Povidone–iodine solution: A potential antiseptic to minimize the risk of COVID-19? A narrative review

Castro-Ruiz, Carmen; Vergara‐Buenaventura, Andrea

doi:10.4103/jispcd.jispcd_304_20

Cited by 9 publications

(14 citation statements)

References 34 publications

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“…The concentration and duration of PVP-I can be decided based on the mucous and salivary flow of the individual. Since the flow rate of saliva in a hospital-bound semiconscious patient is low and clearance of PVP-I is slower than usual, prolonged exposure of PVP-I is indicated [69] , [70] . It is recommended that, for complete viral eradication, PVP-I products should be used for two weeks at least, or until local authorities control the risk of infectivity.…”

Section: Discussionmentioning

confidence: 99%

Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update

Chopra

Sivaraman

Radhakrishnan

et al. 2021

Japanese Dental Science Review

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Section: Discussionmentioning

confidence: 99%

Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update

Chopra

Sivaraman

Radhakrishnan

et al. 2021

Japanese Dental Science Review

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“…31 Castro mediante su investigación en pacientes con PCR positiva al SARS-CoV-2 evidenció una disminución estadísticamente significativa en la disminución de carga viral en el lapso de tres horas, concluyendo ser un protocolo profiláctico adecuado previo a la atención estomatológica. 32…”

Section: Discussionunclassified

Efficacy in reducing oral viral load (SARS-CoV-2) of three types of mouthwashes.Literature review

Fajardo-Sotamba¹,

Vásquez-Palacios²

2022

RevFacOdont

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In Wuhan-China, an outbreak of pneumonia of idiopathic origin was identified in December 2019; the causative agent was isolated in January 2020; a new variant of coronavirus (SARS-CoV-2) was declared by the World Health Organization (OMS) as coronavirus disease 2019 (COVID-19). Due to the ways of transmission this virus has shown a high ease of contagion, spreading rapidly, it is known that approximately 148 million infected and 3.012 million died from SARS-CoV-2, affecting more than 190 countries in 5 continents. It is important for health personnel due to the working conditions to which they are exposed, being this in order to the optimal conditions for the acquisition of this pathology. Objective: To compare the efficacy and efficiency of the use of mouthwashes: hydrogen peroxide, povidone iodine and chlorhexidine against SARS-CoV-2 viral load. Materials and methods: A search were carried out in the databases of PubMed, SAGE JOURNAL, ACP, Medigraphic, PMC, which were selected according to the inclusion criteria, obtaining 30 studies Results: Chlorhexidine (CHX) at concentrations of 0. 12% and 2% did not show a statistically significant index capable of inactivating SARS-CoV-2 viral load, Hydrogen peroxide (H2O2) showed minimal inactivation to SARS-CoV-2 virus at concentrations of 0. 5%, 1.25% or 1.5%, Povidone iodine (PVP-I) is able to inactivate SARS-CoV-2, at concentrations of 0.5%, 1.25% and 1.5%, in contact periods of 60 seconds, which reduces the transmission of SARS-CoV-2. Conclusion: It can be evidenced that the different mouthwashes with bactericidal or bacteriostatic effects are an important reference with the aim of protecting the professional as well asthe community. The rinse that showed the greatest effectiveness against SARS-CoV-2 virus was iodopovidone with the ability to inactivate the virus and thus prevent its spread.

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“…PVP-I is a proven antiseptic agent with excellent virucidal properties (99.99%) [25] , dilute solutions of PVP-I have historically been used in Asia to treat upper respiratory tract infections [26] . Antiseptic nasal and oral PVP-I solutions are effective in inactivating SARS-CoV-2 at a variety of concentrations after exposure times of 60 seconds [27,28] . Recent evidence has confirmed that mouthwash/gargling with 0.5% povidone-iodine (PVP-I) for 30 seconds can reduce SARS-CoV-2 virus infectivity below detectable levels [6] .…”

Section: Povidone Iodinementioning

confidence: 99%

Mouth rinses against SARS-CoV-2

Deutsch¹,

Contreras²,

Betancourt³

et al. 2022

Int. J. Appl. Dent. Sci.

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Introduction: Dentists worldwide are witnessing an uncertain professional situation during times of COVID-19 pandemic, therefore the identification of specific antiviral mouth rinses to reduce salivary viral load would contribute to reducing the pandemic. Objective: To analyze information regarding mouth rinses that help to reduce oral bacterial load of COVID-19 such as chlorhexidine, cetylpyridinium chloride, povidone iodine and hydrogen peroxide. Methodology: Articles on mouthwashes were analyzed in the databases PubMed, SCOPUS and Google academic with emphasis on the last 5 years. This was done with the words: COVID-19 and chlorhexidine", "cetylpyridinium chloride", "povidone iodine", "hydrogen peroxide. Results: Chlorhexidine has been shown to have a viral inactivation effect against SARS-CoV 2 and facilitates control of oral transmission. Concentrations of 0.05% cetylpyridinium chloride commonly used in mouthwashes are sufficient to promote membrane rupture of SARS-CoV-2. Povidone-iodine rapidly inactivates SARS-CoV-2 when applied for as little as 15 seconds. The indication for preoperative mouth rinsing with 1% hydrogen peroxide is recommended to reduce the SARS-CoV-2 viral load in saliva. Conclusion:Mouth rinses can inhibit or inactivate SARS-CoV-2, some being more effective and efficient than others. Chlorhexidine and iodine were found to be the most effective mouth rinses in lowering oral viral load, while cetylpyridinium chloride and hydrogen peroxide did not perform as well in comparison.

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Povidone–iodine solution: A potential antiseptic to minimize the risk of COVID-19? A narrative review

Cited by 9 publications

References 34 publications

Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update

Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? An evidence-based update

Efficacy in reducing oral viral load (SARS-CoV-2) of three types of mouthwashes.Literature review

Mouth rinses against SARS-CoV-2

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