”

Section: Introductionmentioning

confidence: 99%

Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium Compounds

et al. 2020

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Titanium and its compounds are broadly used in both industrial and domestic products, including jet engines, missiles, prostheses, implants, pigments, cosmetics, food, and photocatalysts for environmental purification and solar energy conversion. Although titanium/titania-containing materials are usually safe for human, animals and environment, increasing concerns on their negative impacts have been postulated. Accordingly, this review covers current knowledge on the toxicity of titania and titanium, in which the behaviour, bioavailability, mechanisms of action, and environmental impacts have been discussed in detail, considering both light and dark conditions. Consequently, the following conclusions have been drawn: (i) titania photocatalysts rarely cause health and environmental problems; (ii) despite the lack of proof, the possible carcinogenicity of titania powders to humans is considered by some authorities; (iii) titanium alloys, commonly applied as implant materials, possess a relatively low health risk; (iv) titania microparticles are less toxic than nanoparticles, independent of the means of exposure; (v) excessive accumulation of titanium in the environment cannot be ignored; (vi) titanium/titania-containing products should be clearly marked with health warning labels, especially for pregnant women and young children; (vi) a key knowledge gap is the lack of comprehensive data about the environmental content and the influence of titania/titanium on biodiversity and the ecological functioning of terrestrial and aquatic ecosystems.

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Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application

Cited by 33 publications

References 22 publications

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

Implantable PEKK/tantalum microparticles composite with improved surface performances for regulating cell behaviors, promoting bone formation and osseointegration

A Review on Corrosion and Wear of Additively Manufactured Alloys

Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium Compounds

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