Potentiometric Determination of Imatinib under Batch and Flow Injection Analysis Conditions

Karim, Shereen E. Abdel; El‐Nashar, Rasha M.; Abadi, Ashraf H.

doi:10.1016/s1452-3981(23)16228-6

Cited by 8 publications

(1 citation statement)

References 36 publications

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“…According to previous reports, monitoring IMB levels in real biological samples is of great environmental and clinical importance [6,7]. Various analyses, such as capillary electrophoresis, high-performance liquid chromatography, gas chromatography, Biosensors 2023, 13, 547 2 of 14 and fluorescence spectroscopy, have been used to measure the concentration of IMAT [8][9][10][11][12][13]. Most of these methods, despite their high sensitivity and highly accurate measurements, are associated with limitations, such as high operating costs, long analysis responses, complex instrumentation, and the need for a large number of samples and skilled and capable operators.…”

Section: Introductionmentioning

confidence: 99%

A Modified Electrochemical Sensor Based on N,S-Doped Carbon Dots/Carbon Nanotube-Poly(Amidoamine) Dendrimer Hybrids for Imatinib Mesylate Determination

et al. 2023

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Imatinib mesylate, an anticancer drug, is prescribed to treat gastrointestinal stromal tumors and chronic myelogenous leukemia. A hybrid nanocomposite of N,S-doped carbon dots/carbon nanotube-poly(amidoamine) dendrimer (N,S-CDs/CNTD) was successfully synthesized and used as a significant modifier to design a new and highly selective electrochemical sensor for the determination of imatinib mesylate. A rigorous study with electrochemical techniques, such as cyclic voltammetry and differential pulse voltammetry, was performed to elucidate the electrocatalytic properties of the as-prepared nanocomposite and the preparation procedure of the modified glassy carbon electrode (GCE). A higher oxidation peak current was generated for the imatinib mesylate on a N,S-CDs/CNTD/GCE surface compared to the GCE and CNTD/GCE. The N,S-CDs/CNTD/GCE showed a linear relationship between the concentration and oxidation peak current of the imatinib mesylate in 0.01–100 μM, with a detection limit of 3 nM. Finally, the imatinib mesylate’s quantification in blood-serum samples was successfully performed. The N,S-CDs/CNTD/GCE’s reproducibility and stability were indeed excellent.

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