Potentially Inappropriate Medications, Drug–Drug Interactions, and Anticholinergic Burden in Elderly Hospitalized Patients: Does an Association Exist with Post-Discharge Health Outcomes?

Vincentis, Antonio De; Gallo, Paolo; Finamore, Panaiotis; Pedone, Claudio; Costanzo, Luisa Di; Pasina, Luca; Cortesi, Laura; Nobili, Alessandro; Mannucci, Pier Mannuccio; Incalzi, Raffaele Antonelli

doi:10.1007/s40266-020-00767-w

Cited by 33 publications

(53 citation statements)

References 43 publications

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“…Concerning polypharmacy, it is inherent to the aging process and is connected to the health needs of this population, which often has more than one morbidity, including diseases related to the central nervous system and inappropriate lifestyle habits, such as physical inactivity and inadequate diet. The sum of these factors provides multiple medication prescriptions, which may be related to PIM, mainly in PHC (7,(22)(23)26,(28)(29) .…”

Section: Discussionmentioning

confidence: 99%

Factors associated with the use of potentially inappropriate medications by elderly people with hypertension

et al. 2020

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Objective: to analyze factors associated with the use of potentially inappropriate medications by elderly people with hypertension. Method: a cross-sectional study, conducted in the first semester of 2016, with elderly people undergoing treatment for hypertension, living in the city of Maringá. Interviews, medical records analysis, and measurement of clinical and anthropometric parameters of the participants were carried out. Inferential analysis was used. Results: a total of 260 elderly people who used potentially inappropriate medications participated in the study. The high use of these medications was associated with clinical and anthropometric conditions, such as obesity (p=0.022), smoking (p=0.004), polypharmacy (p=0.034) and the health services provided, such as organizationally accessible treatment (p=0.027) and consultation time (p=0.007), predisposing to low adherence to routine consultations (p=0.003). Conclusion: it was shown that the factors associated with the use of potentially inappropriate medications were associated with anthropometric, clinical, and organizational variables, intrinsic to the family health strategy.

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Section: Discussionmentioning

confidence: 99%

Factors associated with the use of potentially inappropriate medications by elderly people with hypertension

et al. 2020

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“…The Beers Criteria is used to classify PIM; the list is constantly updated, with new insights into medications that can interfere with and cause divergences to their expected outcomes. To date, two studies have relied on the Beers 2019 criteria [ 22 , 23 ]. One study involved a three-month follow-up and identified that PIMs cause mortality in hospitalized elderly [ 22 ] and the other study investigated PIM use in a community-dwelling population [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Potentially inappropriate medications for the elderly: Incidence and impact on mortality in a cohort ten-year follow-up

et al. 2020

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Introduction Pharmacological therapy plays an important role in disease control in the elderly; unfortunately, this comes with a high prevalence in the use of medications classified as potentially inappropriate. Objective To analyze the incidence, risk factors, and survival of elderly people using potentially inappropriate medications (PIM). Method A ten-year follow-up assessment of elderly participants residing in a capital of Central Brazil was conducted. The initial assessment (baseline) included 418 elderly people. Data were collected through home interviews guided by a questionnaire covering socioeconomic, demographic, living conditions, and health variables. The medication information obtained comprised active ingredient, dosage, route, and regimen for the medications. The PIMs were classified according to 2019 Beers Criteria. The analyses were performed using STATA 15.0. For survival analysis, a Cox Regression was performed with the respective Kaplan Meier curve. Results The incidence of PIM was 44.1 cases (95% CI: 35.2–54.7) per 1,000 people a year. The most used PIMs were nifedipine, glibenclamide, and sodium diclofenac. The risk factors were polypharmacy (aRR: 3.00; 95% CI: 1.31–6.88) and diabetes mellitus (aRR: 1.57; 95% CI: 1.03–2.39). We identified no statistically significant association between survival and the use of PIM. Conclusion The study highlights the high consumption of PIM among the elderly causing polypharmacy risks. Health professionals working in drug treatment need to be alert to polypharmacy risks to ensure the rational use of medications to prevent adverse reactions and other health problems.

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“…vant DDIs can be associated with increasing the risk of poor health related QoL in elderly with T2D. To the best of our knowledge, these results have not previously been reported.Previous study by Antonio De Vincentis and colleagues found that only polypharmacy which considered as simple measure surpass PIM and DDI indicators of quality of therapy as it correlate of primary clinical outcomes, that are mortality and rehospitalization44 …”

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confidence: 99%

Polypharmacy, potentially serious clinically relevant drug‐drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life

AL-Musawe

Torre

Guerreiro³

et al. 2020

Pharmacology Res & Perspec

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Potentially Inappropriate Medications, Drug–Drug Interactions, and Anticholinergic Burden in Elderly Hospitalized Patients: Does an Association Exist with Post-Discharge Health Outcomes?

Cited by 33 publications

References 43 publications

Factors associated with the use of potentially inappropriate medications by elderly people with hypertension

Factors associated with the use of potentially inappropriate medications by elderly people with hypertension

Potentially inappropriate medications for the elderly: Incidence and impact on mortality in a cohort ten-year follow-up

Polypharmacy, potentially serious clinically relevant drug‐drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life

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