Potentiometric Sensor for the Determination of Dibucaine in Pharmaceutical Preparations and Electrochemical Study of the Drug with BSA

Abstract

Plasticized poly(vinyl chloride), PVCs, with different membrane compositions tested for use in the construction of an ion-selective sensor for the determination dibucaine. A prepared membrane with dioctyl phthalate-PVC and ion-pair of N-(1-naphthyl)ethylenediamine dihydrochloride-tetraphenyl borate had a good potential to acts as a potentiometric sensor for the analysis of dibucaine. A linear relationship was obtained between potential and logC varying between 1.0 × 10 −6 and 1.0 × 10 −2 M dibucaine with a good repeatability and reproducibility. The sensor was applied for the determination of the drug in pharmaceuticals and biological fluids such as plasma and urine samples with satisfactory results. The drug electrode has also been used to study the interaction of bovine serum albumin (BSA) with dibucaine. The saturated quantities of dibucaine binding were 13.04, 5.30 and 9.70 mol/mol in 0.01, 0.02 and 0.1% of protein, respectively.

Electrochemical Detection of a Local Anesthetic Dibucaine at Arrays of Liquid|Liquid MicroInterfaces

“…A graphite pencil|Britton-Robinson buffer DPV SWV 1.5-18 1-11 0.7 ± 0.05 0.5 ± 0.06 [21] An activated glassy carbon|Britton-Robinson buffer DPV SWV 1.3-14 2-28 0.4 ± 0.002 0.9 ± 0.003 [21] Silver nanoparticle on glassy carbon electrode DPV 18.5-72.2 0.002 [22] An ion-selective electrode Potentiometric 1-10 0.7 [54] In situ carbon paste electrodes Potentiometric 10-10,000 10 ± 0.14 [55] Water|1,6-DCH DPV 4-24 0.9 ± 0.06 This work…”

Multivariate calibration method for Simultaneous estimation of Fluocortolone caproate, Fluocortolone pivalate and Cinchocaine HCl in suppository

“…There are a few studies in the literature describing the determination of fluocortolone and its esters FCC and FCP using thin layer chromatography 122 [3] (TLC), high performance liquid chromatography [4][5] (HPLC), raman spectroscopy [6][7], and spectrophotometry [8]. Unlike fluocortolone, many studies including the use of spectrophotometry [2,9], fluorimetry [10], TLC [11], liquid chromatography-mass spectrometry [12], sequential injection chromatography [13], HPLC [2,[14][15][16], gas chromatography [17], chemometry [18] and electroanalytical methods [19][20][21] have been used for the determination of CIN. A HPLC method has been reported for the simultaneous determination of the three drugs [22].…”

Experimental Design Approach in the Optimization of Potentiometric Method for Lansoprazole Determination Using Lansoprazole-Tungstate Based Ion-Selective Electrode

“…Recently, the applications of membrane ion-selective electrodes have been extended for assay of drugs pharmaceutical formulations and biological samples due to good selectivity and accuracy with wide linear dynamic range. 33 The ion-pair complexes have been used as ionophores for fabrication of PVC membrane based ion-selective electrode. Phosphotungstate, 34−36 tetra phenyl borate, 37,38 phosphomolybdate, 36 tungstophosphate, 39 tetrakis (4-chlorophenyl) borate, 40 silicotungstate 41 were used as counterions in the fabrication of PVC based ion-selective membranes.…”

“…Recently, the applications of membrane ion-selective electrodes have been extended for assay of drugs pharmaceutical formulations and biological samples due to good selectivity and accuracy with wide linear dynamic range . The ion-pair complexes have been used as ionophores for fabrication of PVC membrane based ion-selective electrode.…”