Potentially inappropriate medications with polypharmacy increase the risk of falls in older <scp>J</scp>apanese patients: 1‐year prospective cohort study

Masumoto, Shoichi; Maeno, Takami; Ichinohe, Yumiko; Maeno, Tetsuhiro

doi:10.1111/ggi.13307

Cited by 44 publications

(37 citation statements)

References 28 publications

(57 reference statements)

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“…Our previous study 16 and another Japanese study using STOPP criteria version 2 had also reported that these medications were frequently detected as PIM. 17 In contrast, several medications were detected as PIM by using STOPP-J, but were not always detected by using STOPP criteria version 2 in the present study. Among these medications, H2 receptor antagonists, laxatives magnesium oxide and α-glucosidase inhibitors were not included in STOPP criteria version 2; thus, the detection of these PIM by STOPP-J was considered meaningful.…”

Section: Discussioncontrasting

confidence: 82%

“…18 STOPP criteria version 2 has been reported to detect more PIM than Beers Criteria 2012, 19,20 the European Union (7)-PIM list and the comprehensive protocol. 21 The proportion of patients with PIM based on STOPP-J in the present study was higher than that based on STOPP criteria version 2 and the results of the other study using STOPP criteria version 2 16,17 and Beers Criteria 2012. 18 These results suggested the efficacy of STOPP-J for detection of PIM in Japanese older adults.…”

Section: Discussioncontrasting

confidence: 67%

“…In the present study, PIM related to benzodiazepines, NSAIDs and sulphonylureas were frequently detected in STOPP‐J and STOPP criteria version 2. Our previous study and another Japanese study using STOPP criteria version 2 had also reported that these medications were frequently detected as PIM . In contrast, several medications were detected as PIM by using STOPP‐J, but were not always detected by using STOPP criteria version 2 in the present study.…”

Section: Discussioncontrasting

confidence: 49%

“…We had previously reported that 42.1% of study patients were prescribed at least one PIM based on STOPP criteria version 2 in the observational study . In addition, a prospective observational study carried out at a Japanese primary care clinic reported that the prevalence of PIM based on STOPP criteria version 2 was 32.3% of study patients . Meanwhile, a retrospective cohort study carried out in long‐term care facilities reported that patients with PIM based on Beers Criteria 2012 comprised 37.5% of study patients .…”

Section: Discussionmentioning

confidence: 98%

“…16 In addition, a prospective observational study carried out at a Japanese primary care clinic reported that the prevalence of PIM based on STOPP criteria version 2 was 32.3% of study patients. 17 Meanwhile, a retrospective cohort study carried out in long-term care facilities reported that patients with PIM based on Beers Criteria 2012 comprised 37.5% of study patients. 18 STOPP criteria version 2 has been reported to detect more PIM than Beers Criteria 2012, 19,20 the European Union (7)-PIM list and the comprehensive protocol.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of pharmacists' assessment and intervention based on Screening Tool for Older Persons' Appropriate Prescriptions for Japanese compared with Screening Tool for Older Persons' Appropriate Prescriptions for Japanese criteria version 2 in older patients with cardiovascular disease

Kondo

Ogura

Kukita

et al. 2019

Geriatrics Gerontology Int

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Aim This study aimed to evaluate the efficacy of pharmacists' assessment and intervention using the Screening Tool for Older Persons' Appropriate Prescriptions for Japanese (STOPP‐J) to detect and correct potentially inappropriate medications (PIM) compared with the Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) criteria version 2. Methods A prospective observational study was carried out at a medical unit of Cardiovascular Surgery and Cardiovascular Internal Medicine in a Japanese university hospital involving new inpatients aged ≥65 years prescribed one or more daily medication. Pharmacists detected PIM based on STOPP‐J and STOPP criteria version 2, and corrected them with physicians. The number of patients with PIM, the content and changes in PIM were compared between both criteria. Results Overall, 230 patients were included (mean age 75.4 years, 162 men, mean number of medications 8.3). STOPP‐J detected significantly more patients with PIM than STOPP criteria version 2 (122 [53%] vs 75 [33%], P < 0.001). The number of PIM based on STOPP‐J was 232, the physicians were recommended to change 61 (26%) and 50 (22%) were changed. Meanwhile, the number of PIM based on STOPP criteria version 2 was 133, the physicians were recommended to change 61 (46%) and 54 (41%) were changed. Several medications detected as PIM using STOPP‐J were not detected using STOPP criteria version 2. Conclusions STOPP‐J detected significantly more patients with PIM than STOPP criteria version 2, and pharmacists' assessment and intervention based on STOPP‐J were suggested to be effective for detecting and correcting PIM. Geriatr Gerontol Int 2019; 19: 1101–1107.

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Section: Discussioncontrasting

confidence: 82%

Section: Discussioncontrasting

confidence: 67%

Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Efficacy of pharmacists' assessment and intervention based on Screening Tool for Older Persons' Appropriate Prescriptions for Japanese compared with Screening Tool for Older Persons' Appropriate Prescriptions for Japanese criteria version 2 in older patients with cardiovascular disease

Kondo

Ogura

Kukita

et al. 2019

Geriatrics Gerontology Int

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Potentially inappropriate medications among elderly patients in community healthcare institutions in Beijing, China

Wushouer

Nie

et al. 2020

Pharmacoepidemiology and Drug

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PurposeTo evaluate potentially inappropriate medications (PIMs) prevalence and predictors in community healthcare institutions (CHIs) for the elderly.MethodsWe conducted a retrospective observational study, deriving data of patients aged ≥60 from 66 CHIs in Beijing, 2014‐2018. The system of Criteria of PIM for Older Adults in China was applied to identify PIMs. The primary outcome was the prevalence of visits with at least one PIM; secondary outcomes were the frequency and rate per thousand visits of specific PIMs. We used descriptive analysis and generalized linear models to analyzed PIMs and the predictors, and marginal effects methods were applied to estimate the mean adjusted PIMs prevalence.ResultsOverall, 4 528 884 elderly patient visits from 2014 to 2018 were eligible for inclusion. A total of 719 757 PIMs were detected, with 14.1% of the visits contained at least one PIM. PIM prevalence was significantly correlated with age, number of prescribed medications and number of diagnoses. Overall, 6.0 per thousand elderly patients in CHIs were exposed to at least one high‐risk PIM, while 117.5 per thousand were exposed to at least one low‐risk PIM. In 2018, 20% of GPs were responsible for more than half of overall PIM visits.ConclusionPrescribing of PIMs for older adults is common in CHIs in China, especially for patients who are aged, having multiple medications and diagnostic diseases. Strategies should be developed to enhance prescribing quality for geriatric patients, with special targeting of doctors responsible for a high number of PIMs.

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Potentially inappropriate prescribing in a falls clinic using the STOPP and START criteria

et al. 2021

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Potentially inappropriate medications with polypharmacy increase the risk of falls in older Japanese patients: 1‐year prospective cohort study

Abstract: The combination of PIMs and polypharmacy might increase the risk of falls, therefore clinicians need to pay attention to both PIMs and polypharmacy. Geriatr Gerontol Int 2018; 18: 1064-1070.

Cited by 44 publications

References 28 publications

Efficacy of pharmacists' assessment and intervention based on Screening Tool for Older Persons' Appropriate Prescriptions for Japanese compared with Screening Tool for Older Persons' Appropriate Prescriptions for Japanese criteria version 2 in older patients with cardiovascular disease

Efficacy of pharmacists' assessment and intervention based on Screening Tool for Older Persons' Appropriate Prescriptions for Japanese compared with Screening Tool for Older Persons' Appropriate Prescriptions for Japanese criteria version 2 in older patients with cardiovascular disease

Potentially inappropriate medications among elderly patients in community healthcare institutions in Beijing, China

Potentially inappropriate prescribing in a falls clinic using the STOPP and START criteria

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