Potentiometric sensor fabrication having 2D sarcosine memories and analytical features

Özkütük, Ebru Birlik; Di̇ltemi̇z, Sibel Emi̇r; Avcı, Şeyma; Uğurağ, Deniz; Aykanat, Rabia Berna; Ersöz, Arzu; Say, Rıdvan

doi:10.1016/j.msec.2016.06.057

Cited by 21 publications

(1 citation statement)

References 40 publications

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“…One of the most important classes of electrochemical sensors is potentiometric sensors that transduce the activity of a certain dissolved analyte into an electrical potential. However, only a few potentiometric sensors based on molecularly imprinted polymers or sarcosine antibody were reported for sarcosine determination [ 18 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

Point-of-care diagnostics for rapid determination of prostate cancer biomarker sarcosine: application of disposable potentiometric sensor based on oxide-conductive polymer nanocomposite

et al. 2023

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One of the most important reasons for an increased mortality rate of cancer is late diagnosis. Point-of-care (POC) diagnostic sensors can provide rapid and cost-effective diagnosis and monitoring of cancer biomarkers. Portable, disposable, and sensitive sarcosine solid-contact ion-selective potentiometric sensors (SC-ISEs) were fabricated as POC analyzers for the rapid determination of the prostate cancer biomarker sarcosine. Tungsten trioxide nanoparticles (WO3 NPs), polyaniline nanoparticles (PANI NPs), and PANI-WO3 nanocomposite were used as ion-to-electron transducers on screen-printed sensors. WO3 NPs and PANI-WO3 nanocomposite have not been investigated before as ion-to-electron transducer layers in potentiometric SC sensors. The designated sensors were characterized using SEM, XRD, FTIR, UV-VIS spectroscopy, and EIS. The inclusion of WO3 and PANI in SC sensors enhanced the transduction at the interface between the screen-printed SC and the ion-selective membrane, offering lower potential drift, a longer lifetime, shorter response time, and better sensitivity. The proposed sarcosine sensors exhibited Nernstian slopes over linear response ranges 10−3–10−7 M, 10−3–10−8 M, 10−5–10−9 M, and 10−7–10−12 M for control, WO3 NPs, PANI NPs, and PANI-WO3 nanocomposite-based sensors, respectively. From a comparative point of view between the four sensors, PANI-WO3 nanocomposite inclusion offered the lowest potential drift (0.5 mV h−1), the longest lifetime (4 months), and the best LOD (9.95 × 10−13 M). The proposed sensors were successfully applied to determine sarcosine as a potential prostate cancer biomarker in urine without prior sample treatment steps. The WHO ASSURED criteria for point-of-care diagnostics are met by the proposed sensors. Graphical abstract

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Section: Introductionmentioning

confidence: 99%