Pouteria torta epicarp as a useful source of α-amylase inhibitor in the control of type 2 diabetes

Isolasi dan identifikasi spesies mikroalga air tawar sebagai antioksidan dan antihiperglikemik

“…Sebuah penelitian melaporkan bahwa proses fraksinasi memberikan nilai bioaktivitas yang bagus dimana Pouteria torta yang awalnya dimaserasi dengan etanol memberikan nilai IC 50 sebesar 73,6 µg/mL, tetapi saat ekstrak etanol difraksi sehingga menghasilkan 8 fraksi, setiap fraksi memberikan kemampuan inhibisi αamilase yang berbeda. Fraksi 2 dan fraksi 8 tidak menghasilkan aktivitas inhibisi, fraksi 6 memberikan aktivitas inhibisi tertinggi yaitu 77% dengan nilan IC 50 9 µg/mL (Sales et al, 2017). Aktivitas enzim diukur berdasarkan hasil absorbansi p-nitrofenol.…”

UPLC-QTOF-MS Analysis of Extracts from the Leaves of <i>Pouteria caimito</i> (Sapotaceae) and Their Antioxidant Activity

“…In addition to their commercial importance, several species have been used in folk medicine to treat fevers, inflammations, ulcers, diabetes and nausea, among other applications [4] [5]. In addition, the extracts, semipurified fractions and isolated substances from the Pouteria species show anti-inflammatory activity [6], inhibition of the α-amylase and β-glucosidase enzymes [7] and antidiabetic activity [8]. Despite the occurrence of bioactive substances of pharmacological interest, such as carotenoids, flavonoids, triterpenes and cyanogenic glycosides, only about 15 Pouteria species have been investigated from a chemical point of view [5] [9] [10].…”

α‐Amylase and tyrosinase inhibitory activities, phenolic contents, and antioxidant capacities of wild and cultivated blueberries

“…Inhibition of α‐amylase would slow the degradation of starch, thus reducing glucose release and controlling postprandial hyperglycemia (Ozer et al., 2018; Tan & Chang, 2017). One approach for treating type 2 diabetes is to inhibit the activities of carbohydrate‐hydrolyzing enzymes (de Sales et al., 2017; Johnson et al., 2011). Some commercial drugs characterized as carbohydrate‐hydrolyzing enzyme inhibitors (e.g., acarbose, voglibose, and miglitol) have been developed for diabetic patients; however, these drugs usually have side effects such as abdominal discomfort and diarrhea (de Sales et al., 2017; He et al., 2017; Lordan et al., 2013).…”

“…One approach for treating type 2 diabetes is to inhibit the activities of carbohydrate‐hydrolyzing enzymes (de Sales et al., 2017; Johnson et al., 2011). Some commercial drugs characterized as carbohydrate‐hydrolyzing enzyme inhibitors (e.g., acarbose, voglibose, and miglitol) have been developed for diabetic patients; however, these drugs usually have side effects such as abdominal discomfort and diarrhea (de Sales et al., 2017; He et al., 2017; Lordan et al., 2013). Therefore, it is important to find α‐amylase inhibitors from natural plants.…”