Powder Flow Studies IV

Gold, Gerald; Duvall, Ronald N.; Palermo, Blaze T.; Slater, James G.

doi:10.1002/jps.2600571227

Journal of Pharmaceutical Sciences

1968

DOI: 10.1002/jps.2600571227

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Powder Flow Studies IV

Gerald Gold

Ronald N. Duvall

Blaze T. Palermo

et al.

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1969

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Cited by 17 publications

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References 12 publications

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“…No correlation was proposed by them, but optimum amounts of glidants to be added to increase the free flowing nature of the granules through conical hopper were predicted. Flow of pharmaceutically important granules at lower pressure (10 psi) in a stainless steel conical hopper having interchangeable orifices was also studied by Gold et al 5. Easy flow of poorly flowing granules was reported but they did not present any mathematical equation for calculating the discharge rate.…”

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Flow of formulation granules through a conical hopper

Mazumder¹,

Rajan²,

Khanam³

et al. 2008

Indian J Pharm Sci

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Gravity flow characteristics of various pharmaceutical granules through static conical hoppers of different cone angles were studied. Mass flow rate depends on properties of granules and cone angles when environmental conditions such as temperature and relative humidity are kept within a fixed range. The granules were made with active pharmaceutical ingredients as per Indian pharmacopoeia with other additives like binders and diluents. Lubricants were added with the granules to observe their effects on mass flow rate. Magnesium stearate and colloidal silicon dioxide of different proportions were used as lubricants after granulation. A new dimensionally analyzed equation was developed to predict flow rate of the granules. The developed equation agreed well with the experimental data with a percentage deviation of ±10%.

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confidence: 99%

Flow of formulation granules through a conical hopper

Mazumder¹,

Rajan²,

Khanam³

et al. 2008

Indian J Pharm Sci

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Pharmaceutical Sciences—1968. A Literature Review of Pharmaceutics

Bernardo¹,

Russo²

1969

Journal of Pharmaceutical Sciences

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Utilization of the Solids Processor for Preparation of Tablet Granulations

Goodhart¹,

Draper²,

Ninger³

1970

Journal of Pharmaceutical Sciences

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Powder Flow Studies IV

Cited by 17 publications

References 12 publications

Flow of formulation granules through a conical hopper

Flow of formulation granules through a conical hopper

Pharmaceutical Sciences—1968. A Literature Review of Pharmaceutics

Utilization of the Solids Processor for Preparation of Tablet Granulations

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