Potentiometric and pHmetric Studies of Paracetamol

Paracetamol (acetaminophen) is a widely used over-the-counter analgesic, antipyretic and a mild anti inflammatory drug. In several developing countries some of pharmaceutical industries sale fake, counterfeit and substandard drugs which affect the health of people. The present study investigates the comparison for the quantitative determination of various brands of paracetamol tablet using UV-Visible spectrophotometric, potentiometric and trimetric methods. Four brands (Pacimol, Paracip, Parazest, and Crocin) of paracetamol tablets having 500 mg strength were purchased from various pharmacy shops within Pari chowk and Jagat market in Greater Noida, India. Weight variation test was performed before the assay of paracetamol samples. The result of tablets weight variation (Mean ± S.D) of Crocin, Parazest, Paracip and Pacimol brand was 0.66 ± 0.014, 0.64 ± 0.010, 0.58 ± 0.007 and 0.55 ± 0.009 respectively. All brands showed different mean weight which indicates the use of different excipients in the different brands. The ranges of the amount of paracetamol content (g/tab) for paracetamol samples analyzed using UV-Visible spectrophotometric, potentiometric and trimetric methods were from 0.49195-0.52010, 0.48300-0.52100 and 0.48106-0.50110 respectively. The results indicated that all four brands of paracetamol tablets have sufficient quantity and amount is approximately similar to the company’s recommended or claimed value. Similarly, the ranges of percentage content (assay) of the analyzed samples using UV-Visible spectrophotometric, potentiometric and trimetric methods were from 98.69-104.20%, 96.60-104.20%, and 96.21-100.22% respectively. The assay results indicated that variation among all brands and this may show that different manufacturer formulates the different brands are under the IP specification. However, all of the brands of the tablets under the study were complied with the IP specification and passed for weight variation test and assay conducted on it. Hence, the drug control authority of the government should be continuously monitored the safety, quality, and efficacy of paracetamol tablet through post marketing surveillance practices, and the proper internal quality control of the pharmaceutical companies need to take further necessary steps to ensure the continuity in the establishment of the product quantity and quality. Keywords: Assay, Brands, Comparative, Determination, Paracetamol, Tablets

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“…The potentiometric measurement is performed at room temperature (25°C). The titration procedures performed following Gupta SNR method 23 .…”

Section: Potentiometric Assay Methodmentioning

confidence: 99%

A Comparative Study for the Quantitative Determination of Different Brands of Paracetamol Tablet Using Uv-Visible Spectrophotometric, Potentiometric and Trimetric Methods.

Tilki

Singh

Arya

2019

JBPR

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“…A numerous analytical methods have been reported for paracetamol determination in pharmaceutical formulations. These methods include, potentiometry [3][4][5][6][7], high performance liquid chromatography [8][9][10][11][12][13], and spectrophotometry [14] . These reported methods have some limitations such as instruments, skills, cost, and the environment.…”

mentioning

confidence: 99%

Voltammetric Determination of Paracetamol in Pharmaceutical Formulations at Iodine-Coated Polycrystalline Platinum Electrode

Amayreh

Hourani²,

Hourani

2021

MOCA

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In this work the modified iodine-coated polycrystalline platinum electrode was used to develope a voltammetric sensor for paracetamol determination in pharmaceutical formulations. The optimized experimental parameters for the determination of paracetamol were using 0.5 M H2SO4 as a supporting electrolyte with a scan rate of 50 mV/s. The anodic peak related to paracetamol oxidation was centered at about +0.60 V. The extended calibration graph was constructed between 1 ppm and 500 ppm. The anodic current showed excellent linearity with R2 = 0.9985. The limit of detection (LOD) and limit of quantitation (LOQ) were 0.046 and 0.139 ppm, respectively, which attests to the sensitivity of the method. The investigation for the effect of potential interferences from the content of tablet matrices indicated a specific selectivity toward paracetamol and the absence of any electrochemical response toward these components. The developed method was successfully applied to analysis paracetamol in three brands of pharmaceutical formulations and the obtained results were in good agreement with the labeled values, besides that, the statistical tests indicated no significant difference at p = 0.05 with a 95 % confidence level.

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Potentiometric and pHmetric Studies of Paracetamol

Cited by 2 publications

References 9 publications

A Comparative Study for the Quantitative Determination of Different Brands of Paracetamol Tablet Using Uv-Visible Spectrophotometric, Potentiometric and Trimetric Methods.

A Comparative Study for the Quantitative Determination of Different Brands of Paracetamol Tablet Using Uv-Visible Spectrophotometric, Potentiometric and Trimetric Methods.

Voltammetric Determination of Paracetamol in Pharmaceutical Formulations at Iodine-Coated Polycrystalline Platinum Electrode

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