Potentized Mercuric chloride and Nux vomica Facilitate Water Permeability in Erythrocytes of a Fresh-Water Catfish<i>Clarius batrachus</i>Under Acute Ethanol Intoxication

Sukul, Nirmal Chandra; De, Anil K.; Sinhababu, S. P.; Sukul, Anirban

doi:10.1089/107555303322524562

Cited by 10 publications

(13 citation statements)

References 32 publications

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“…We had observed earlier that Nux vomica 30 and Mercury chloride 30 interfered with the transport of water through the plasma membrane of erythrocytes in fresh water cat fish. We proposed that homeopathic potencies acted on water channel proteins of the membrane and produced that effect [9]. After entering the muscle cell, T. spiralis induces significant phenotypic changes in the cell which then re-enter the cell cycle and replicate their DNA [17,18].…”

Section: Discussionmentioning

confidence: 99%

“…An aliquot of chopped muscles of each group of mice was weighed, kept in a BOD incubator at 90 °C for 12 h to remove water and then weighed again. Total water content in the muscles was assessed by measuring the difference between fresh weight and dry weight of the tissues [9,13,14]. The adult worms live in the intestine.…”

Section: Treatmentmentioning

confidence: 99%

“…We further wanted to see whether the homeopathic drugs could alter the water content in the muscles of mice. We previously observed that homeopathic potencies influenced the water permeability of cells [9]. If we are to establish the scientific basis for homeopathy, we have to conduct experiments in a rigorous way including sacrificing animals where it is necessary.…”

Section: Introductionmentioning

confidence: 99%

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Reduction in the Number of Infective Trichinella spiralis Larvae in Mice by Use of Homeopathic Drugs

2005

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Background: Trichinellosis caused by the gastrointestinal nematode Trichinella spiralis occurs in humans, domestic animals and wild animals. It is difficult to control the muscle phase of the parasite. Homeopathic drugs such as Cina and Santoninum have anthelmintic properties. We have observed that in material doses, the homeopathic drug Podophyllum also has nematotoxic properties. We have also observed that homeopathic potency can influence the water permeability of cells. Objective: The purpose of this study was to investigate whether potentized homeopathic drugs such as Cina 30, Santoninum 30 and Podophyllum mother tincture can affect the muscle phase of the parasite T. spiralis in mice. Another objective was to see whether trichinellosis and its treatment with the 3 named homeopathic drugs could alter the water content in the muscle tissue of mice. Materials and Methods: Cina 30 and Santoninum 30 were prepared from the mother tincture of the flowering tops of Artemisia nilagirica and its active principle santonin, in each case by successive dilution (1:100) with 90% ethanol and sonication in 30 steps following the single glass method (K30). Ethanol 30 was prepared by successive dilution of 90% ethanol with 90% ethanol (1:100) followed by sonication in 30 steps. In each step, the dilution was sonicated at 20 KHz for 30 s. We have observed before that sonication is a more uniform, measurable and effective process of mechanical agitation of a liquid than manual succussion. Experimentally infected mice were orally treated with an aqueous Podophyllum suspension at 60 mg/kg/day. Each potentized drug was diluted 1:20 with distilled water and administered orally at 0.05 ml/mouse/day. Each mouse was inoculated with T. spiralis larvae at a dose of 200 larvae/mouse by esophageal intubation. Treatment was started on day 7 post-infection and continued for 120 days. After completion of treatment, the mice were sacrificed and the larvae were extracted from muscles by HCl-pepsin digestion. The water content of the muscles was measured by determining the difference between fresh weight and dry weight of the tissue. Results: Podophyllum ?, Cina 30 and Santoninum 30 reduced the larval population in the studied mice by 68.14%, 84.10% and 81.20%, respectively, as compared to the untreated control group. Ethanol 30 achieved no significant reduction in the larval population compared to the untreated control group. The water content of the muscle tissue in the untreated control group and the Podophyllum-treated groups was significantly higher than in the Ethanol 30-, Cina 30- and Santoninum 30-treated groups. Conclusions: (1) Podophyllum ?, Cina 30 and Santoninum 30 were effective in the muscle phase of T. spiralis infection and significantly reduced the larval population in the treated mice. The potencies were more effective than the mother tincture, an effect which was not due to the medium ethanol. (2) The potencies significantly reduced the water content of the muscle tissue which might have affected the larvae. The effect of Po...

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Section: Discussionmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Reduction in the Number of Infective Trichinella spiralis Larvae in Mice by Use of Homeopathic Drugs

2005

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“…Extracts of strychnous nux-vomica has been found to reduce voluntary alcohol intake in rats [17]. A possible proposed mechanism of action is that the drug interacts with membrane aquaporins facilitating water influx into cells [18].…”

Section: Whole Medical Systemsmentioning

confidence: 99%

“…Studies on biological markers of alcoholism have found alcoholics and sons of alcoholics to have EEG wave patterns in the fast alpha (9-12 Hz) and beta (12)(13)(14)(15)(16)(17)(18)(19)(20) Hz) range [81][82][83]. Biofeedback aims at the patient learning to convert her/his brain wave activity from the alpha to theta range.…”

Section: Electroencephalogram Biofeedbackmentioning

confidence: 99%

Complementary and alternative medicine in the treatment of substance use disorders—a review of the evidence

Behere¹,

Muralidharan²,

Benegal³

2009

Drug and Alcohol Review

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Aquaporins as targets of pharmacological plant-derived compounds

2013

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Potentized Mercuric chloride and Nux vomica Facilitate Water Permeability in Erythrocytes of a Fresh-Water CatfishClarius batrachusUnder Acute Ethanol Intoxication

Abstract: Because water channel proteins or aquaporins are mainly responsible for water transport through the plasma membrane of RBCs, it is thought that potentized drugs interact with these proteins, thereby facilitating water influx in the cells.

Cited by 10 publications

References 32 publications

Reduction in the Number of Infective Trichinella spiralis Larvae in Mice by Use of Homeopathic Drugs

Reduction in the Number of Infective Trichinella spiralis Larvae in Mice by Use of Homeopathic Drugs

Complementary and alternative medicine in the treatment of substance use disorders—a review of the evidence

Aquaporins as targets of pharmacological plant-derived compounds

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