“…Lamotrigine (LMT) (3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine [1], (Scheme 1) under the Lamictal brand is one of the most novel antiepileptic drugs (AEDs), which is effectively used for the remedy of epilepsy, bipolar disorder, and acute episodes of depression [2,3]. LMT, like the other antiepilepsy drugs, acts on voltage-dependent sodium and calcium channels, thereby preventing the release of amino acids such as glutamate and aspartate, which have a critical role in epileptic seizures [2].…”