Utilization of the Solids Processor for Preparation of Tablet Granulations

Intragranular solute migration in a test granulation dried by fluidization and vacuum tumbler drying

“…Wet granules from a sieve mesh 2800 pm were dried in a laboratory fluid bed dryer or in an evacuated vessel rocked back and forth in a water bath at 50" to simulate vacuum tumbling drying (Goodhart, Draper & Ninger, 1970). (200 g) with 50 ml of sodium chloride solution (lO%w/w) equivalent to 26.0 mg of salt per g dry weight.…”