Potentiometric, spectrophotometric and calorimetric study on iron(III) and copper(II) complexes with 1,2-dimethyl-3-hydroxy-4-pyridinone

Deferiprone, a non-toxic reagent for determination of iron in samples via sequential injection analysis

“…Fig. 3 showed a break in the slope of the curve that occurred at the mole-ratio (Fe(III) : deferiprone) of 1:3 which was in accordance to the previous study [2]. Fig.…”

“…Above of this pH, the absorbance was decreased significantly. It can be explained that, pH 7.5 was increased the ionic strength of the solution and stabilized the anionic forms of deferiprone resulting to form the Fe(III)-deferiprone complex efficiently [2]. Thus the maximum absorption wavelength of the complex at 460 nm at pH 7.5 was used for further studies.…”

“…1b). This complex is stable in an aqueous solution with the maximum absorption wavelength at 450 nm [1,2,3].…”

3-Hidroksipiridin-4-oni (I. dio): Priprava i kelirajući učinak

“…Primjerice, kod obaju protoniranih oblika deferiprona iznosi energija za protoniranje dušikova i kisikova atoma jasno se razlikuju i iznose redom + 69,9 kcal mol . 34 Kao što se može vidjeti iz sheme 7, vrijednosti pK a piridinonskog skeleta su za većinu N-alkilnih i N-arilnih 3,4-HP derivata vrlo slične bez obzira na vrstu supstituenta na dušikovu atomu. Drugim riječima, varijacijom supstituenta može se podešavati lipo-hidrofilni karakter, opisan već spomenutim parametrom log P, a pritom ne utjecati značajno na kiselo-bazna svojstva 3,4-HP prstena.…”

Iron Chelating Agents for Iron Overload Diseases

“…In particular, examining the protonation and the stability constants of pyridinones, reported in Table 1, [23][24][25][26] good linear correlations are found between the first protonation constant and the formation constants log K 11 , log K 12 and log K 13 relative to FeL, FeL 2 and FeL 3 complexes respectively, as well as with the second protonation constant log K 2 ( Figure 2A).…”