Potentilla and Rubus medicinal plants

Hao, Da‐Cheng; Gu, Xiao-Jie; Xiao, Pei

doi:10.1016/b978-0-08-100085-4.00010-4

Cited by 13 publications

(21 citation statements)

References 129 publications

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“…LC-MS analysis revealed the presence of numerous metabolites that were reported to have antimicrobial [ 38 , 39 ], anti-diabetic [ 40 ], anti-haemolytic [ 41 ], anti-inflammatory [ 42 , 43 ], anti-obesity [ 44 ], and cytotoxic activities [ 45 ] in both fungi. GC-MS analysis also proved effective in recovering already characterized VOCs with antimicrobial [ 46 ], anti-haemolytic [ 42 ], anti-inflammatory [ 47 ], anti-obesity [ 48 ] and cytotoxic activities [ 49 ]. In addition to these metabolites that could partially account for the fungal extracts’ biological activities, LC-MS and GC-MS analyses also confirmed the presence of numerous other compounds that have never been reported to possess any of these tested activities.…”

Section: Discussionmentioning

confidence: 99%

Date Palm Trees Root-Derived Endophytes as Fungal Cell Factories for Diverse Bioactive Metabolites

Mefteh

Daoud

Bouket

et al. 2018

IJMS

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Endophytic fungi of healthy and brittle leaf diseased (BLD) date palm trees (Phoenix dactylifera L.) represent a promising source of bioactive compounds with biomedical, industrial, and pharmaceutical applications. The fungal endophytes Penicillium citrinum isolate TDPEF34, and Geotrichum candidum isolate TDPEF20 from healthy and BLD date palm trees, respectively, proved very effective in confrontation assays against three pathogenic bacteria, including two Gram-positive bacteria Bacillus thuringiensis (Bt) and Enterococcus faecalis (Ef), and one Gram-negative bacterium Salmonella enterica (St). They also inhibited the growth of three fungi Trichoderma sp. (Ti), Fusarium sporotrichioides (Fs), Trichoderma sp. (Ts). Additionally, their volatile organic compounds (VOCs) were shown to be in part responsible for the inhibition of Ti and Ts and could account for the full inhibition of Fs. Therefore, we have explored their potential as fungal cell factories for bioactive metabolites production. Four extracts of each endophyte were prepared using different solvent polarities, ethanol (EtOH), ethyl acetate (EtOAc), hexane (Hex), and methanol (MetOH). Both endophyte species showed varying degrees of inhibition of the bacterial and fungal pathogens according to the solvent used. These results suggest a good relationship between fungal bioactivities and their produced secondary metabolites. Targeting the discovery of potential anti-diabetic, anti-hemolysis, anti-inflammatory, anti-obesity, and cytotoxic activities, endophytic extracts showed promising results. The EtOAc extract of G. candidum displayed IC50 value comparable to the positive control diclofenac sodium in the anti-inflammatory assays. Antioxidant activity was evaluated using α,α-diphenyl-β-picrylhydrazyl (DPPH), β-carotene bleaching, reducing power (RP), and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonique) (ABTS) radical scavenging assays. The findings revealed strong anti-oxidant power with an IC50 of 177.55 µg/mL for G. candidum EtOAc extract using DPPH assay, probably due to high polyphenol and flavonoid content in both fungal extracts. Finally, LC-HRMS (Liquid Chromatography–High Resolution Mass Spectrometry) and GC-MS (Gas Chromatography–Mass Spectrometry) analysis of G. candidum and P. citrinum extracts revealed an impressive arsenal of compounds with previously reported biological activities, partly explaining the obtained results. Finally, LC-HRMS analysis indicated the presence of new fungal metabolites that have never been reported, which represent good candidates to follow for the discovery of new bioactive molecules.

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Section: Discussionmentioning

confidence: 99%

Date Palm Trees Root-Derived Endophytes as Fungal Cell Factories for Diverse Bioactive Metabolites

Mefteh

Daoud

Bouket

et al. 2018

IJMS

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Section: Cell Death Pathwaysmentioning

confidence: 99%

“…Saponins, which are abundant in Ranunculaceae , especially in Clematis , Pulsatilla , Anemone , and Cimicifugeae, usually exert their anti-cancer activities via induction of cell cycle arrest and apoptosis [ 1 , 2 , 6 , 7 ]. The aglycones of Clematis pentacyclic triterpene saponins mainly belong to oleanolic type (A), olean-3β, 28-diol type (B), hederagenin type (C) or hederagenin-11, 13-dien type (D), where types A and C are predominant [ 1 , 7 ]. Many Clematis saponins have cytotoxic activity against human glioblastoma [ 14 ], hepatoma [ 15 ], cervical cancer [ 16 ], leukemia [ 15 , 17 ], gastric cancer [ 15 , 17 ], colon cancer [ 18 ], and prostate cancer [ 19 ].…”

Section: Cell Death Pathwaysmentioning

confidence: 99%

“…The bioactive natural products (plant secondary metabolites) are well known to possess therapeutic value for the prevention and treatment of various types and stages of cancer [ 1 , 2 ]. Ranunculaceae phytometabolites exhibit promising effects against cancer, many of which modulate signaling pathways that are key to cancer initiation and progression, and enhance the anticancer potential of clinical drugs while reducing their toxic side effects.…”

Section: Introductionmentioning

confidence: 99%

“…These genera may contain useful phytometabolites that can be used to combat against cancer. Extracts and/or isolated phytometabolites of at least 17 genera have shown anti-cancer/cytotoxic activities toward various tumor cells [ 1 , 2 , 5 - 7 ]. The distribution of anti-cancer phytometabolites within Ranunculaceae is not random but phylogeny-related [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Anticancer Chemodiversity of Ranunculaceae Medicinal Plants: Molecular Mechanisms and Functions

Hao

Shen³

et al. 2016

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The buttercup family, Ranunculaceae, comprising more than 2,200 species in at least 62 genera, mostly herbs, has long been used in folk medicine and worldwide ethnomedicine since the beginning of human civilization. Various medicinal phytometabolites have been found in Ranunculaceae plants, many of which, such as alkaloids, terpenoids, saponins, and polysaccharides, have shown anti-cancer activities in vitro and in vivo. Most concerns have been raised for two epiphany molecules, the monoterpene thymoquinone and the isoquinoline alkaloid berberine. At least 17 genera have been enriched with anti-cancer phytometabolites. Some Ranunculaceae phytometabolites induce the cell cycle arrest and apoptosis of cancer cells or enhance immune activities, while others inhibit the proliferation, invasion, angiogenesis, and metastasis, or reverse the multi-drug resistance of cancer cells thereby regulating all known hallmarks of cancer. These phytometabolites could exert their anti-cancer activities via multiple signaling pathways. In addition, absorption, distribution, metabolism, and excretion/toxicity properties and structure/activity relationships of some phytometabolites have been revealed assisting in the early drug discovery and development pipelines. However, a comprehensive review of the molecular mechanisms and functions of Ranunculaceae anti-cancer phytometabolites is lacking. Here, we summarize the recent progress of the anti-cancer chemo- and pharmacological diversity of Ranunculaceae medicinal plants, focusing on the emerging molecular machineries and functions of anti-cancer phytometabolites. Gene expression profiling and relevant omics platforms (e.g. genomics, transcriptomics, proteomics, and metabolomics) could reveal differential effects of phytometabolites on the phenotypically heterogeneous cancer cells.

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The role of plant‐derived natural antioxidants in reduction of oxidative stress

et al. 2022

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Free radicals are a group of damaging molecules produced during the normal metabolism of cells in the human body. Exposure to ultraviolet radiation, cigarette smoking, and other environmental pollutants enhances free radicals in the human body. The destructive effects of free radicals may also cause harm to membranes, enzymes, and DNA, leading to several human diseases such as cancer, atherosclerosis, malaria, coronavirus disease (COVID‐19), rheumatoid arthritis, and neurodegenerative illnesses. This process occurs when there is an imbalance between free radicals and antioxidant defenses. Since antioxidants scavenge free radicals and repair damaged cells, increasing the consumption of fruits and vegetables containing high antioxidant values is recommended to slow down oxidative stress in the body. Additionally, natural products demonstrated a wide range of biological impacts such as anti‐inflammatory, anti‐aging, anti‐atherosclerosis, and anti‐cancer properties. Hence, in this review article, our goal is to explore the role of natural therapeutic antioxidant effects to reduce oxidative stress in the diseases.

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Potentilla and Rubus medicinal plants

Cited by 13 publications

References 129 publications

Date Palm Trees Root-Derived Endophytes as Fungal Cell Factories for Diverse Bioactive Metabolites

Date Palm Trees Root-Derived Endophytes as Fungal Cell Factories for Diverse Bioactive Metabolites

Anticancer Chemodiversity of Ranunculaceae Medicinal Plants: Molecular Mechanisms and Functions

The role of plant‐derived natural antioxidants in reduction of oxidative stress

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