Povidone iodine loaded film-forming topical gel and evaluation of its chemical stability

Abstract

The main aim of this study was to develop Povidone Iodine loaded ilmforming gel for excellent wound healing property with various formulations, and corresponding application strati ication was prepared with Povidone Iodine, polyethylene glycol-400, polyethylene glycol-4000, aloe vera, and honey. Povidone Iodine is a broad spectrum antiseptic for topical application in the treatment and prevention of infection in wounds. Among the antiseptic and antimicrobial substances, Povidone-Iodine still occupies its position of lasting importance in everyday human and veterinary medicine. Povidoneiodine products display the broadest spectrum of antimicrobial effect with high clinical ef icacy together with extremely low toxicity in clinical practice. The purpose served by dressing includes protecting wounds, promoting healing, and providing, retaining, or removing moisture. Wound repairing is a complex process involving an integrated response by many different cell types and growth factors to achieve rapid restoration of skin integrity and protective function after injury. In recent years, there have been tremendous advances in the design and composition of bandages and dressings, and there are numerous wound care materials. Some wound dressing types are biosynthetic dressings, composite dressings, gauze, hydrocolloid dressings, hydrogels, transparent ilms, etc. Povidone Iodine is completely soluble in cold and mild-warm water, ethyl alcohol, Iso propyl alcohol, Polyethylene glycol, and glycerol. The developed Povidone Iodine loaded ilm-forming gel was evaluated for their physical and chemical stability. The ilm-forming optimized gel formulation composed of povidone-iodine, polyethylene glycol-400, polyethylene glycol-4000, aloe vera, and honey and this composition provides suitable consistency, spreadability, and adhesiveness. The prepared trials were coded PGAH-01, PGAH-02, PGAH-03, PGAH-04, and PGAH-05, respectively. Among these all formulations, the PGAH-04 formulation parameters was found within the limit.

Alginate and its application to tissue engineering

“…Finally, the appropriate volume of glycerol was mixed with the prepared NaAlg/PVPI solution and allowed to dissolve under continuous stirring for about 1 h at normal room temperature. Then each film was cast by taking 10 ml of the solution and finally dried for 24 h under a chemical hood to get final film [26][27][28].…”

Development and Evaluation of a Polyvinylalcohol -Cellulose Derivative-Based Film with Povidone-Iodine Predicted for Wound Treatment

“…The dressings we prepared (with PVA-HPMC, as with other combinations described in the literature) are characterized by enhanced properties, i.e., swelling or flexibility relative to pure PVA [ 40 , 41 ]. Povidone-iodine (PVP-I) was selected as the active drug in films, as it displays the broadest spectrum of antimicrobial effects against bacteria, yeasts, molds, other fungi, and certain viruses, and at the same time, microbes lack resistance to the compound [ 42 , 43 , 44 , 45 , 46 ]. Kaeviad et al developed dental floss impregnated with PVP-I as a drug antimicrobial delivery system against periodontopathogenic bacteria.…”