Abstract:The effects of 10nm citrate-coated silver nanoparticles (AgNPs) to hepatocellular carcinoma (HepG2) cells were investigated to elucidate toxicity mechanisms. Cell viability, oxidative stress, protein expression, and cell morphology were assessed to determine the toxicity of AgNPs at various dose levels. 10nm citrate-coated AgNPs were found to be toxic to HepG2 cells at a dose of > 1.0 ppm and their LD50 was determined to be 3.0 ppm. Oxidative stress levels in the cells were found to increase with the dose o… Show more
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