Deferiprone, a non-toxic reagent for determination of iron in samples via sequential injection analysis

Pragourpun, Kraivinee; Sakee, Uthai; Fernandez, Carlos; Kruanetr, Senee

doi:10.1016/j.saa.2015.01.081

Cited by 23 publications

(9 citation statements)

References 21 publications

(14 reference statements)

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“…In addition to the Fe doping to tune the biodegradability, the well‐defined hollow mesoporous structure is well‐preserved for chemotherapeutic drug doxorubicin (DOX) encapsulation to form the functioning nanoparticles DOX@PEG/Fe‐HMSNs ( Figure a). This design is based on the principle that iron ions can be quickly coordinated by Fe‐coordination proteins/agents such as transferrin, desferrioxamine, and deferiprone, which has been previously used for the development of drugs to treat Fe overdose related diseases . Importantly, the Fe ion coordination with proteins and subsequent removal would leave the silica framework with abundant “defects” and reactive sites, which would further accelerate the biodegradation of silica framework .…”

mentioning

confidence: 99%

Coordination‐Accelerated “Iron Extraction” Enables Fast Biodegradation of Mesoporous Silica‐Based Hollow Nanoparticles

Wang

Huo

Chen

et al. 2017

Adv Healthcare Materials

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Biodegradation behavior of inorganic silica-based nanoplatforms is of critical importance in their clinical translations, but still remains a great challenge in achieving this goal by composition regulation of biocompatible silica framework. In the present work, a chemical coordination-accelerated biodegradation strategy to endow hollow mesoporous silica nanoparticles (HMSNs) with unique coordination-responsive biodegradability, on-demand coordination-responsive drug releasing behavior, and significantly enhanced chemotherapeutic efficacy by directly doping iron (Fe) ions into the framework of mesoporous silica is reported. A simple but versatile dissolution-regrowth strategy has been developed to enable the framework Fe doping via chemical bonding. The deferiprone-mediated biodegradation of Fe-doped HMSNs (Fe-HMSNs) has been comprehensively evaluated both in simulated body fluid and intracellular level, which have exhibited a specific coordination-accelerated biodegradation behavior. In addition to high biocompatibility of Fe-HMSNs, the anticancer drug doxorubicin (DOX)-loaded Fe-HMSNs show enhanced tumor-suppressing effect on 4T1 mammary cancer xenograft. This work paves a new way for tuning the biodegradation performance of mesoporous silica-based nanoplatforms simply by biocompatible Fe-ion doping into silica framework based on the specific coordination property between introduced metal Fe ions with Fe-coordination proteins.

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confidence: 99%

Coordination‐Accelerated “Iron Extraction” Enables Fast Biodegradation of Mesoporous Silica‐Based Hollow Nanoparticles

Wang

Huo

Chen

et al. 2017

Adv Healthcare Materials

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“…Our obtained results were compared with the recommended literature values given in Table 4. A statistical tool (Student's t-test) was employed to evaluate whether the online flow-based procedure yielded reliable results (Pragourpun et al 2015), and the null hypotheses (H 0 ) were used. Student's t-test with multiple sample means (paired by difference) was applied to examine whether the two results differ significantly at 95% confidence level (Mulaudzi and van Staden 2002).…”

Section: Serial Numbermentioning

confidence: 99%

Online Flow‐Based Spectrophotometric Determination of Ferrous Iron Mass Fraction and Total Iron Mass Fraction in Twenty‐Seven Rock Reference Materials Using a Schlenk line Technique

Xue

Liu

et al. 2020

Geostandard Geoanalytic Res

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We developed an online continuous-flow spectrophotometric method for determination of ferrous iron and total iron mass fractions in various types of geological certified reference materials (CRMs) using a Schlenk line technique to exclude oxygen during the digestion process. The continuous-flow technique enabled automatic, reliable and real-time analysis, and decreased sample and reagent consumption. The Schlenk line expels air to prevent oxidation during sample digestion. Compared with traditional spectrophotometric procedures, this analytical procedure is easier, more automated and more accurate. The composition of the acid matrix and time used to dissolve the samples were carefully examined. The procedure was tested on 186 replicates of twenty-seven rock CRMs, and the results showed good agreement with the compiled values from the literature. Based on the statistical data, the proposed procedure was found to be accurate within 0.12% m/m for ferrous iron mass fraction and 0.084% m/m for total iron mass fraction compared with the certified/ recommended values. The proposed procedure is accurate, reproducible and has a high throughput (ten samples per hour).

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“…6,[8][9][10][11][12]14,16 Most of the techniques reported in the literature are based on ow injection analysis (FIA) with UV-visible detection including simple FIA, 8,9,11 reversed FIA, 6,7 and sequential injection FIA. 15 However, the FIA technique is complicated because it requires many components for setting up the system. Moreover, it needs a UV-visible spectrophotometer to connect as a detector which is a cost-effective instrument.…”

Section: Introductionmentioning

confidence: 99%

Smartphone-based digital image colorimetry for determination of iron in cereals and crispy seaweed using Terminalia chebula retz. extract as a natural reagent

et al. 2022

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Deferiprone, a non-toxic reagent for determination of iron in samples via sequential injection analysis

Cited by 23 publications

References 21 publications

Coordination‐Accelerated “Iron Extraction” Enables Fast Biodegradation of Mesoporous Silica‐Based Hollow Nanoparticles

Coordination‐Accelerated “Iron Extraction” Enables Fast Biodegradation of Mesoporous Silica‐Based Hollow Nanoparticles

Online Flow‐Based Spectrophotometric Determination of Ferrous Iron Mass Fraction and Total Iron Mass Fraction in Twenty‐Seven Rock Reference Materials Using a Schlenk line Technique

Smartphone-based digital image colorimetry for determination of iron in cereals and crispy seaweed using Terminalia chebula retz. extract as a natural reagent

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