Efficacy of pharmacists' assessment and intervention based on Screening Tool for Older Persons' Appropriate Prescriptions for Japanese compared with Screening Tool for Older Persons' Appropriate Prescriptions for Japanese criteria version 2 in older patients with cardiovascular disease

Abstract

Aim This study aimed to evaluate the efficacy of pharmacists' assessment and intervention using the Screening Tool for Older Persons' Appropriate Prescriptions for Japanese (STOPP‐J) to detect and correct potentially inappropriate medications (PIM) compared with the Screening Tool of Older Persons' Potentially Inappropriate Prescriptions (STOPP) criteria version 2. Methods A prospective observational study was carried out at a medical unit of Cardiovascular Surgery and Cardiovascular Internal Medicine in a Japanese university hospital involving new inpatients aged ≥65 years prescribed one or more daily medication. Pharmacists detected PIM based on STOPP‐J and STOPP criteria version 2, and corrected them with physicians. The number of patients with PIM, the content and changes in PIM were compared between both criteria. Results Overall, 230 patients were included (mean age 75.4 years, 162 men, mean number of medications 8.3). STOPP‐J detected significantly more patients with PIM than STOPP criteria version 2 (122 [53%] vs 75 [33%], P < 0.001). The number of PIM based on STOPP‐J was 232, the physicians were recommended to change 61 (26%) and 50 (22%) were changed. Meanwhile, the number of PIM based on STOPP criteria version 2 was 133, the physicians were recommended to change 61 (46%) and 54 (41%) were changed. Several medications detected as PIM using STOPP‐J were not detected using STOPP criteria version 2. Conclusions STOPP‐J detected significantly more patients with PIM than STOPP criteria version 2, and pharmacists' assessment and intervention based on STOPP‐J were suggested to be effective for detecting and correcting PIM. Geriatr Gerontol Int 2019; 19: 1101–1107.

Association of Self-Reported Medication Adherence with Potentially Inappropriate Medications in Elderly Patients: A Cross-Sectional Pilot Study

“…Furthermore, our study demonstrated that there is also a significant association between PP and PIM use, which is supported by previous reports [8,[20][21][22][23][24][25][26][27]. The frequency of elderly PIM(+) patients in Japan varies from 22.9% to 67.3% [8,22,23,27,31,35,68,71,72] because of different study populations and settings, different definitions of PIMs, or different timings of the investigation.…”

“…The list of target drugs, target patient populations, and recommendations developed by the JGS, available on the JGS web page for the STOPP-J in Japanese [55], was used for PIM screening [31]. The list used in this study was shown in Table S1.…”

“…Potentially inappropriate medications (PIMs), defined as medications with more harmful than beneficial effects on elderly patients [19], are closely related to PP [8,[20][21][22][23][24][25][26][27] and are a relevant public health concern for elderly patients [28,29]. In 2015, the Japan Geriatric Society (JGS) updated the "Guidelines for Medical Treatment and its Safety in the Elderly" and proposed medication lists regarding PIMs, "Screening Tool for Older Persons' Appropriate Prescriptions for Japanese" (STOPP-J), to contribute to improving prescription quality [30,31]. PIMs, similar to PP, are associated with an increased risk of ADEs [27,[32][33][34][35], which increases with age [23].…”

Potentially Inappropriate Medication and Associated Factors Among Older Patients with Chronic Coronary Syndrome at Hospital Discharge in Beijing, China

“…The result was slightly lower than previous results. 11,13,35 This discrepancy may be due to different settings. For instance, those with acute coronary syndrome and cardiovascular diseases without coronary lesions were excluded.…”

Potentially inappropriate medication discontinued or changed based on pharmacists’ recommendations in older end-stage cancer patients receiving palliative care: a cross-sectional study

“…Recently, potentially inappropriate medications (PIMs) in older cancer patients have become a growing serious clinical problem, especially after Chen et al and Mohamed et al reported that reducing PIMs can reduce adverse events and prevent premature death in older cancer patients (1,2). To reduce PIMs, it has been reported that not only physicians, who prescribe, but also pharmacists, who detect PIMs and recommend to physicians to discontinue or change the prescription, are important (3)(4)(5). Furthermore, many researchers have reported that pharmacists can reduce PIMs for older cancer patients as well, highlighting the role of these professionals in the field of cancer medicine (6)(7)(8)(9).…”