Pothomorphe umbellata Extract Prevents α-Tocopherol Depletion After UV-irradiation

Röpke, Cristina Dislich; Meirelles, Renata; Silva, Vanessa V. Da; Sawada, Tânia Cristina Higashi; Barros, S. B. M.

doi:10.1562/0031-8655(2003)0780436pueptd2.0.co2

Cited by 13 publications

(16 citation statements)

References 30 publications

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“…Thus, screenings of water, water-alcohol, hexane and ethanol extracts for in vitro antiplasmodial activity in blood stages of P. falciparum revealed extracts exhibiting IC 50 as low as 3.7 μg/mL (Atindehou et al, 2004). There is ample evidence in the literature on P. peltatum and P. umbellatum (Ropke et al, 2003Noriega et al, 2005) which is reinforced by our own experience in the laboratory (with P. peltatum) that extracts prepared with solvents of differing polarity contain significant and variable amounts of the secondary metabolite 4-NC (Pinto et al, 2010) which previous studies have shown to be an in vitro inhibitor of chloroquine-resistant K1 P. falciparum (Andrade-Neto et al, 2007).…”

Section: Discussionmentioning

confidence: 87%

In Vivo and In Vitro Antimalarial Activity of 4‐Nerolidylcatechol

Silva

Pinto

Pohlit

et al. 2011

Phytotherapy Research

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4-Nerolidylcatechol (4-NC) isolated from Piper peltatum L. (Piperaceae) was evaluated for in vitro antiplasmodial activity against Plasmodium falciparum (cultures of both standard CQR (K1) and CQS (3D7) strains and two Amazonian field isolates) and for in vivo antimalarial activity using the Plasmodium berghei-murine model. 4-NC exhibits significant in vitro and moderate in vivo antiplasmodial activity. 4-NC administered orally and subcutaneously at doses of 200, 400 and 600 mg/kg/day suppressed the growth of P. berghei by up to 63% after four daily treatments (days 1-4). Also, 4-NC exhibited important in vitro antiplasmodial activity against both standard and field P. falciparum strains in which 50% inhibition of parasite growth (IC(50) ) was produced at concentrations of 0.05-2.11 μg/mL and depended upon the parasite strain. Interestingly, healthy (non-infected) mice that received 4-NC orally presented (denatured) blood plasma which exhibited significant in vitro activity against P. falciparum. This is evidence that mouse metabolism allows 4-NC or active metabolites to enter the blood. Further chemical and pharmacological studies are necessary to confirm the potential of 4-NC as a new antimalarial prototype.

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Section: Discussionmentioning

confidence: 87%

In Vivo and In Vitro Antimalarial Activity of 4‐Nerolidylcatechol

Silva

Pinto

Pohlit

et al. 2011

Phytotherapy Research

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“…23 In a previous work we found that the P. umbellata extract was able to prevent skin a-tocopherol from depletion after acute UVB irradiation. 24 Alpha-tocopherol depletion in the skin of UV-irradiated mice can lead to disturbances in the cellular redox homeostasis, which in turn can contribute to premature ageing. It has been shown that ROS play an important role in the upregulation and activation of extracellular matrixdegrading metalloproteinases and, futhermore, are able to attack and destroy per se several extracellular matrix proteins.…”

Section: Discussionmentioning

confidence: 99%

“…The final concentration of 4-nerolidylcathecol in the crude extract was 25.4% (w ⁄ w), as evaluated by HPLC with electrochemical detection as previously described. 15,16…”

Section: Extract Preparationmentioning

confidence: 99%

“…14 In our previous study, skin alpha-tocopherol concentrations were significantly decreased ( 40%, P < 0.01) in the irradiated mice control groups, but were totally preserved in the P. umbellata treated group (100%, P > 0.05). 15 Based on these data, and on previous cutaneous absorption studies of 4-nerolidylcathecol, 16 we decided to investigate the potential beneficial effects of P. umbellata topical application on skin chronically exposed to UVB light.…”

Section: Introductionmentioning

confidence: 99%

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Photoprotective effect of Pothomorphe umbellata root extract against ultraviolet radiation induced chronic skin damage in the hairless mouse

et al. 2005

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In this study we evaluated the activity of Pothomorphe umbellata root extract on hairless mice chronically exposed to UVB radiation (76.5 mJ/cm(2), 4 days per week for 22 weeks). Mouse dorsal surfaces were treated topically with 20 mg/cm(2) of a carbomer 940 gel (vehicle) with or without P. umbellata root extract to a final concentration of 0.1%, for 2 h before irradiation. Another irradiated group received no topical treatment. A fourth group received no treatment and was not irradiated. Visible skin wrinkling was evaluated using a scale ranging from 0 to 4, where 0 corresponds to no skin modification, and 4 to the maximum visual skin alteration observed in our experiments. Histological measurements were carried out on standard haematoxylin & eosin stained sections. The mean distances between the outermost surface of the epidermis (excluding the stratum corneum) and the dermal-epidermal junction were determined by morphometric analysis. These distances were statistically increased in the irradiated control groups when compared to the nonirradiated control group and to the irradiated group using P. umbellata root extract. These data demonstrate that P. umbellata may be successfully used as a topical skin-protecting agent against the deleterious effects of UV radiation.

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“…It contains 4-nerolidylcathecol, an antioxidant compound which protects the cell membrane. Pariparoba is used, over the long term, for digestive problems, liver disease and burns (Moraes, 1986;Ropke et al, 2002Ropke et al, , 2003.…”

Section: Cosmeceuticalsmentioning

confidence: 99%

Ethnopharmacognostic survey on botanical compendia for potential cosmeceutic species from Atlantic Forest

Biavatti¹,

Marensi²,

Leite³

et al. 2007

Rev. bras. farmacogn.

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RESUMO: "Levantamento etnofarmacognóstico em compêndios botânicos de espécies da Mata Atlântica com potencial cosmecêutico". A Mata Atlântica é um dos ecossistemas mais ameaçados do planeta, sendo reconhecida como uma área de grande biodiversidade sob alto nível de stress. A área cosmecêutica abrange medicamentos de uso tópico e cosméticos, e o uso de produtos naturais para aplicação externa sempre foi observado em diversas culturas. Este trabalho trata de uma análise etnofarmacognóstica de dois compêndios botânicos (CB): Dicionário das Plantas Úteis do Brasil -e das exóticas cultivadas, compilado por Pio Correa (PC) e Flora Ilustrada Catarinense (FIC). Destes compêndios, foram selecionadas espécies com uso cosmecêutico ou com características fi sico-químicas e organolépticas relacionadas. Essas espécies selecionadas foram analisadas quanto à validade da nomenclatura botânica e a ocorrência de publicação científi ca, e quanto ao risco de extinção. PC e FIC apontaram que 245 espécies vegetais, pertencendo a 98 famílias, possuem uso cosmecêutico no Brasil. As famílias mais citadas foram: Asteraceae, Fabaceae, Myrtaceae, Annonaceae, Clusiaceae, Anacardiaceae, Apiaceae, Bignoniaceae e Solanaceae. As partes usadas mais citadas foram cascas, folhas e partes aéreas. As propriedades mais citadas foram efeito tônico e adstringente, seguido de efeito cicatrizante, emoliente, antiinfl amatório, antiúlcera, anti-séptico, parasiticida e clareador da pele. De acordo com a pesquisa bibliográfi ca no Pubmed, a maioria das espécies selecionadas (65%) não foi investigada farmacológica e quimicamente.Unitermos: Mata Atlântica, cosmecêuticos, etnobotânica. ABSTRACT:The Atlantic Forest is one of the most endangered ecosystems on earth, and is acknowledged as an area with truly exceptional levels of biodiversity under enormous levels of stress. Cosmeceutics cover a border area between pharmaceuticals for skin diseases and cosmetics. Natural products for external application, to improve the appearance of the skin or for skin treatment, have always been observed and used by native cultures. The present work deals with the ethnopharmacognostic analysis of two botanical compendia (BC), named: Dicionário das Plantas Úteis do Brasil -e das exóticas cultivadas, compiled by Pio Correa (PC) Flora Ilustrada Catarinense (FIC). From these BC, reported species with cosmeceutical uses or with related physico-chemical or organoleptic characteristics were selected, updated, searched for scientifi c background and highlighted if endangered. PC and FIC specifi ed that 245 plant species, belonging to 98 plant families, are used in Brazil for cosmeceutical, cosmetic or skin remedies. The families most widely represented were Asteraceae, Fabaceae, Myrtaceae, Annonaceae, Clusiaceae, Anacardiaceae, Apiaceae, Bignoniaceae and Solanaceae The most frequently cited plant parts were bark, followed by leaves and aerial parts. The most frequently cited properties were astringency and tonic effect followed by uses in skin disorders and wound healing, emollient cha...

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Pothomorphe umbellata Extract Prevents α-Tocopherol Depletion After UV-irradiation

Cited by 13 publications

References 30 publications

In Vivo and In Vitro Antimalarial Activity of 4‐Nerolidylcatechol

In Vivo and In Vitro Antimalarial Activity of 4‐Nerolidylcatechol

Photoprotective effect of Pothomorphe umbellata root extract against ultraviolet radiation induced chronic skin damage in the hairless mouse

Ethnopharmacognostic survey on botanical compendia for potential cosmeceutic species from Atlantic Forest

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