Potentiometric membrane sensors for the selective determination of cinnarizine in pharmaceutical preparations

Hassan, Saad S. M.; Abdel-Aziz, Ragab M.; Abbas, Alaa B.

doi:10.1016/0003-2670(95)00515-3

Cited by 23 publications

(8 citation statements)

References 12 publications

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“…The separate solution method 18,19) with aˆxed concentration of the interferent (10 -3 M) was used for evaluation of the selectivity. The results obtained by the developed sensors, Table 2, showed reasonable selectivity for the two sensors for tiapride hydrochloride in presence of any of the mentioned interferent.…”

Section: Resultsmentioning

confidence: 99%

Membrane Sensors for the Selective Determination of Tiapride in Presence of its Degradation Products

Metwally

2007

YAKUGAKU ZASSHI

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The construction and electrochemical response characteristics of polyvinyl chloride (PVC) membrane sensors for determination of tiapride in presence of its degradation products are described. The sensors are based on the ion association complexes of tiapride cation with sodium tetraphenyl borate (Tia-TPB) [sensor 1]) or ammonium reineckate (Tia-R) [sensor 2] counter anions as ion exchange sites in PVC matrix. The performance characteristics, sensitivity and selectivity of these electrodes in presence of tiapride degradation products were evaluated according to IUPAC recommendations. It reveals a fast, stable and linear response for tiapride over the concentration range 10 -5  10 -2 M with cationic slopes of 28.997 and 30.580 mV per concentration decade with sensors 1 and 2, respectively. These sensors exhibit fast response time (20 30 s), low quantitation limit (4.5×10 -6 and 3.6×10 -6 , respectively), and good stability (6 8 weeks). The direct potentiometric determination of tiapride hydrochloride using the proposed sensors gave average recoveries of 99.95±0.678 and 99.92±1.157 for sensors 1 and 2, respectively. The sensors are used for determination of tiapride hydrochloride, in pure form, in presence of its degradation products in tablets, and in plasma. Validation of the method shows suitability of the proposed sensors for use in the quality control assessment of tiapride hydrochloride and for routine analysis as stability indicating method. The developed method was found to be simple, accurate and precise when compared with a reference company spectrophotometric method.

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Section: Resultsmentioning

confidence: 99%

Membrane Sensors for the Selective Determination of Tiapride in Presence of its Degradation Products

Metwally

2007

YAKUGAKU ZASSHI

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“…[8][9][10] It has been used in the formation of many sensors. [11][12][13] In this work, it has been found that RIV reacts with (TpClPB) to form water insoluble ion association complexes. The high lipophilicity and remarkable stability of these complexes suggested their selective use as electroactive materials in PVC matrix membrane sensors for the determination of the drug studied, in the presence of its degradation product and related substances.…”

mentioning

confidence: 89%

Miniaturized Membrane Sensors for the Determination of Rivastigmine Hydrogen Tartrate

El-Kosasy

Salem

El-Bardicy

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Alternatively, several methods have been described in the literature for the determination of CNZ in its pharmaceutical dosage forms or in biological samples. Examples of these methods are various spectrophotometric and/or chemometric spectrophotometric methods (El-Gindy et al, 2004;Metwally et al, 2005;Gazy et al, 2006;El-Bardicy et al, 2008;Abdelrahman, 2013), synchronous fluorescence spectroscopy , chemiluminescence using flow-injection analysis (Townshend et al, 2003), voltammetry Hegde et al, 2009), potentiometric membrane sensors (Hassan et al, 1996), HPLC with UV detection (El-Gindy et al, 2004;Metwally et al, 2005;Heda et al, 2010;Navaneethan et al, 2013), HPLC with fluorescence detection (Angelov and Christova-Bagdassarian, 2003;Nowacka-Krukowska et al, 2007) and capillary electrophoresis . Few articles reported the HPTLC determination of pharmaceutical mixtures containing CNZ with piracetam (Metwally et al, 2005) and domperidone (Argekar and Powar, 1999;Bagade et al, 2005;Vinodhini et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Validated HPTLC method for the simultaneous determination of cinnarizine and dimenhydrinate in their combined dosage form

El-Kafrawy

Belal

2016

Journal of the Association of Arab Universities for Basic and A

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A simple, rapid and selective high performance thin layer chromatography (HPTLC) method was developed for the simultaneous determination of cinnarizine (CNZ) and dimenhydrinate (DMH) in pure form and in their combined dosage form. Reviewing the literature revealed that there are no reports for the use of TLC for the assay of this mixture. Effective separation was achieved using Fluka HPTLC aluminum sheets of silica gel 60 F 254 using chloroform-n-hexanemethanol (8.5:0.8:0.7, by volume) as mobile phase, followed by densitometric measurement of CNZ and DMH spots at 254 and 279 nm, respectively. The reliability and analytical performance of the proposed HPTLC method were statistically validated with respect to linearity, ranges, precision, accuracy, selectivity, robustness and detection and quantification limits. Calibration curves were linear in the ranges of 50-400 and 50-500 ng/spot for CNZ and DMH, respectively with correlation coefficients >0.9998. The limits of detection were 8.1 and 8.0 ng/spot for CNZ and DMH respectively. The validated HPTLC method was applied to the simultaneous analysis of CNZ and DMH in laboratory-prepared tablets. Both analytes were successfully quantified with good recovery values, and no interference was encountered from the inactive ingredients. ª 2014 Production and hosting by Elsevier B.V. on behalf of University of Bahrain.

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Potentiometric membrane sensors for the selective determination of cinnarizine in pharmaceutical preparations

Cited by 23 publications

References 12 publications

Membrane Sensors for the Selective Determination of Tiapride in Presence of its Degradation Products

Membrane Sensors for the Selective Determination of Tiapride in Presence of its Degradation Products

Miniaturized Membrane Sensors for the Determination of Rivastigmine Hydrogen Tartrate

Validated HPTLC method for the simultaneous determination of cinnarizine and dimenhydrinate in their combined dosage form

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