Potentials of phytosynthesized silver nanoparticles in biomedical fields: a review

Akintelu, Sunday Adewale; Olugbeko, Seyifunmi Charles; Folorunso, Aderonke Similoluwa; Oyebamiji, Abel Kolawole; Folorunso, Femi Adekunle

doi:10.1007/s40089-021-00341-1

Cited by 26 publications

(14 citation statements)

References 156 publications

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“…AgNPs have found widespread application in the design of multi-resistant medications (Ojemaye et al 2021 ) because of their unusual stability, diverse geometries, and ease of release of silver to impede the growth of bacterial cells by creating reactive hydrogen peroxide. Water treatment (Zhao et al 2021 ), agriculture (Khan et al 2021 ), biomedical (Akintelu et al 2021 ), catalysis (Ajitha et al 2021 ), and sensing (Jiang et al 2022 ) are only a few other applications of AgNPs that have been reported. In this study, AgNPs were synthesized from the extract of the brimstone tree ( M. lucida ), a medium-sized tree with crooked, short branches.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis and characterization of silver nanoparticles using Morinda lucida leaf extract and evaluation of its antioxidant and antimicrobial activity

2022

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This study emphasizes the production of eco-friendly silver nanoparticles from a medicinal plant extract of Morinda lucida (M. lucida) and investigated its antioxidant and antimicrobial activity. Phytochemical screening of M. lucida (ML) leave extract was carried out and observed to contain some fundamental phyto-reducing agents such as reducing sugar, proteins, and alkaloids. The green synthesized AgNPs (ML-AgNPs) were characterized by UV–vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), transmission emission microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and Energy dispersive X-ray analysis (EDX). Thermo gravimetric analysis (TGA) was performed on the synthesized ML-capped AgNPs to determine the thermal stability and the formation of the green synthesized AgNPs. The formation of AgNPs was confirmed by the UV–vis absorption spectra, which showed an absorption band at 420 nm. The morphology of ML extract-mediated AgNPs was mostly spherical and rough-edged crystallite nanostructures, with an average particle size of 11 nm. The FTIR analyses revealed distinctive functional groups which were directly involved in the synthesis and stability of AgNPs. The crystallite size was 8.79 nm, with four intense peaks at 2 θ angles of 38°, 44°, 64°, and 77°. At an energy level of 3.4 keV, a significant signal was observed indicating the production of thermally stable and pure crystallite AgNPs. The antioxidant property of green synthesized ML-AgNPs was determined to be 40% higher than that of crude M. lucida leaf extract. The ability of green synthesized ML-AgNPs to scavenge free radicals also increased in the order of OH − < NO < H 2 O 2 . The ML-AgNPs have strong activities with a maximum against P. vulgaris and a minimum with E. faecalis.

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Section: Introductionmentioning

confidence: 99%

Green synthesis and characterization of silver nanoparticles using Morinda lucida leaf extract and evaluation of its antioxidant and antimicrobial activity

2022

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“…Consequently, AgNPs now have important applications in therapeutics, diagnostics and catalysis, as well as in analytical techniques as signal enhancer in surface-enhanced Raman spectroscopy (SERS). [11][12][13] In recent years, there has been an upsurge of interest in the potential use of AgNPs to combat antibiotic resistance, which is oen caused by the inappropriate/overuse use of antibiotics. 14,15 The synergistic effect exerted by AgNPs when coupled with antibacterial drug groups, such as b-lactams, 16 aminoglycosides, glycopeptides and sulfonamides, 17 enhances antimicrobial activity against multidrug-resistant bacteria.…”

Section: Introductionmentioning

confidence: 99%

Effect of the physicochemical changes in the antimicrobial durability of green synthesized silver nanoparticles during their long-term storage

et al. 2022

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“…Silver nanoparticle (AgNP) is one of the emerging and fastest growing materials in the field of nanotechnology [1][2][3] and Biomedicine [4][5][6][7][8] that benefited from the advancements in the studies of nanoparticles [9][10][11][12][13][14] and applications such as in catalysis [15][16][17][18][19][20][21][22][23][24][25][26][27][28] . The rapid growth of Agbased nanomaterials is attributed to silver's antimicrobial properties [29][30][31][32][33][34][35] , good optical, conductive, and other outstanding properties [36][37][38][39] .…”

Section: Introductionmentioning

confidence: 99%

Osmotic pressure induced toxicity by aggregation of citrate-coated silver nanoparticles inside HepG2 cells

Ubaldo

Abshiro

Cavender

et al. 2022

Preprint

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The effects of 10nm citrate-coated silver nanoparticles (AgNPs) to hepatocellular carcinoma (HepG2) cells were investigated to elucidate toxicity mechanisms. Cell viability, oxidative stress, protein expression, and cell morphology were assessed to determine the toxicity of AgNPs at various dose levels. 10nm citrate-coated AgNPs were found to be toxic to HepG2 cells at a dose of > 1.0 ppm and their LD50 was determined to be 3.0 ppm. Oxidative stress levels in the cells were found to increase with the dose of AgNPs and HepG2 cells can withstand high level of reactive oxygen species before cell death. The expressions of heat shock proteins and tubulin proteins were most significantly affected by the presence of AgNPs of 5.0 ppm. The AgNPs were observed to penetrate the cells treated with a dose of 5.0 ppm by transmission electron microscopy. Furthermore, the agglomeration of AgNPs in HepG2 cells was found and generated osmotic pressure that is likely another pathway to be responsible for the toxicity of AgNPs.

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Potentials of phytosynthesized silver nanoparticles in biomedical fields: a review

Cited by 26 publications

References 156 publications

Green synthesis and characterization of silver nanoparticles using Morinda lucida leaf extract and evaluation of its antioxidant and antimicrobial activity

Green synthesis and characterization of silver nanoparticles using Morinda lucida leaf extract and evaluation of its antioxidant and antimicrobial activity

Effect of the physicochemical changes in the antimicrobial durability of green synthesized silver nanoparticles during their long-term storage

Osmotic pressure induced toxicity by aggregation of citrate-coated silver nanoparticles inside HepG2 cells

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