Potentiometric Sensing of Lamotrigine Based on Molecularly Imprinted Polymers

Sadeghi, Hayedeh Bagheri; Ebrahimi, Soltan Ahmad; Tamaddon, Atefeh; Bozorgvar, Fatemeh; Afifinia, Hadi; Almasian, Nasim; Mollaei, Somayeh

doi:10.1002/elan.201100140

Cited by 19 publications

(7 citation statements)

References 45 publications

(35 reference statements)

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“…The optimal amounts of the plasticizer TEHP and PVC were determined in preliminary experiments, based on improved membrane mobility and decreased membrane resistance. Because lipophilic salts or ionic additives can reduce ion interference and improve selectivity of electrode (Sadeghi et al, 2011), NaTPB was incorporated in the membrane and the sensor without NaTPB was also prepared for reference. Although the additive was retained in the following sensors, there was no significant improvement found in the potential response or selectivity of sensor compared to the sensor without NaTPB by two-way ANOVA (P > 0.05), according to the omissive comparative measurement in the following section "Calibration curve" and "Sensor selectivity."…”

Section: Optimization Of Electrode Membranementioning

confidence: 99%

Facile potentiometric sensing of gallic acid in edible plants based on molecularly imprinted polymer

Yang

Zhang

Chen

et al. 2020

Journal of Food Science

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Molecularly imprinted polymers (MIPs) have become a valuable material in the field of electrochemical sensors, due to their selective recognition capabilities towards target molecules. A low‐cost potentiometric sensor based on molecular imprinting was developed for the measurement of gallic acid (GA) in edible plants. The imprinted polymer was synthesized by bulk polymerization in the presence of trimethylolpropane triacrylate as the cross‐linker and 2,2’‐azo‐bisisobutyronitrile as the initiator. The sensing component of the sensor was fabricated by the incorporation of MIPs in a polyvinyl chloride matrix. The species and amount of MIPs were optimized, and the imprinted poly(methacrylic acid) sensor was examined and characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and potential response. The proposed sensor exhibited a fast near‐Nernst response to GA in the range of 1 × 10−5 to 3.2 × 10−4mol/L. The potentiometric measurement of GA in edible plants was checked by high‐performance liquid chromatography, and the two test results showed no significant difference (P > 0.05). The imprinted sensor is applicable to the electrochemical determination of GA in edible plants. Practical Application The proposed MIP‐based potentiometric sensor provided a low‐cost, efficient, and green tool for the rapid determination of the bioactive ingredient GA in edible plants. The knowledge obtained will offer useful reference to the quality control and bioactive assessment of botanical food.

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Section: Optimization Of Electrode Membranementioning

confidence: 99%

Facile potentiometric sensing of gallic acid in edible plants based on molecularly imprinted polymer

Yang

Zhang

Chen

et al. 2020

Journal of Food Science

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“…Enrofloxacin, an antibacterial against both gram positive and gram negative bacteria was measured using o‐NPOE (o‐nitrophenyl octyl ether) plasticizer with an MIP, again in a PVC matrix [121]; this gave a slope of 56.8 mV/decade. For the antiepileptic lamotrigine [101], MAA with EGDMA generated an effective MIP in combination with dioctyl phthalate plasticizer and TPB, and though slope was low (30.8 mV/decade), LoD 8×10 −7 M was obtained. The Alzheimer's drug, mematine hydrochloride [95] was measured with a particulate MIP and dibutyl sebacate combination.…”

Section: Mip Based Potentiometric Sensorsmentioning

confidence: 99%

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Feroz

Vadgama

2020

Electroanalysis

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Molecular imprinted polymers (MIPs) are tailor made from synthetic polymers and designed to mimic the recognition properties of natural biological affinity molecules. MIPs incorporate binding motifs complementary to target organic molecule shape and functional groups in order to mimic the complex binding surfaces of natural macromolecules. This confers selectivity and specificity, with the added advantage of artificial MIP polymer stability and ready adaptability to the fabrication and creation of miniaturised affinity interfaces for electrochemical sensing and extra‐laboratory testing. Their generic capability as robust sorbent phases for drug extraction and concentration allows for targeted, interfacial interrogation by the active electrochemical surface. A wide range of electrochemical sensing strategies has also been advanced in recent years, which is covered by this review. The review covers MIP functional principles, examples of MIP preparative routes and final assay outcomes for the measurement of small molecule drugs of biomedical, and also of potential environmental relevance. Some small molecules as examples of toxin and contaminant measurement are also given. A historic background to MIP development is provided, but the review mainly focuses on electrochemical sensor advances in the last five years.

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“…Lamotrigine (LMT) (3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine [1], (Scheme 1) under the Lamictal brand is one of the most novel antiepileptic drugs (AEDs), which is effectively used for the remedy of epilepsy, bipolar disorder, and acute episodes of depression [2,3]. LMT, like the other antiepilepsy drugs, acts on voltage-dependent sodium and calcium channels, thereby preventing the release of amino acids such as glutamate and aspartate, which have a critical role in epileptic seizures [2].…”

Section: Introductionmentioning

confidence: 99%

“…Luminophores as one of the most significant components during the light generation processes in ECL can be immobilized at the surface electrode or dissolved in the electrolyte solution. Until now, various compounds such as Si nanocrystals, Ru(bpy) 3 2 + , CdTe, CdSe [21], Ag 2 S [22], luminol [23], iridium complexes, ZnSe, and carbon quantum dots [24] were commonly utilized as ECL luminophore.…”

Section: Introductionmentioning

confidence: 99%

A Novel Electrochemiluminesence Sensor Based on Silver Prussian Blue Analogue/Carboxylated Sulfur‐doped Graphitic Carbon Nitride Nanocomposite for Determination of Lamotrigine

2022

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In this study, for the first time an electrochemiluminescence sensor for ultra-trace monitoring of lamotrigine is reported. The sensing probe was fabricated using silver prussian blue analogue as a new effective coreaction accelerator and carboxylated sulfur-doped graphitic carbon nitride nanocomposite as a new green luminophore. Also potassium peroxydisulfate was utilized as a strong co-reactant. The proposed ECL sensor exhibited excellent wide linear range (3.45 × 10 À 15 to 2.98 × 10 À 8 M), low detection limit (4.89 × 10 À 16 M), the relative standard deviation of 1.07 %, outstanding reproducibility and superior long-term stability. The prominent advantages of the sensor showed that it can be used to determine LMT in clinical samples.

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Potentiometric Sensing of Lamotrigine Based on Molecularly Imprinted Polymers

Cited by 19 publications

References 45 publications

Facile potentiometric sensing of gallic acid in edible plants based on molecularly imprinted polymer

Facile potentiometric sensing of gallic acid in edible plants based on molecularly imprinted polymer

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

A Novel Electrochemiluminesence Sensor Based on Silver Prussian Blue Analogue/Carboxylated Sulfur‐doped Graphitic Carbon Nitride Nanocomposite for Determination of Lamotrigine

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