The role of plant‐derived natural antioxidants in reduction of oxidative stress

Akbari, Behnaz; Baghaei-Yazdi, Namdar; Bahmaie, Manochehr; Abhari, Fatemeh Mahdavi

doi:10.1002/biof.1831

Cited by 234 publications

(126 citation statements)

References 127 publications

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“…Though, experiments exhibited that TA can activate endogenous antioxidant molecules by boosting Cd removal, inhibiting NADPH oxidase, and modulating their upstream signaling pathways [ 14 , 38 ]. Accordingly, recent investigations found that TA improved antioxidant activity and scavenged free radicals [ 43 , 44 , 45 ]. It is well known that TA has two stabilized aromatic rings, with two hydroxyl groups (–OH) at the meta- and para- positions concerning one other [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Renoprotective and Oxidative Stress-Modulating Effects of Taxifolin against Cadmium-Induced Nephrotoxicity in Mice

Algefare

2022

Life

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Cadmium (Cd) is an inessential trace metal that accumulates in the kidney and may lead to renal toxicity by mediating oxidative stress (OS), inflammatory reactions, and apoptosis. The main objective of this experiment was to inspect the protecting potential of taxifolin (TA) on Cd-induced renal toxicity. Adult male mice were allocated into equal five groups as follows: control, TA-treated (50 mg/kg, oral), CdCl2-treated (4 mg/kg body weight (BW), p.o.), pretreated with TA (25 mg/kg) 1 h before CdCl2 injection (4 mg/kg BW, p.o.), and pretreated with TA (50 mg/kg) 1 h before CdCl2 injection (4 mg/kg BW, p.o.) for 14 days. Cd-intoxicated mice revealed higher serum urea and creatinine levels and notable histopathological alterations in the renal tissues. Malondialdehyde (MDA), nitric oxide (NO), nuclear factor-kappa B (NF-κB) p65, tumor necrosis factor-α (TNF-α), and IL-1β were increased. In contrast, glutathione levels, catalase and superoxide dismutase activities, and IL-10 levels were decreased under Cd-administered effects. Conversely, the TA pre-treatment highly protected tissues from Cd-toxicity, improved renal function, decreased MDA and NO levels, attenuated inflammation, and improved redox status in the renal tissues of Cd-intoxicated mice. The TA pre-treatment of Cd-intoxicated mice showed down-regulation of both Bax and caspase-3 protein and up-regulation of Bcl-2 protein expression in the kidney. Furthermore, TA pre-treatment induced higher upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) expression in kidney cells of Cd-intoxicated mice. Therefore, TA can protect renal tissues against Cd-induced nephrotoxicity via improving redox status, modulating inflammation, diminishing cell apoptosis, and activating the Nrf2/HO-1 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Renoprotective and Oxidative Stress-Modulating Effects of Taxifolin against Cadmium-Induced Nephrotoxicity in Mice

Algefare

2022

Life

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“…The presence of bioactive compounds in medicinal plants causes the numerous biological effects such as antioxidant properties [8,9]. Natural antioxidants derived from medicinal plants are composed of polyphenols (including phenolic acids and flavonoids), carotenoids and vitamins [10]. These natural antioxidants are recognized for their ability to scavenge reactive oxygen species (ROS) [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Dokhani

Nazer²,

skokri³

et al. 2022

Egyptian Journal of Veterinary Sciences

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R ESEARCHERS have shown an increasing attention to the use of medicinal plants because of their beneficial effect on human health. The antioxidant properties of medicinal plants is a strong reason to use them in the food and pharmaceutical industries. Hence, the aim of this study was to evaluate the antioxidant properties of Ziziphus nummularia, Crataegus pontica and Scrophularia striata. Aerial parts of Ziziphus nummularia, Crataegus pontica and Scrophularia striata were dried and ground. Then, plant samples were prepared using homogenizing plant powders in methanol solution. Finally, the total antioxidant capacity of the plants was assessed by ferric iron reducing antioxidant power (FRAP) assay.The results indicated that the total antioxidant capacity was found as 3.16, 2.95 and 1.14 mmol Fe 2+ /L for Ziziphus nummularia, Crataegus pontica and Scrophularia striata, respectively. According to our results, Ziziphus nummularia, Crataegus pontica and Scrophularia striata showed a potent antioxidant activity. It is recommended that utilization of Ziziphus nummularia, Crataegus pontica and Scrophularia striata in food and pharmaceutical industries could possibly possess beneficial health effects.

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“…Numerous studies support the use of antioxidant supplements in lowering oxidative stress and decreasing or preventing the development of disease-related consequences. Furthermore, by scavenging free radicals, antioxidants may aid in preventing diseases such as cancer, cardiovascular disease, Alzheimer's disease, and muscle degeneration (Akbari et al, 2022). The reducing power assay was first performed to explore the Fe 3+ to Fe 2+ transformation in the presence of T. asiatica ethyl acetate extract.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive study of secondary metabolite profile and pharmacological effects of medicinal plant Toddalia asiatica

Lakshmi¹,

Upendra²

2022

j app pharm sci

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Toddalia asiatica (L) Lam is a liana commonly known as an orange climber and is a monotypic genus belonging to the family "Rutaceae." It is one of the widely distributed medicinal plants in the countries, i.e., South Africa, north tropical regions of Africa, Asia, and also in Madagascar. Compounds that exhibit various pharmacological effects, isolated from the various parts of the plant Toddalia asiatica, such as root, root bark, stem, stem bark, flowers, fruits, and leaves have been of prime importance. Traditional medicinal practitioners of the Asian continent have been using this plant since ancient times to treat ailments such as pulmonary diseases and inflammation of joints known as rheumatism. The root and the root bark of the plant are said to be more potent and are used as a remedy for the conditions such as fever, malaria, cholera, diarrhea, neuralgia, sprains, and epilepsy. Fruits of the plant are used as a medication in the conditions, i.e., cough, digestive abnormalities, and viral influenza infection. The vital oil obtained from the root bark of the plant T. asiatica is known to produce strong larvicidal activity against the mosquito species Aedes. The present review emphasizes a variety of pharmacologically active secondary metabolites extracted from the medicinal plant T. asiatica such as coumarins, toddaculin, toddalactone, and their pharmacological effects such as in antiinflammatory, bactericidal, fungicidal, antimalarial, antidiabetic, antiviral, and antitumor activity.

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The role of plant‐derived natural antioxidants in reduction of oxidative stress

Cited by 234 publications

References 127 publications

Renoprotective and Oxidative Stress-Modulating Effects of Taxifolin against Cadmium-Induced Nephrotoxicity in Mice

Renoprotective and Oxidative Stress-Modulating Effects of Taxifolin against Cadmium-Induced Nephrotoxicity in Mice

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

Comprehensive study of secondary metabolite profile and pharmacological effects of medicinal plant Toddalia asiatica

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