Potentiating photodynamic therapy of ICG-loaded nanoparticles by depleting GSH with PEITC

Hu, Hang; Chen, Jitang; Yang, Hai; Huang, Xian-Ju; Wu, Honglian; Wu, Yuxin; Li, Fenfang; Yi, Yunfei; Xiao, Chen; Li, Yihui; Tang, Yu-Wen; Li, Zifu; Zhang, Bixiang; Yang, Xiangliang

doi:10.1039/c9nr01306g

Cited by 96 publications

(69 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been shown that PEITC has an anticancer mechanism for a variety of cancers. PEITC binds to GSH to form GSH conjugates under the action of GSH S‐transferases, resulting in the depletion of GSH in cells, thereby eradicating cancer cells . Our results indicate that high doses of PEITC (10 µM) can significantly deplete intracellular GSH levels (Figure B).…”

Section: Discussionmentioning

confidence: 73%

Phenylethyl isothiocyanate induces oxidative damage of porcine kidney cells mediated by reactive oxygen species

Zhu

Liu

Yan

et al. 2019

J Biochem & Molecular Tox

View full text Add to dashboard Cite

The aim of this study is to confirm the toxic effect of phenylethyl isothiocyanate (PEITC) on porcine kidney cells (PK-15) and explore the effect of oxidative damage mediated by reactive oxygen species (ROS) induced by PEITC in PK-15 cells. Porcine kidney cell line (PK-15) was treated with PEITC (2, 5, and 10 µM) for 24 hours, and the oxidative damage mediated by PEITC through ROS was investigated. The survival rate of PK-15 cells decreased in a dose-dependent manner after the treatment of PEITC in a dose-dependent manner. A high concentration of PEITC (10 µM) can change cell morphology, increase the content of malondialdehyde, ROS, and lactate dehydrogenase, and decrease the activity of SOD, CAT, GSH-PX, and GSH. PEITC has a toxic effect on PK-15 cells by inducing oxidative stress in PK-15 cells through the generation of ROS. K E Y W O R D S active oxygen, oxidative stress, phenylethyl isothiocyanate, PK-15 cells

show abstract

Section: Discussionmentioning

confidence: 73%

Phenylethyl isothiocyanate induces oxidative damage of porcine kidney cells mediated by reactive oxygen species

Zhu

Liu

Yan

et al. 2019

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…Recently, Yang's group combined ICG-encapsulated nanoparticles with β-Phenylethyl isothiocyanate for potent PDT. [47] After encapsulation, the stability of ICG was enhanced and 1 O 2 was generated efficiently under 808 nm laser irradiation. The nanocomposite could consume intracellular glutathione and consequently boost the PDT efficacy.…”

Section: Nir Light Excited Deep Pdtmentioning

confidence: 99%

“…Besides, ICG is a Food and Drug Administration (FDA) clinically approved NIR PS for PDT. Recently, Yang's group combined ICG‐encapsulated nanoparticles with β‐Phenylethyl isothiocyanate for potent PDT . After encapsulation, the stability of ICG was enhanced and 1 O 2 was generated efficiently under 808 nm laser irradiation.…”

Section: Deep Pdtmentioning

confidence: 99%

Integration of Self‐Luminescence and Oxygen Self‐Supply: A Potential Photodynamic Therapy Strategy for Deep Tumor Treatment

Jiang

Liu

et al. 2020

ChemPlusChem

View full text Add to dashboard Cite

Photodynamic therapy (PDT), as an emerging clinical approach, has been exploited for the treatment of various diseases including cancer for several years. Excitation light and molecular oxygen are the key parameters that restrict the efficacy of PDT due to the restricted penetration depth of light and the hypoxic microenvironment of tumors, which will lead to ineffective therapeutic response. In recent years, a number of studies were focused on tackling these challenges and showed great potential in improving the efficacy of PDT to some degree. Herein, we summarize the advancements in newly developed PDT strategies based on diverse nanocomposites, especially in the aspects of the types of light source and the ways to supply oxygen. Finally, new challenges and possible opportunities for further research are also discussed.

show abstract

“…Super carbonate apatite-ICG NPs improved ICG uptake in tumor cells and its antitumor effect in a colorectal xenograft model, serving as a useful vehicle for ICG-based PDT (Tamai et al, 2018 ). Also, hydroxyethyl starch-oleic acid ICG-NPs exhibited excellent stability and efficient ROS generation and increased cellular uptake and tumor accumulation compared to free ICG (Hu et al, 2019 ).…”

Section: Icg-nps and Cancer: Preclinical Studiesmentioning

confidence: 99%

Indocyanine Green Nanoparticles: Are They Compelling for Cancer Treatment?

et al. 2020

View full text Add to dashboard Cite

Indocyanine green (ICG) is a Food and Drug Administration-approved near-infrared fluorescent dye, employed as an imaging agent for different clinical applications due to its attractive physicochemical properties, high sensitivity, and safety. However, free ICG suffers from some drawbacks, such as relatively short circulation half-life, concentration-dependent aggregation, and rapid clearance from the body, which would confine its feasible application in oncology. Here, we aim to discuss encapsulation of ICG within a nanoparticle formulation as a strategy to overcome some of its current limitations and to enlarge its possible applications in cancer diagnosis and treatment. Our purpose is to provide a short but exhaustive overview of clinical outcomes that these nanocomposites would provide, discussing opportunities, limitations, and possible impacts with regard to the main clinical needs in oncology.

show abstract

Potentiating photodynamic therapy of ICG-loaded nanoparticles by depleting GSH with PEITC

Abstract: In this work, we rationally combined novel ICG@HES-OA NPs with PEITC for potent PDT. The combination of ICG@HES-OA NPs and PEITC results in synergistic PDT efficacy.

Cited by 96 publications

References 51 publications

Phenylethyl isothiocyanate induces oxidative damage of porcine kidney cells mediated by reactive oxygen species

Phenylethyl isothiocyanate induces oxidative damage of porcine kidney cells mediated by reactive oxygen species

Integration of Self‐Luminescence and Oxygen Self‐Supply: A Potential Photodynamic Therapy Strategy for Deep Tumor Treatment

Indocyanine Green Nanoparticles: Are They Compelling for Cancer Treatment?

Contact Info

Product

Resources

About