Potentiation of Infection by Epinephrine

Splanchnic sympathectomy prevents translocation and spreading of E coli but not S aureus in liver cirrhosis

“…Moreover, chemical SE reduced the splenic bacterial load after intraperitoneal injection of Listeria monocytogenes 47. In addition, treatment with adrenergic agonists increases mortality during Gram-negative bacterial infections 49. Similarly, activation of the sympathetic nervous system by experimental stress led to an increased tissue burden of Gram-negative bacteria 50.…”

Sternal Bone Biopsy in Standing Horses

“…Local anesthetics have been shown to inhibit wound healing in experimental animal models by decreasing the synthesis of collagen and glycosaminoglycans 15 . Also, the addition of epinephrine to lidocaine has been shown to increase wound infection rates in rats 16 . These factors could have contributed to the wound complications encountered in our study.…”

Do Local Anesthetics Have Antibacterial Effect on Staphylococcus aureus Under In Vivo Conditions? An Experimental Study

“…In a wound infection model, Tran and colleagues also demonstrated the potential of wound infection with epinephrine. Reducing the dose of epinephrine also reduced the number of viable bacteria in the wound 9 . On the other hand, epinephrine alone or combined with bicarbonate and lidocaine in tumescent fluid is reported to have some degree of antimicrobial activity 5 .…”

“…Reducing the dose of epinephrine also reduced the number of viable bacteria in the wound. 9 On the other hand, epinephrine alone or combined with bicarbonate and lidocaine in tumescent fluid is reported to have some degree of antimicrobial activity. 5 Of these two conflicting results, the present study showed that epinephrine combined with articaine did not have any significant antimicrobial property.…”