Potentially Critical Roles ofNDUFB5,TIMMDC1,and VDAC3in the Progression of Septic Cardiomyopathy Through Integrated Bioinformatics Analysis

Kai, Kang; Li, Jingtian; Li, Ruidong; Xu, Xiufeng; Liu, Jianli; Qin, Linling; Huang, Tao; Wu, Jinhua; Jiao, Min; Wei, Miaomiao; Wang, Hongjie; Wang, Tao; Zhang, Quan

doi:10.1089/dna.2019.4859

Cited by 12 publications

(11 citation statements)

References 45 publications

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“…Pathogenic mutations in MRPL3 were responsible for the clinical phenotype of combined oxidative phosphorylation deficiency-9 (COXPD9), in which severe hypertrophic cardiomyopathy is a central presentation [4]. mrpl16 has been shown to be significantly associated with septic cardiomyopathy [17]. The genetic variation in MRPL37 was linked to an increased risk of venous thromboembolism recurrence [37].…”

Section: Mrps and Heart Diseasesmentioning

confidence: 99%

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Huang

Zhang

2020

IJMS

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Mammalian mitochondrial ribosomes translate 13 proteins encoded by mitochondrial genes, all of which play roles in the mitochondrial respiratory chain. After a long period of reconstruction, mitochondrial ribosomes are the most protein-rich ribosomes. Mitochondrial ribosomal proteins (MRPs) are encoded by nuclear genes, synthesized in the cytoplasm and then, transported to the mitochondria to be assembled into mitochondrial ribosomes. MRPs not only play a role in mitochondrial oxidative phosphorylation (OXPHOS). Moreover, they participate in the regulation of cell state as apoptosis inducing factors. Abnormal expressions of MRPs will lead to mitochondrial metabolism disorder, cell dysfunction, etc. Many researches have demonstrated the abnormal expression of MRPs in various tumors. This paper reviews the basic structure of mitochondrial ribosome, focuses on the structure and function of MRPs, and their relationships with cell apoptosis and diseases. It provides a reference for the study of the function of MRPs and the disease diagnosis and treatment.

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Section: Mrps and Heart Diseasesmentioning

confidence: 99%

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Huang

Zhang

2020

IJMS

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“…As we pointed out in Table 4 , two previous papers reported that identification of hub genes in human septic cardiomyopathy using bioinformatic analysis ( Chen et al., 2020 ; Kang et al., 2020 ). Here, we presented that several findings in our study are significantly novel in comparing to what these two published papers.…”

Section: Discussionmentioning

confidence: 99%

Identification and Validation of Immune-Related Biomarker Gene and Construction of ceRNA Networks in Septic Cardiomyopathy

et al. 2022

Front. Cell. Infect. Microbiol.

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Septic cardiomyopathy (SCM) is a cardiac dysfunction caused by severe sepsis, which greatly increases the risk of heart failure and death, and its molecular mechanism is unclear. The immune response has been reported to be an important process in septic cardiomyopathy and is present in the cardiac tissue of patients with sepsis, suggesting that the immune response may be an underlying mechanism of myocardial injury in SCM. Therefore, we explored the role of immune-related genes (IRGs) in SCM and aimed to identify pivotal immune-related targets with the aim of identifying key immune-related targets in SCM and potential therapeutic mechanisms involved in the pathological process of SCM. To explore the regulatory mechanisms of immune responses in SCM, we identified differentially expressed genes (DEGs) shared in the SCM datasets GSE179554 and GSE40180 by bioinformatics analysis and then obtained hub genes from the DEGs. Then, we obtained the immune-related hub genes (IRHGs) by intersecting the hub genes with IRGs and performed quantitative reverse transcription polymerase chain reaction to confirm the abnormal expression of IRHGs. Finally, we further constructed an immune-related lncRNA–miRNA–IRHG ceRNA regulatory network. In this study, we identified an IRHG that may be involved in the pathogenesis of SCM, which helps us to further elucidate the role of immune response in SCM and gain insights into the molecular mechanisms and potential therapeutic targets of SCM.

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“…Thus, WGCNA has been widely used in the study of various diseases, including CVDs (Chen et al, 2016;Wang Y. et al, 2019). Kang et al (2020) performed the WGCNA in GSE79962 and revealed the potential critical roles of NDUFB5, TIMMDC1, and VDAC3 in the septic cardiomyopathy progression. Using microarray data of coronary artery diseases (CADs; GSE23561), studies detected a co-expression module associated with hypertrophic cardiomyopathy pathway in CAD and found that G6PD and S100A7 were the potential targets (Liu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Critical Roles of ELVOL4 and IL-33 in the Progression of Obesity-Related Cardiomyopathy via Integrated Bioinformatics Analysis

Tao

Wang

et al. 2020

Front. Physiol.

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The molecular mechanisms underlying obesity-related cardiomyopathy (ORCM) progression involve multiple signaling pathways, and the pharmacological treatment for ORCM is still limited. Thus, it is necessary to explore new targets and develop novel therapies. Microarray analysis for gene expression profiles using different bioinformatics tools has been an effective strategy for identifying novel targets for various diseases. In this study, we aimed to explore the potential genes related to ORCM using the integrated bioinformatics analysis. The GSE18897 (whole blood expression profiling of obese diet-sensitive, obese diet-resistant, and lean human subjects) and GSE47022 (regular weight C57BL/6 and diet-induced obese C57BL/6 mice) were used for bioinformatics analysis. Weighted gene co-expression network analysis (WGCNA) of GSE18897 was employed to investigate gene modules that were strongly correlated with clinical phenotypes. Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the co-expression genes. The expression levels of the hub genes were validated in the clinical samples. Yellow co-expression module of WGCNA in GSE18897 was found to be significantly related to the caloric restriction treatment. In addition, GO functional enrichment analysis and KEGG pathway analysis were performed on the coexpression genes in yellow co-expression module, which showed an association with oxygen transport and the porphyrins pathway. Overlap analysis of yellow co-expression module genes from GSE18897 andGSE47022 revealed six upregulated genes, and further experimental validation results showed that elongation of very-long-chain fatty acids protein 4 (ELOVL4), matrix metalloproteinase-8 (MMP-8), and interleukin-33 (IL-33) were upregulated in the peripheral blood from patients with ORCM compared to that in the controls. The bioinformatics analysis revealed that ELOVL4 expression levels are positively correlated with that of IL-33. Collectively, using WGCNA in combination with integrated bioinformatics analysis, the hub genes of ELVOL4 and IL-33 might serve as potential biomarkers for diagnosis and/or therapeutic targets for ORCM. The detailed roles of ELVOL4 and IL-33 in the pathophysiology of ORCM still require further investigation.

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Potentially Critical Roles ofNDUFB5,TIMMDC1,and VDAC3in the Progression of Septic Cardiomyopathy Through Integrated Bioinformatics Analysis

Cited by 12 publications

References 45 publications

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Identification and Validation of Immune-Related Biomarker Gene and Construction of ceRNA Networks in Septic Cardiomyopathy

Critical Roles of ELVOL4 and IL-33 in the Progression of Obesity-Related Cardiomyopathy via Integrated Bioinformatics Analysis

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