Development and Evaluation of a Polyvinylalcohol -Cellulose Derivative-Based Film with Povidone-Iodine Predicted for Wound Treatment

Kida, Dorota; Gładysz, Olimpia; Szulc, Małgorzata; Zborowski, Jacek; Junka, Adam; Janeczek, Maciej; Lipińska, Anna; Skalec, Aleksandra; Karolewicz, Bożena

doi:10.3390/polym12061271

Cited by 17 publications

(10 citation statements)

References 42 publications

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“…The elemental analysis of EDX ( Figure S1, supplementary file ) recorded the signal of I beside that of O and C for hydrogel. In FTIR spectral analysis, absorption peak of C=O in PI (at 1627 cm −1 ) and was overlapped with that of Pe@CMP hydrogel [ 51 , 52 ]. Both of micrographs and FTIR spectra confirmed the loading of PI onto the hydrogel.…”

Section: Resultsmentioning

confidence: 99%

Controllable Release of Povidone-Iodine from Networked Pectin@Carboxymethyl Pullulan Hydrogel

Emam

Mohamed

2021

Polymers

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Povidone-iodine (PI) is a common antiseptic reagent which is used for skin infections and wound healing. The control release of PI is quite important to heal the deep and intense wounds. Herein, the preparation of biodegradable pectin@carboxymethyl pullulan (Pe@CMP) hydrogel was carried out and applied for controllable release of PI. CMP was synthesized by interaction of monochloroacetic acid with pullulan at different ratios. The Pe@CMP hydrogel was then prepared by crosslinking of pectin with CMP in presence of glutaraldehyde as cross linker. After carboxymethylation, COOH contents were enlarged to be 24.2–51.2 mmol/kg and degree of substitution was 0.44–0.93. The rheological properties of Pe@CMP hydrogel were enlarged by increment of pectin ratio. Swelling ratio in water (16.0–18.0%) was higher than that of artificial sweat (11.7–13.2%). Pe@CMP hydrogel containing 20% pectin, exhibited the lowest release and 57.7% from PI was released within 360 min. The biological activity of the released PI was monitored to be highly efficient. The kinetic of release was fitted well to the first ordered reaction and Higuchi models. The mechanism of release was explained by the swelling of hydrogel. The networked structure of hydrogel was opened by swelling and PI was released from the outer pores followed by inner pores, achieving the controllable release.

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Section: Resultsmentioning

confidence: 99%

Controllable Release of Povidone-Iodine from Networked Pectin@Carboxymethyl Pullulan Hydrogel

Emam

Mohamed

2021

Polymers

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“…The dried film is then cut into pieces of the desired size and adequately packaged. Finally, the resulting film carrier should not be exposed to ambient conditions for a prolonged period due to its susceptibility to drying, evaporation of the residual solvent and reduced flexibility, as well as to mechanical damage in the form of chipping or micro-cracking [31][32][33]. The quality of the final product prepared by solvent casting is influenced by the properties of the polymers used to prepare the casting compounds, such as molecule structure, transverse dimension, chain length and flexibility.…”

Section: Solvent-casting Methods (Scm)mentioning

confidence: 99%

“…It has been reported that, for example, PVP mixed with cellulose derivatives such as ethyl cellulose and HPC can produce films with increased flexibility and softer, more durable properties [37]. Kida et al [31] report fabricating matrices based on polyvinyl alcohol (PVA) with cellulose derivatives, i.e., hydroxypropyl methylcellulose (HPMC) or sodium carboxymethyl cellulose (CMC). PVA has excellent membrane-forming properties and has been blended with selected swelling and gelling cellulose derivatives to tailor the mechanical and physicochemical properties of the developed polymer membranes to the application requirements.…”

Section: Solvent-casting Methods (Scm)mentioning

confidence: 99%

Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers

et al. 2023

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The development of polymer matrices as dental drug carriers takes into account the following technological aspects of the developed formulations: the composition and the technology used to manufacture them, which affect the properties of the carriers, as well as the testing methods for assessing their behavior at application sites. The first part of this paper characterizes the methods for fabricating dental drug carriers, i.e., the solvent-casting method (SCM), lyophilization method (LM), electrospinning (ES) and 3D printing (3DP), describing the selection of technological parameters and pointing out both the advantages of using the mentioned methods and their limitations. The second part of this paper describes testing methods to study the formulation properties, including their physical and chemical, pharmaceutical, biological and in vivo evaluation. Comprehensive in vitro evaluation of carrier properties permits optimization of formulation parameters to achieve prolonged retention time in the dynamic oral environment and is essential for explaining carrier behavior during clinical evaluation, consequently enabling the selection of the optimal formulation for oral application.

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“…The same polysaccharide, in combination with PVA, was used to obtain films by solvent casting and their physical–mechanical characteristics, morphology, mechanical properties, and disintegrating time, were evaluated. The successful incorporation of povidone-iodine and the ability of the system to deliver the drug consistently recommend it for applications in the treatment of periodontitis [ 69 ].…”

Section: Polymer–drug Systemsmentioning

confidence: 99%

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

et al. 2021

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Periodontal diseases are worldwide health problems that negatively affect the lifestyle of many people. The long-term effect of the classical treatments, including the mechanical removal of bacterial plaque, is not effective enough, causing the scientific world to find other alternatives. Polymer–drug systems, which have different forms of presentation, chosen depending on the nature of the disease, the mode of administration, the type of polymer used, etc., have become very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles, implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on the surface. Biologically active compounds can also be associated directly with the polymer chains by covalent or ionic binding (polymer–drug conjugates). Not just any polymer can be used as a support for drug combination due to the constraints imposed by the fact that the system works inside the body. Biopolymers, especially polysaccharides and their derivatives and to a lesser extent proteins, are preferred for this purpose. This paper aims to review in detail the biopolymer–drug systems that have emerged in the last decade as alternatives to the classical treatment of periodontal disease.

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Development and Evaluation of a Polyvinylalcohol -Cellulose Derivative-Based Film with Povidone-Iodine Predicted for Wound Treatment

Cited by 17 publications

References 42 publications

Controllable Release of Povidone-Iodine from Networked Pectin@Carboxymethyl Pullulan Hydrogel

Controllable Release of Povidone-Iodine from Networked Pectin@Carboxymethyl Pullulan Hydrogel

Technological Aspects and Evaluation Methods for Polymer Matrices as Dental Drug Carriers

Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis

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